-
Research progress of personalized neoantigen tumor vaccines
Time of Update: 2022-09-06
Furthermore, the enhanced neoantigen-specific T cell responses of these vaccines have the potential to persist and provide post-treatment immune memory, which offers the possibility of long-term prevention of disease relapse .
-
【Nature】The big move!
Time of Update: 2022-09-06
"By combining the screened modifier genes with existing CARs, the researchers were able to engineer T cells to eliminate tumor cells more efficiently .
"By combining the screened modifier genes with existing CARs, the researchers were able to engineer T cells to eliminate tumor cells more efficiently .
-
J Clin Oncol: Sacituzumab govitecan in endocrine-resistant HR+/HER2– advanced breast cancer
Time of Update: 2022-09-06
The prognosis of patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) endocrine-resistant metastatic breast cancer treated with sequential single-agent chemotherapy is poor .
-
Cancer Cell: BioNTech new paper - tumor neoantigen vaccine + chemotherapy + PD-1, a three-pronged approach to treat lung cancer
Time of Update: 2022-09-06
The study reports a phase 1b clinical trial combining the individualized neoantigen cancer vaccine NEO-PV-01 with chemotherapy and the anti-PD-1 drug pembrolizumab in metastatic non-squamous non-small cell lung cancer.
-
JAMA sub-issue: 270,000 people were followed up for 12 years: exercise can reduce cardiovascular and cancer risks!
Time of Update: 2022-09-06
Although there is strong evidence that physical activity has a beneficial role in longevity, there is little insight into how engaging in the same amount of different leisure-time activity types (such as running and cycling) is associated with mortality risk, and whether some activities compare to others There are greater benefits that are poorly understood .
-
MRI can detect early liver cancer, primary liver cancer has high incidence in my country
Time of Update: 2022-09-06
CT can detect early-stage liver cancer with a diameter of about 1 cm, and the main coincidence rate for clinical diagnosis and examination of liver cancer is as high as 90%; while MRI can greatly improve the incidence of liver cancer when using a new type of hepatocyte-specific contrast agent, Pumex.
-
Implementation guidelines for multidisciplinary team diagnosis and treatment of stage IV primary lung cancer in China
Time of Update: 2022-09-06
Excerpt Although patients with stage IV primary lung cancer have a variety of treatment options, due to the complexity of the disease and the heterogeneity of the disease, the problems that arise in
-
The Lancet: Update on the world's largest real-life prospective study!
Time of Update: 2022-09-06
KBP-2020 is similar to two previous KBP studies to compare and capture trends in lung cancer patient and tumor characteristics over the past 20 years .
KBP-2020 is similar to two previous KBP studies to compare and capture trends in lung cancer patient and tumor characteristics over the past 20 years .
-
Why does tumor immunotherapy need genetic testing?
Time of Update: 2022-09-06
They are single-handed weapons with strong combat effectiveness, and each T cell targets only one type of bad guy; therefore, there are many T cells in the human body, enough to recognize all kinds of tumor cells or foreign viruses .
-
European Radiology: The value of MRI in predicting early recurrence of colorectal cancer patients with liver metastases
Time of Update: 2022-09-06
The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study.
The growth pattern of liver metastases on MRI predicts early recurrence in patients with colorectal cancer: a multicenter study.
-
"Nature" sub-published strong evidence: postoperative ctDNA-MRD analysis can predict the benefit of adjuvant chemotherapy in NSCLC!
Time of Update: 2022-09-06
▲Using ctDNA to predict postoperative dynamic recurrence risk and benefit of adjuvant chemotherapy in NSCLCA total of 116 patients with NSCLC who underwent surgical resection were included in this prospective study, 13 of whom discontinued treatment for various reasons and were therefore excluded from subsequent analyses, culminating in targeted NGS on tumor tissue and plasma samples from 103 patients detection .
-
JAMA sub-issue: 6-year follow-up study of more than 4.5 million Koreans: quit drinking but increase cancer risk?
Time of Update: 2022-09-06
The increased group had a higher risk of alcohol-related cancer and all cancers compared with the maintainer group at each drinking level .
The increased group had a higher risk of alcohol-related cancer and all cancers compared with the maintainer group at each drinking level .
-
Review and interpretation of the series of lung cancer surgery studies of the Japanese Clinical Oncology Research Group
Time of Update: 2022-09-06
JCOG0804/WJOG4507L is a single-arm, non-randomized, validated trial evaluating the efficacy and safety of lobectomy (wedge resection and pulmonary segment resection) in GGO-dominated peripheral lung cancer, with the primary endpoint being 5-year recurrence-free survival.
-
Eur Urol: Prostate-specific membrane antigen radiation-guided surgery for detection of lymph node metastases in patients with prostate cancer
Time of Update: 2022-09-06
Prostate-specific membrane antigen Radioguided Surgery to Detect Nodal Metastases in Primary Prostate Cancer Patients Undergoing Robot-assisted Radical Prostatectomy and Extended Pelvic Lymph Node Dissection: Results of a Planned Interim Analysis of a Prospective Phase 2 Study.
-
Science: Kawaiilong team reveals mechanism of action of new CRISPR tool capable of cutting proteins
Time of Update: 2022-09-06
Gootenberg of the Massachusetts Institute of Technology in the United States teamed up, respectively, titled: RNA-triggered protein cleavage and Paper on cell death by the RNA-guided type III-E CRISPR-Cas nuclease-protease complex .
-
Cancer Res: Tang Fu-Hui/Cui Heng/Ji Jia-kui collaborate to reveal molecular regulatory mechanisms for high-grade serous ovarian cancer
Time of Update: 2022-09-06
In order to fully reveal the molecular characteristics and interplay between different omics levels of high-grade serous ovarian cancer in the process of occurrence and development, Tang Fuhui Research Group of Peking University Biomedical Frontier Innovation Center cooperated with Cui Heng Research Group of Peking University People's Hospital and Ji Jiakui Research Group of Tsinghua University to conduct high-precision single-cell multi-omics sequencing analysis (genome (copy number variation), chromatin status group, DNA methylation group, transcriptome.
-
European Radiology: first attempt at breast cancer imaging with CEST MRI
Time of Update: 2022-09-06
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
Breast cancer imaging with glucosamine CEST (chemical exchange saturation transfer) MRI: first human experience.
-
Imaging diagnosis of liver cancer
Time of Update: 2022-09-06
The location of the lesions can be judged by the location of intrahepatic blood vessels, gallbladder and ligaments, and the qualitative diagnosis of some liver cancers can also be judged by the echo characteristics of the tumor .
-
J Clin Oncol: Novel bispecific antibody ABBV-383 shows initial efficacy in relapsed/refractory multiple myeloma
Time of Update: 2022-09-06
ABBV-383, a B cell maturation antigen × CD3 T cell-binding bispecific antibody, has shown promising results in an ongoing first-in-human Phase I study in relapsed/refractory multiple myeloma (RRMM) result .
-
CT diagnosis and TNM staging of gastric cancer, everything you want to know is here
Time of Update: 2022-09-06
【Diagnostic opinion】 Gastric cancer in the gastric antrum (T4N3 stage) The tumor in this case broke through the serosal layer, the boundary with the left lobe of the liver and the uncinate process of the pancreas was unclear, and the fat interface disappeared.
