-
Wang Yingxiang's team at Fudan University revealed the molecular mechanism of gene silencing in meiosis recombinant hot zones
Time of Update: 2022-10-13
Article link: Wang Yingxiang's team at Fudan University revealed the molecular mechanism of gene silencing in meiosis recombinant hot zonesMerosis is a special way of cell division necessary for eukaryotic sexual reproduction, which eventually produces haploid gametes.
-
Nature Methods, a diagram of a brain map
Time of Update: 2022-10-13
Combining open access data with transparent capabilities for standardizing and comparing brain maps, neurographs provide a systematic workflow for comprehensive structural and functional annotation-rich analysis of the human brain.
-
Nature Sub-Journal: Lysosomal Deletion Pathway
Time of Update: 2022-10-13
Original:GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway In a rare disease called mucolipid deposition type II, the heart and abdomen of the patient are swollen and skeletal deformities.
-
Xiao Lei's team revealed the regulatory role and loop mechanism of VTA D1 neurons on anxiety-like behavior
Time of Update: 2022-10-13
On October 4, 2022, Xiao Lei's team of young researchers from the Institute of Brain Sciences/State Key Laboratory of Medical Neurobiology of Fudan University published online on Molecular Psychiatry titled "D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via.
-
Antidepressants are designed to target the LSD psychedelic receptor 5HT2a without causing hallucinations
Time of Update: 2022-10-13
According to an article in the journal Nature ("5-HT2A Receptor Agonists Dock with a Customized Library of Antidepressant Activity"), researchers from the University of California, San Francisco, Unc Chapel Hill, and Yale, Duke and Stanford have successfully devised compounds that target key receptors activated by LSD without hallucinating 。 The antidepressant and anxiolytic effects produced by a single dose on mice can last for two weeks.
-
Cell Metabolism: Exercise and obesity have opposite effects on muscle and adipose tissue
Time of Update: 2022-10-13
Goodyear, a senior fellow in integrative physiology and metabolism at the Jocelyn Diabetes Center, collaborated with MIT's Computational Biology and Artificial Intelligence Laboratory, led by Dr. Manolis Kellis, to study the response of three metabolic tissues to exercise and high-fat diet-induced obesity with single-cell resolution.
-
Fantastic bioplastics
Time of Update: 2022-10-13
Working with more than a dozen industry partners dedicated to using this new technology, the project team will see how their bioplastics perform under different marine conditions, and how the materials break down.
-
A new mechanism of regulation of circular RNA in childhood asthma
Time of Update: 2022-10-13
On September 14, 2022, the team of Zhou Yufeng of our hospital and the research group of Qian Liling of the Children's Hospital of Fudan University published an article entitled circS100A11 enhances M2a macrophage activation and lunginflammation in children with asthma in the journal Allergy, a top journal in the field of allergy in the world.
-
Another possibility for Nature to overcome the barriers of cancer immunotherapy
Time of Update: 2022-10-13
Kenan professor of genetics and professor of microbiology and immunology at the University of North Carolina School of Medicine "Although activating the immune system to control malignancies has revolutionized cancer treatment, a significant proportion of patients do not respond to immunotherapy.
-
Bone age has become the "baton" of height development, and Yi Kexin AD has once again appeared in the height hot search list
Time of Update: 2022-10-13
The role of calcium is well known, but what parents do not know is that vitamins A and D are also essential nutrients in children's bone growth.
-
Nature corrects the textbook description of "telomeres"!
Time of Update: 2022-10-13
Nature, 2022; 609 (7929): 1048 Scientists at Nanyang Technological University in Singapore have mapped out the molecular structure of chromosomes known as the key parts of telomeres, which play a key role in aging and cancer.
-
Wang Chenzhu's research team revealed that bollworms feel the taste receptors of the plant's bitter substance coumarin
Time of Update: 2022-10-13
On October 8, 2022, Wang Chenzhu's research team at the Institute of Zoology of the Chinese Academy of Sciences published a report entitled "Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa" in the internationally renowned academic journal PLoS Genetics armigera's research paper revealed that the cotton bollworm taste receptor HarmGr180 is a receptor for the bitter substance coumarin, and is also involved in larval feelings for silyinoside (sinigrin) and strychnine.
-
The first to discover the guided defense jump gene: "Kipferl"
Time of Update: 2022-10-13
When the chaperone protein Kipferl (right) is mutated or missing, Rhino loses its affinity for the piRNA cluster sequence throughout the genome (green dot in left), but is isolated by a satellite array of surrounding entropy dots (green crescent in right).
-
The 3D map reveals the DNA tissue within human retinal cells
Time of Update: 2022-10-13
High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci" by Marchal C, Singh N, Batz Z, Advani J , Jaeger C, Corso-Diaz X, and Swaroop A, 7 October 2022, Nature Communications NIH researchers have revealed new insights into how gene structure determines gene expression, tissue-specific function, and disease phenotypes for blinding diseases.
-
Single-cell sequencing technology reveals key processes in acute kidney injury
Time of Update: 2022-10-13
Acute kidney injury (AKI) is a common complication associated with a variety of conditions, particularly affecting patients in intensive care units. However, the underlying mechanisms of AKI are not
-
Qian Weiqiang's research group has made new progress in the expression of nitrogen starvation regulated transposons in Arabidopsis
Time of Update: 2022-10-13
JIPB recently published a research paper by Qian Weiqiang's research group of the School of Modern Agriculture of Peking University entitled "Nitrogen starvation induces genome-wide activation of transposon elements in Arabidopsis" 。 Using a forward genetic approach, the study identified glutamate synthase (GLU1) that affects transcriptional level gene silencing, and combined with a series of molecular biology and genetic experiments, explored the effect of nitrogen starvation on activated transposon expression.
-
New epigenetic markers for aggressive prostate cancer
Time of Update: 2022-10-13
Professor Susan Clark, head of the Epigenetic Research Laboratory and principal investigator of the study, said: "Prostate cancer patients need more personalized treatment based on the nature of their tumor, and without new biomarkers, they cannot access this treatment because these biomarkers can better predict the risk of developing this deadly disease.
-
Cell: Dietary supplementation improves antibiotic-induced graft-versus-host disease after stem cell transplantation
Time of Update: 2022-10-13
D Image source: MD Anderson Cancer CenterAccording to a study published in the journal Cell, researchers at the University of Texas MD Anderson Cancer Center have identified a specific gut bacterium associated with advances in antibiotic therapy for allogeneic hematopoietic stem cell transplantation (allogeneic-hsct) for post-graft-host disease (GVHD) and found that nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models.
-
Scientists have discovered the main pathway to repair lysosomes in cells
Time of Update: 2022-10-13
Lysosomes are digestive enzyme sacs that organize cells by breaking down waste products. But they can also cause trouble: When their outer surface is damaged, their destructive proteins begin to spil
-
Kun Zhang's lab published a paper in BIOLOGY of REPRODUCTION
Time of Update: 2022-10-13
：Linker histone H1FOO is required for bovine preimplantation development by regulating lineage specification and chromatin structure(dagger)（IF=4.
：Linker histone H1FOO is required for bovine preimplantation development by regulating lineage specification and chromatin structure(dagger)（IF=4.
