European Radiology: Can gadoxetate disodium-enhanced MRI performed at different institutions, different machines, and different field strengths still reflect the correlation between liver enhancement and liver function?

 Gadoxetate disodium is a hepatocyte-specific contrast agent that exhibits selective hepatocyte uptake and peaks approximately 20 minutes after injection (hepatobiliary phase )
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Hepatobiliary phase images improve the detection rate of primary and secondary liver tumors by enhancing the contrast difference between diseased and healthy liver tissue

 Gadoxetate disodium is a hepatocyte-specific contrast agent that exhibits selective hepatocyte uptake and peaks approximately 20 minutes after injection (hepatobiliary phase )

Whether liver enhancement is still present on gadoxetate disodium -enhanced MRI in a multi-vendor cohort of patients with hepatocellular carcinoma collected in a prospective randomized controlled trial , published in the journal European Radiology The correlation between liver function and liver function provides a reference for further data aggregation and evaluation .
 

In a prospective multicenter phase II trial (SORAMIC), the present study evaluated images of 359 patients undergoing standardized gadoxetate disodium -enhanced MRI scans using different scanners .
Using univariate and multivariate analyses, liver enhancement on the hepatobiliary phase was analyzed in relation to biochemical laboratory parameters, clinical outcomes related to liver function, liver function grading systems (Child-Pugh and albumin-bilirubin [ALBI]), and scans correlation between instrument features .
 

Significant positive correlations were found between LSR and albumin (rho = 0.

193; p < 0.
001) , platelet count (rho = 0.
148; p = 0.
004), and sodium (rho = 0.
161; p = 0.

Significant positive correlations were found between LSR and albumin (rho = 0.
193; p < 0.
001) , platelet count (rho = 0.
148; p = 0.

Correlation between LSR and biochemical parameters .

Scatter plot of linear regression lines showing the relationship of LSR with statistically significant variables: (a) albumin (rho = 0.
193, p < 0.
001), (b) total bilirubin (rho = -0.

Correlation between LSR and biochemical parameters .
Scatter plot of linear regression lines showing the relationship of LSR with statistically significant variables: (a) albumin (rho = 0.
193, p < 0.
001), (b) total bilirubin (rho = -0.

The present study demonstrates that enhancement on the hepatobiliary phase of gadoxetate disodium -enhanced MRI in HCC patients correlates with liver function , regardless of underlying cirrhosis, across several centers and field strengths .
This emphasizes the importance of gadoxetate disodium -enhanced MRI as an imaging marker of liver function in the treatment decision-making process, and provides data support for the consistent assessment of patients' liver function and the wider application of liver-specific contrast agents .

Original source:

Original source:

Osman Öcal,Bora Peynircioglu,Christian Loewe.

Correlation of liver enhancement in gadoxetic acid-enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial.
DOI:10.
1007/s00330-021-08218-9

Osman Öcal,Bora Peynircioglu,Christian Loewe.
Correlation of liver enhancement in gadoxetic acid-enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial.
DOI:10.
1007/s00330-021-08218-9 Leave a comment here