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European Radiology: Can gadoxetate disodium-enhanced MRI performed at different institutions, different machines, and different field strengths still reflect the correlation between liver enhancement and liver function?
Time of Update: 2022-02-18
Okada et al are the first to report a multicenter study of the correlation between biochemical parameters and hepatobiliary phase enhancement using the liver-spleen ratio (LSR), showing that in an Asian cohort, thrombin activity, bilirubin, and total cholesterol levels were significantly correlated with liver enhancement .
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J Thorac Oncol: Lorlatinib is still effective after progression in patients with ALK+ NSCLC
Time of Update: 2022-02-18
NSCLCA retrospective analysis of the clinical benefit of continuation of lorlatinib in patients with progression (LBPD) in an ongoing phase II trial (NCT01970865) .
A retrospective analysis of the clinical benefit of continuation of lorlatinib in patients with progression (LBPD) in an ongoing phase II trial (NCT01970865) .
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Front Oncol: Academician Xu Binghe's team found that low expression of HER2 in HER2-breast cancer may be an indicator of good prognosis
Time of Update: 2022-02-18
Taken together, these studies suggest that HER2-low tumors are a clinically distinct type, especially in the HR-positive subgroup, and may be an indicator of good prognosis in HER2- breast cancer patients .
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Cell: Heavy!
Time of Update: 2022-02-18
In a new study published in Cell in the early morning of January 20, Beijing time , a research team from the University of Basel in Switzerland found that T cells can effectively eliminate abnormal or infected cells only in a magnesium-rich environment.
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Cell heavyweight: Liu Ruqian develops a new virus-like vector for safe and efficient in vivo gene editing
Time of Update: 2022-02-18
When it comes to Liu Ruqian, the first thing that comes to our mind are new gene editing tools such as Base Editor and Prime Editor . Different from CRISPR-Cas9 gene editing, a series of precise gene
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European Radiology: The value of multiparametric z-spectrum MRI in clinical glioma stratification
Time of Update: 2022-02-18
Recently , a study published in the journal European Radiology explored the ability of fitted Z-spectrum contrast maps and their combinations to simultaneously predict glioma grade, IDH genotype, and 1p/19q coding break status for a noninvasive assessment .
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Nature Med: Combination of GD2 and CD47 antibody drug shows broad-spectrum anti-cancer potential
Time of Update: 2022-02-18
Majzner, Stanford University Nature Medicine Nature Medicine Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication Antitumor activity has been shown in multiple preclinical models including neuroblastoma, osteosarcoma, and small cell lung cancer .
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Science Advances: Subverting Cancer Research: Anticancer drugs have outstanding preclinical effects, but they will not work in clinical practice. The problem is the oxygen concentration?
Time of Update: 2022-02-18
Science Advances Science Advances Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivityThe study showed that in preclinical studies, most of the cultured cancer cells were in a relatively high air oxygen concentration (21% oxygen concentration), while in reality tumors in vivo are usually in a hypoxic state (1%-2% oxygen concentration), This difference in oxygen concentration largely affects the sensitivity of cancer cells to targeted drugs .
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Cancers: Multicenter Study Explores Treatment, Prognosis, and Associated Factors in Locally Advanced Merkel Cell Carcinoma
Time of Update: 2022-02-18
Thirty-eight percent (57/150) of patients underwent sentinel lymph node biopsy (SLNB) after primary tumor resection, and 10.
Thirty-eight percent (57/150) of patients underwent sentinel lymph node biopsy (SLNB) after primary tumor resection, and 10.
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Radiology: How to deal with enlarged mediastinal lymph nodes accidentally discovered?
Time of Update: 2022-02-18
A study published in the journal Radiology assessed the frequency of mediastinal lymphadenopathy in NLST participants on the initial LCS CT scan and explored its association with increased numbers of lung cancers , providing further insights into incidental mediastinal lymphadenopathy.
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European Radiology: MRI radiomic features of mesorectal fat and prognosis in patients with rectal cancer
Time of Update: 2022-02-18
Recently, a study published in the journal European Radiology used MRI radiomics features to analyze mesorectal fat for non-invasive assessment and prediction of clinical prognosis and treatment effect in patients with locally advanced rectal cancer .
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Nature BME: Nanjing University Wu Jinhui's team transforms bacteria as cancer vaccines
Time of Update: 2022-02-18
Attempting to use the autoimmune system to attack tumor cells is an ideal anti-tumor therapy . After the tumor receives radiation, it releases a series of antigens . Ideally, these antigens can be u
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European Radiology: What do these signs suggest?
Time of Update: 2022-02-18
diagnosisA study published today in the journal European Radiology examines the differences in collagen fiber patterns (CFPs) between thymoma, thymic carcinoma, and lymphoma based on T2 and diffusion-weighted MRI , and evaluates their role in the differential diagnosis of thymic tumors.
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Molecular Cancer: Fudan University's team of Chen Tong, Zhang Si's team, Wang Biyun's team of Affiliated Cancer Hospital, and Fu Chaowei's team of School of Public Health provide high-sensitivity, non-invasive tumor chemotherapy liquid biopsy markers
Time of Update: 2022-02-18
Fu Chaowei from School of Public Health collaborated to discover a highly accurate, non-invasive tumor chemotherapy liquid biopsy marker: plasma small nucleolar RNA SNORD33 for triple-negative breast cancer Prediction of platinum-based drug sensitivity in cancer patients, and revealed the involvement of methylation-binding protein MeCP2 in the molecular mechanism of platinum-based drug resistance regulated by SNORD33 .
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Genetically engineered NK cell therapy receives FDA Fast Track designation, combined with monoclonal antibody for the treatment of advanced gastric cancer
Time of Update: 2022-02-18
It is reported that this is Celularity's third NK cell therapy to receive FDA Fast Track qualification in the past year.
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IJC: Peking University + Oxford study of 510,000 Chinese found that drinking alcohol can directly cause cancer
Time of Update: 2022-02-18
Men who did not drink alcohol had a 14% lower risk of cancer and a 31% lower risk of specific alcohol-related cancers, such as colon, esophagus and liver cancerTwo gene variants commonly found in East Asia (ALDH2 and ADH1B) reduce a person's tolerance to alcohol and reduce the body's ability to break down acetaldehyde, which can lead to a buildup in the blood of acetaldehyde, a form of acetaldehyde that is produced when the body metabolizes alcohol.
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J Clin Oncol: Efficacy of afatinib (afatinib) in combination with pembrolizumab (pembrolizumab) in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC): the ALPHA study
Time of Update: 2022-02-18
Recently, the Journal of Clinical Oncology published the research results of the Phase II clinical study ALPHA (NCT03695510) carried out by a team in Taiwan, China, mainly to evaluate Afatinib (afatinib) combined with Pembrolizumab (pembrolizumab) in the treatment of recurrent or Outcomes in patients with metastatic head and neck squamous cell carcinoma (HNSCC) .
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European Radiology: Deep Learning + Radiomics!
Time of Update: 2022-02-18
Recently, a study published in the journal European Radiology established and tested a model using DL and HCR radiomics signatures to predict the risk of recurrence in patients with STS undergoing surgical resection, while incorporating routinely applied staging systems and other studies.
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Clinical Lung Cancer: Delayed dosing of immune checkpoint inhibitors (ICIs) under the influence of the new crown epidemic does not affect the efficacy of NSCLC patients
Time of Update: 2022-02-18
. Recently, Clinical Lung Cancer published a retrospective study to evaluate the safety and efficacy of delayed administration (EI) of immune checkpoint inhibitor (ICI) in patients with non-small cell lung cancer under the influence of the new coronary pneumonia epidemic.
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Radiology: Infinite correlation between MRI and histopathology in prostate cancer!
Time of Update: 2022-02-18
Recently, a study published in the journal Radiology compared rates of biochemical recurrence (BCR), metastatic disease, and prostate cancer-specific mortality in patients with consistent and discordant local tumor extent in MRI and prostatectomy specimens .
