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J Clin Oncol: Novel bispecific antibody ABBV-383 shows initial efficacy in relapsed/refractory multiple myeloma

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Multiple myeloma (MM) is the second most prevalent hematological malignancy worldwide

ABBV-383, a B cell maturation antigen × CD3 T cell-binding bispecific antibody, has shown promising results in an ongoing first-in-human Phase I study in relapsed/refractory multiple myeloma (RRMM) result

The study enrolled patients with RRMM who had received at least three previous lines of therapy (including proteasome inhibitors, immunomodulatory drugs, and anti-CD38 monoclonal antibodies) to receive intravenous infusion of ABBV-383 every 3 weeks

As of January 8, 2022, a total of 124 patients (dose escalation [0.

Among evaluable patients (n=122), the objective response rate (ORR) was 57%, and the very good partial response or better (≥VGPR) rate was 43%

In conclusion, ABBV-383 was well tolerated in patients with RRMM, with an objective response rate of 68% at doses ≥ 40 mg

Original source:

D'Souza Anita, Shah Nina, Rodriguez Cesar et al.

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