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Bristol-Myers Squibb's CAR-T therapy for second-line treatment of large B-cell lymphoma gets priority review
Time of Update: 2022-05-01
S. Food and Drug Administration (FDA) has granted Priority Review status to the supplemental Biologics License Application (sBLA) for Breyanzi (lisocabtagene maraleucel), a CAR-T cell therapy targeting CD19, to expand Its current indication is for the treatment of adult patients with relapsed/refractory large B-cell lymphoma (LBCL) after failure of first-line therapy .
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Treat Biliary Cancer!
Time of Update: 2022-05-01
/Patheon Manufacturing Services LLC injection ZW25 is planned to be included in the breakthrough therapy category .
ZW25 for injection as a single agent for the treatment of HER2-positive locally advanced unresectable or metastatic biliary tract cancer (BTC) that has failed previous systemic chemotherapy .
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AIDS "cured" after stem cell transplantation, the third case in the world may appear!
Time of Update: 2022-05-01
As a last resort for a cure for the blood tumor, she received a stem cell transplant -- which carries a key mutation in the CCR5 gene that makes the body immune to HIV .
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Denali macromolecule delivery technology that breaks through the blood-brain barrier is expected to advance to phase 2/3 clinical trials
Time of Update: 2022-05-01
Long-term data from 20 patients showed that after up to 1 year of administration, the drug could continue to reduce the level of disease-related biomarkers in the patient's brain, and initially improve clinical symptoms, with a good safety profile .
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Scientists reveal the effect of tumor exosomes on NK cells in tumor immunotherapy
Time of Update: 2022-05-01
1186/s12943-021-01492-7Recently, researchers from the Faculty of Medicine of the Medical University of Isfahan published a review article entitled "Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy" in the journal Molecular Cancer, on the role of TDEs in tumor induction.
Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy.
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Zuranolone Phase III Clinical Success for Major Depression
Time of Update: 2022-05-01
A major problem in the development of antidepressants is the large placebo effect, and the rapid improvement in scores of both groups of patients can be seen from the time curve, which makes it very difficult for the drug to show outstanding efficacy .
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Positive Phase 3 clinical results of BMS potential blockbuster therapy for cardiomyopathy patients
Time of Update: 2022-05-01
References:[1] Bristol Myers Squibb Announces Positive Topline Results from Phase 3 VALOR-HCM Trial, Evaluating Mavacamten in Patients with Obstructive Hypertrophic Cardiomyopathy Who are Eligible for Septal Reduction Therapy.
com /news/corporate-financial/2022/Bristol-Myers-Squibb-Announces-Positive-Topline-Results-from-Phase-3-VALOR-HCM-Trial-Evaluating-Mavacamten-in-Patients-with-Obstructive-Hypertrophic-Cardiomyopathy -Who-are-Eligible-for-Septal-Reduction-Therapy/default.
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How much does exercising consistently help the brain?
Time of Update: 2022-05-01
Effects of 5 Years Aerobic Exercise on Cognition in Older Adults: The Generation 100 Study: A Randomized Controlled Trial.
5 Years of Exercise Intervention Did Not Benefit Cognition Compared to the Physical Activity Guidelines in Older Adults, but Higher Cardiorespiratory Fitness Did.
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Encapsulating innovative therapies such as trispecific cytokine inhibitors and cutting-edge immune-inflammatory diseases
Time of Update: 2022-05-01
Bioniz's lead product candidates are multispecific inhibitors that simultaneously target multiple clinically validated disease-driving cytokines, including potential "first-in-class" therapies BNZ-1 and BNZ-2 in clinical development, aimed at Addressing unmet needs in a range of immuno-inflammatory indications .
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Deadly viruses hide deep in the brain!
Time of Update: 2022-05-01
Retrieved Feb 15th, 2022 from https:// Jun Liu et al, Ebola Virus Persistence and Disease Recrudescence in the Brains of Antibody-Treated Nonhuman Primate Survivors, Science Translational Medicine (2022).
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How old can you play with your phone and watch TV?
Time of Update: 2022-05-01
A recent study published in JAMA Pediatrics further found that in boys, prolonged exposure to electronic screens at age 1 was significantly associated with a diagnosis of autism spectrum disorder at age 3 .
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FDA Breakthrough Therapy Designation for Novel RSV Vaccine Prompts Broad Immune Response
Time of Update: 2022-05-01
S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation to the vaccine candidate MVA-BN RSV for active immunization of adults 60 years of age or older to prevent lower respiratory tract infections caused by respiratory syncytial virus (RSV).
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Keytruda combination therapy to prevent recurrence of 'most toxic' breast cancer dramatically improves survival
Time of Update: 2022-05-01
The findings suggest that adding pembrolizumab (Keytruda) to standard preoperative (neoadjuvant) chemotherapy in triple-negative breast cancer can prevent recurrence and improve long-term survival .
The short-term goal of neoadjuvant therapy is to achieve pathological complete response, as pathological complete response is associated with prolonged event-free and overall survival in patients with triple-negative breast cancer .
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mRNA COVID-19 vaccine shows good stability and immunogenicity in preclinical studies
Time of Update: 2022-05-01
On February 12, Ruike Biotech announced the preclinical data of its subsidiary Wuhan Ruikeji Biotechnology Co. , Ltd. (“Rikeji Bio”) freeze-dried dosage form of mRNA new coronary pneumonia vaccine .
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Google's AlphaFold deciphers "God's code" to solve problems that have plagued mankind for 50 years
Time of Update: 2022-05-01
Predicting how proteins will fold and what their stable conformations will be through the calculations of AlphaFold2 can open up a whole new field of biological research .
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ASK-related neutralizing antibody cocktail blocks SARS-CoV-2 infection in human lung organoids
Time of Update: 2022-05-01
This study identifies a set of receptor-like host factors with distinct S-binding modes, signaling properties, and tissue distribution, and demonstrates that ASGR1 and KREMEN1 are alternative functional receptors that play important roles in ACE2-independent viral entry, Provides insight into key virus-host interactions of SARS-CoV-2, as well as useful resources and potential drug targets for further research on COVID-19 .
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Positive results from pivotal clinical trials of Biohaven and Pfizer's oral CGRP receptor antagonists
Time of Update: 2022-05-01
References:[1] Biohaven and Pfizer Announce Positive Topline Results of Pivotal Trial of Rimegepant for the Acute Treatment of Migraine in China and South Korea.
Retrieved February 14, 2022, from https:// and-pfizer-announce-positive-topline-results-of-pivotal-trial-of-rimegepant-for-the-acute-treatment-of-migraine-in-china-and-south-korea-301481322.
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A major breakthrough in acoustic genetics: the first use of sound to activate mammalian cells
Time of Update: 2022-05-01
In a paper published in Nature Communications, the research team successfully used ultrasound pulses to activate human cells in vitro and gene-edited neurons in living mice .
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150,000 new crown infected people show increased risk of various cardiovascular diseases
Time of Update: 2022-05-01
A new study published in the academic journal "Nature-Medicine" has pointed out that the risk of cardiovascular disease complications may increase from one month to one year after contracting the new coronavirus .
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New DNA computer can assess water quality
Time of Update: 2022-04-30
The device consists of 8 small test tubes that glow green when contaminants are detected .
' "Cell-free synthetic biology allows us to take these small-molecule taste buds and put them in a test tube .
