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How does cholesterol in the brain regulate ion channels and change their functions?

 Last Update: 2021-09-03
 Source: Internet
 Author: User

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Through a structural and functional approach, researchers from the Icahn School of Medicine at Mount Sinai and Stanford University Medical Center determined the physical binding site of cholesterol in the g-protein-gated internal rectifier potassium (GIRK) channel of the brain.

The team solved the three-dimensional structure of the GIRK channel and revealed the physical location where cholesterol directly interacts with the channel

Research Interests: Our brain contains a lot of cholesterol.

This is a collaborative study between the Skiniotis Laboratory at Stanford University School of Medicine and the Slesinger Laboratory at Mount Sinai

Research content: The research team demonstrated the structure of GIRK2 channels in the presence and absence of cholesterol derivatives cholesterol hemisuccinate (CHS) and membrane phospholipids (PIP2)

In order to better understand the structural basis of GIRK channel cholesterol regulation, they used cryo-electron microscopy to observe GIRK2 under different conditions

Analysis conclusion:

Elevated cholesterol levels in certain neurodegenerative diseases can affect the function of ion channels

Thesis title: Structural insights into GIRK2 channel modulation by cholesterol and PIP ₂

Dr.

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