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Cancers: Multicenter Study Explores Treatment, Prognosis, and Associated Factors in Locally Advanced Merkel Cell Carcinoma

 Last Update: 2022-02-18
 Source: Internet
 Author: User

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Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a high risk of recurrence and a poor prognosis
.

Treatment of locally advanced MCC includes surgery and radiation therapy

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a high risk of recurrence and a poor prognosis

Among the 161 patients included, the median age was 72 years (30-94 years), 55.
9% were over 70 years old, and 49.
7% were male
.

About 77.

Among the 161 patients included, the median age was 72 years (30-94 years), 55.

Of the 161 patients treated, 96.

Of the 156 patients who underwent curative surgery, 81 received perioperative treatment (51.

With a median follow-up of 2.

In a multivariate Cox regression model, significant negative factors included: male sex (HR 1.
42, 95% CI 1.
06 - 3.
01), lymph node involvement (HR 5.
41, 95% CI 2.
39 - 12.
26), no clinical lymph node metastases and no SLNB (HR 5.
45, 95% CI 2.
41 - 12.
3), without perioperative radiotherapy (HR 2.
19, 95% CI 1.
29 - 3.
75)
.

The median OS was 6.
8 years (95% CI 3.
56 10.
03), and the 1-, 2-, and 5-year OS were 85%, 70%, and 55%, respectively
.

The median OS was 6.

In the multivariate Cox regression model, significant negative factors included: male (HR 1.
95, 95% CI 1.
16 3.
27), ≥70 years old (HR 2.
0, 95% CI 1.
15 3.
48), lymph node involvement (HR 3.
15, 95% CI 1.
49 6.
68) ), and patients without clinical lymph node metastases also had no SLNB (HR 2.
30, 95% CI 1.
10 4.
82)
.

In conclusion, this study analyzed the treatment, prognosis and related factors of locally advanced MCC, and suggested that the treatment should be performed by an experienced team
.

This study analyzed the treatment, prognosis and related factors of locally advanced MCC, and recommended treatment in an experienced team

Original source:

Dudzisz-Sledz, M.

Dudzisz-Sledz, M.
; Sobczuk, P.
; Kozak, K.
; Switaj, T.
; Kosela-Paterczyk, H.
; Czarnecka, AM; Falkowski, S.
; Rogala, P.
; Morysinski, T.
; Spalek, MJ; et al.
Treatment of Locally Advanced Merkel Cell Carcinoma—A Multi-Center Study.
Cancers 2022, 14, 422.
https://doi.
org/10.
3390/cancers14020422 https://doi.
org/10.
3390/ https :/ /doi.
org/10.
3390/ https://doi.
org/10.
3390/ leave a message here

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