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Why does tumor immunotherapy need genetic testing?
Time of Update: 2022-09-06
They are single-handed weapons with strong combat effectiveness, and each T cell targets only one type of bad guy; therefore, there are many T cells in the human body, enough to recognize all kinds of tumor cells or foreign viruses .
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Review and interpretation of the series of lung cancer surgery studies of the Japanese Clinical Oncology Research Group
Time of Update: 2022-09-06
JCOG0804/WJOG4507L is a single-arm, non-randomized, validated trial evaluating the efficacy and safety of lobectomy (wedge resection and pulmonary segment resection) in GGO-dominated peripheral lung cancer, with the primary endpoint being 5-year recurrence-free survival.
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Eur Urol: Prostate-specific membrane antigen radiation-guided surgery for detection of lymph node metastases in patients with prostate cancer
Time of Update: 2022-09-06
Prostate-specific membrane antigen Radioguided Surgery to Detect Nodal Metastases in Primary Prostate Cancer Patients Undergoing Robot-assisted Radical Prostatectomy and Extended Pelvic Lymph Node Dissection: Results of a Planned Interim Analysis of a Prospective Phase 2 Study.
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J Clin Oncol: Novel bispecific antibody ABBV-383 shows initial efficacy in relapsed/refractory multiple myeloma
Time of Update: 2022-09-06
ABBV-383, a B cell maturation antigen × CD3 T cell-binding bispecific antibody, has shown promising results in an ongoing first-in-human Phase I study in relapsed/refractory multiple myeloma (RRMM) result .
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"Nature" sub-published strong evidence: postoperative ctDNA-MRD analysis can predict the benefit of adjuvant chemotherapy in NSCLC!
Time of Update: 2022-09-06
▲Using ctDNA to predict postoperative dynamic recurrence risk and benefit of adjuvant chemotherapy in NSCLCA total of 116 patients with NSCLC who underwent surgical resection were included in this prospective study, 13 of whom discontinued treatment for various reasons and were therefore excluded from subsequent analyses, culminating in targeted NGS on tumor tissue and plasma samples from 103 patients detection .
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European Radiology: The value of MRI in predicting early recurrence of colorectal cancer patients with liver metastases
Time of Update: 2022-09-06
The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study.
The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study.
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European Radiology: first attempt at breast cancer imaging with CEST MRI
Time of Update: 2022-09-06
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
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Cancer Res: Tang Fu-Hui/Cui Heng/Ji Jia-kui collaborate to reveal molecular regulatory mechanisms for high-grade serous ovarian cancer
Time of Update: 2022-09-06
In order to fully reveal the molecular characteristics and interplay between different omics levels of high-grade serous ovarian cancer in the process of occurrence and development, Tang Fuhui Research Group of Peking University Biomedical Frontier Innovation Center cooperated with Cui Heng Research Group of Peking University People's Hospital and Ji Jiakui Research Group of Tsinghua University to conduct high-precision single-cell multi-omics sequencing analysis (genome (copy number variation), chromatin status group, DNA methylation group, transcriptome.
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Imaging diagnosis of liver cancer
Time of Update: 2022-09-06
The location of the lesions can be judged by the location of intrahepatic blood vessels, gallbladder and ligaments, and the qualitative diagnosis of some liver cancers can also be judged by the echo characteristics of the tumor .
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JAMA sub-issue: 6-year follow-up study of more than 4.5 million Koreans: quit drinking but increase cancer risk?
Time of Update: 2022-09-06
The increased group had a higher risk of alcohol-related cancer and all cancers compared with the maintainer group at each drinking level .
The increased group had a higher risk of alcohol-related cancer and all cancers compared with the maintainer group at each drinking level .
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A novel mechanism of the blockbuster oncogene CREB1 in the regulation of cancer cell plasticity
Time of Update: 2022-08-20
Recently, the team of Professor Qu Lianghu and Yang Jianhua from the School of Life Sciences of Sun Yat-sen University published a research paper entitled "CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathway" in Science China Life Sciences .
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Science sub-journal: Unlocking a new strategy for in vivo editing of CAR-M for post-operative immunotherapy of glioma
Time of Update: 2022-08-20
▲Research ideas for "local" MΦ in situ CAR structure editing around the tumor cavity after surgery and its targeted clearance of GSCs Image source: ReferencesIt is worth mentioning that the researchers published a related research paper entitled: "Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy" in Science Translational Medicine on August 3 .
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【2022 WCLC】Professor Wu Yilong: Dual drive, dual precision!
Time of Update: 2022-08-20
At the recently held World Conference on Lung Cancer (WCLC), a number of recent results related to MET amplification/overexpression were announced, including the use of sivotinib + osimertinib combination therapy for EGFR mutation-positive and Results of the Phase II SAVANNAH clinical study in osimertinib-resistant patients .
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WCLC 2022 Exploration of first-line immune combination therapy for ES-SCLC, 3-year follow-up results of KEYNOTE-604 study released!
Time of Update: 2022-08-20
Research BackgroundPhase III study KEYNOTE-604 suggested that pembrolizumab combined with EP as first-line treatment of ES-SCLC patients could significantly improve PFS compared with placebo combined with EP (HR=0.
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Resection of acoustic neuroma by subperineuronal dissection
Time of Update: 2022-08-20
】 Research Background With the development of microneurosurgery technology, surgical equipment and intraoperative electrophysiological monitoring, complete resection of acoustic neuromas (VSs) and postoperative facial nerve function preservation have improved significantly, and hearing preservation has gradually become a surgical pursuit .
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WCLC interview with Professor Dong Xiaorong: Radiotherapy has always played a role in the treatment of lung cancer
Time of Update: 2022-08-20
Could you please introduce the therapeutic status of radiotherapy in patients with early-stage, locally advanced and metastatic NSCLC?Professor Dong Xiaorong: Surgery, radiotherapy and chemotherapy are the three traditional methods of tumor treatment .
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Iso's example of early conversion, more benefits, high-risk multiple myeloma case analysis
Time of Update: 2022-08-20
A patient with HRMM treated with VRd regimen (bortezomib, lenalidomide, dexamethasone) developed adverse events such as rash and peripheral neuritis .
A patient with HRMM treated with VRd regimen (bortezomib, lenalidomide, dexamethasone) developed adverse events such as rash and peripheral neuritis .
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Academician Xu Binghe: Just like a slight awn, creating a torch and becoming a positive, "Chinese wisdom" in the field of breast cancer leads the world trend
Time of Update: 2022-08-20
At the same time, Academician Xu Binghe Zhandao hopes that more original Chinese research will be published, which can change the clinical practice of breast cancer in China and even the world .
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Based in China, looking to the world｜Following the new progress of MM, exploring new ideas of diagnosis and treatment, CACA guideline tour and POST-EHA/ASCO MM special meeting was successfully held!
Time of Update: 2022-08-20
On August 7, 2022, the China Anti-Cancer Association Hematology and Tumor Diagnosis and Treatment Guidelines Tour and POST-EHA/ASCO MM sponsored by the China Anti-Cancer Association Hematology and Tumor Professional Committee, the Hematology Hospital of the Chinese Academy of Medical Sciences and the National Hematological Disease Clinical Medical Center The special meeting was successfully held .
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Focusing on the progress of 2022WCLC, interpreting the research on NSCLC biomarkers
Time of Update: 2022-08-20
TP53 co-mutation was more common in MET exon 14 skipping mutant squamous cell carcinoma tissues (90.
MET Exon 14 Skipping Mutation in Non-Small Cell Lung Cancer (NSCLC) by Specific Mutation, Histology, and Smoking History.
