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CDK4/6: New insights into old targets
Time of Update: 2022-02-20
▎WuXi AppTec's content team edits the role of CDK4/6 in promoting cell cycle progression.
Today, the WuXi AppTec content team will share some of the wonderful content with readers,
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JAMA Netw Open: New study reveals the optimal treatment time for patients with aneurysmal subarachnoid hemorrhage - within 12.5 hours after onset!
Time of Update: 2022-02-20
Association of Onset-to-Treatment Time With Discharge Destination, Mortality, and Complications Among Patients With Aneurysmal Subarachnoid Hemorrhage .
Association of Onset-to-Treatment Time With Discharge Destination, Mortality, and Complications Among Patients With Aneurysmal Subarachnoid Hemorrhage leave a message here
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Mechanism of Infiltration Barrier in Transforming "Cold Tumor" into "Hot Tumor" by Improving T Cell Infiltration (1)
Time of Update: 2022-02-20
This result suggests that activation of Wnt/β-catenin signaling and deficient BATF3 DCs mediate T cell rejection and tumor cell escape from the immune system .
In a mouse melanoma model, A2AR inhibition increased T lymphocyte infiltration and resulted in improved tumor control, suggesting a potential role of ADO signaling in promoting T cell rejection .
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Molecular Cancer Tang Hailin/Wang Jin/Xiao Xiangsheng of Sun Yat-sen University discovered the potential molecular mechanism of breast cancer liver metastasis
Time of Update: 2022-02-20
On January 24, 2022, Sun Yat-Sen University, Tang Hailin, Wang Jin and Xiao Xiangsheng published a joint communication in Molecular Cancer (IF=27) online entitled "The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin”, which identified circROBO1 by RNA sequencing from three pairs of primary BC and metastatic liver sites .
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Heart: Increased oxidative stress and ventricular aneurysms predict cardiac sarcoidosis risk
Time of Update: 2022-02-20
U-8-OHdG levels and concomitant VA are strong predictors of first-time sustained ventricular tachycardia/sudden cardiac death in patients with cardiac sarcoidosis, which facilitates stratification of cardiac events and provides insights into ventricular Information about tachycardia .
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Clin Cancer Res: Cabozantinib Monotherapy for Advanced Soft Tissue Sarcoma
Time of Update: 2022-02-20
High levels of activated MET receptors have been reported in various sarcoma cell lines, coupled with elevated vascular endothelial growth factor (VEGF) levels in patients with STS, suggesting the use of the multi-receptor tyrosine kinase inhibitor cabozantinib Dual targeting of the VEGF and MET pathways by nisin would yield clinical benefit in this population .
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NEJM: Cardiovascular disease and cancer risk in tofacitinib-treated rheumatoid arthritis patients
Time of Update: 2022-02-20
Combining doses of tofacitinib with a TNF inhibitor was compared in a population at cardiovascular risk, with a higher risk of MACE and cancer in the tofacitinib group and some adverse events more frequently with tofacitinib .
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Cancers: Efficacy of conventional therapy (CT, chemotherapy with or without targeted therapy) after treatment failure in dMMR/MSI metastatic colorectal cancer (mCRC)
Time of Update: 2022-02-19
Mismatch repair deficient/microsatellite instability (dMMR/MSI) metastatic colorectal cancer (mCRC) with immune checkpoint inhibitor (ICI) progression followed by conventional therapy (CT, chemotherapy with or without targeted therapy) efficacy is unclear .
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BMC Cancer: Baseline Serum Cholinesterase (ChE) as an Independent Prognostic Indicator in Patients with Non-Small Cell Lung Cancer (NSCLC)
Time of Update: 2022-02-19
Studies have shown that baseline serum cholinesterase (ChE) can be used as an independent prognostic indicator in patients with non-small cell lung cancer (NSCLC) .
Studies have shown that baseline serum cholinesterase (ChE) can be used as an independent prognostic indicator in patients with non-small cell lung cancer (NSCLC) .
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Quit drinking always quit?
Time of Update: 2022-02-19
Chile and Brazil recently described the alcohol-induced cancer burden:In both countries,Alcohol consumption is estimated to be the third preventable cause of cancer morbidity and mortality, accounting for 3.
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Imfinzi in combination with tremelimumab shows OS-prolonging benefit in liver cancer
Time of Update: 2022-02-19
AstraZeneca recently announced more results from the Phase III HIMALAYA study, saying the addition of tremelimumab to its PD-L1 blocker Imfinzi (durvalumab) reduced the risk of death by 22% in patients with unresectable liver cancer .
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Towards precision and intelligence, minimally invasive surgery adds value to the treatment of early-stage lung cancer
Time of Update: 2022-02-19
At the launching ceremony, Shan Yong, Vice President of Medtronic Innovative Surgery China, said: " In addition to providing surgeons with various surgical tools, Medtronic Innovative Surgery has been committed to breaking through industry boundaries around major diseases, building a diagnosis and treatment ecosystem, and improving patients.
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Eur Urol Oncol: Intravesical VPM1002BC for non-muscle-invasive bladder cancer (NMIBC) recurrence after conventional BCG therapy
Time of Update: 2022-02-19
Recently, researchers from Switzerland published an article in "Eur Urol Oncol" to investigate the efficacy, safety, tolerability and efficacy of intravesical injection of VPM1002BC in patients with recurrent non-muscle invasive bladder cancer (NMIBC) following conventional BCG therapy.
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Imaging Collection: One sentence makes it easy for you to learn imaging diagnosis
Time of Update: 2022-02-19
Secondly, the tympanic membrane can also be blue when there is a fracture of the temporal bone and blood in the tympanic cavity .
The X-ray characteristics of acute osteomyelitis of long bones are: one viscera, two destructions, three living chun; and sequestrum in the heel .
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Front Oncol: Characteristics and clinical prognosis of EGFR-mutant NSCLC with meningeal metastasis (LM)
Time of Update: 2022-02-19
Taken together, the study showed that osimertinib treatment had better clinical outcomes in patients with EGFR-mutant NSCLC after diagnosis of LM .
Taken together, the study showed that osimertinib treatment had better clinical outcomes in patients with EGFR-mutant NSCLC after diagnosis of LM .
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Front Oncol: EGFR-TKI combined with thymosin in the treatment of EGFR-mutant advanced non-small cell lung cancer (NSCLC) improves patient outcomes
Time of Update: 2022-02-19
Recently, a team from Xinqiao Hospital of Chongqing Military Medical University has carried out related research, mainly to explore the efficacy and safety of EGFR-TKI combined with thymosin in the treatment of advanced non-small cell lung cancer ( NSCLC ) patients with EGFR mutations .
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Molecular Cancer: First clinical trial: salivary exosomal small RNAs as esophageal cancer detection and prognostic markers
Time of Update: 2022-02-19
Collectively, this prospective clinical study showed that a dual signature composed of two small RNAs, tRNA-GlyGCC-5 and sRESE, could serve as a non-invasive biomarker for the diagnosis and prognosis of esophageal squamous cell carcinoma (ESCC) , It is also possible to determine which patients may benefit from adjuvant therapy prior to surgery .
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Eur Urol Focus: What are the long-term outcomes of thulium laser enucleation of the prostate?
Time of Update: 2022-02-19
Durability of ThuLEP efficacy was demonstrated by investigating long-term efficacy and morbidityThe study included all patients treated with ThuLEP at a tertiary referral center in Germany between 2009 and 2021, who were retrospectively followed to investigate whether prostate adenoma persisted, re-grown (ReIP), or had long-term complications.
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Nature Med: Combination of GD2 and CD47 antibody drug shows broad-spectrum anti-cancer potential
Time of Update: 2022-02-18
Majzner, Stanford University Nature Medicine Nature Medicine Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication Antitumor activity has been shown in multiple preclinical models including neuroblastoma, osteosarcoma, and small cell lung cancer .
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European Radiology: The value of multiparametric z-spectrum MRI in clinical glioma stratification
Time of Update: 2022-02-18
Recently , a study published in the journal European Radiology explored the ability of fitted Z-spectrum contrast maps and their combinations to simultaneously predict glioma grade, IDH genotype, and 1p/19q coding break status for a noninvasive assessment .
