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For prostate cancer patients, accurate clinical staging of local tumor extent is necessary for accurate prognosis, patient counseling, and management decisions
.
One of the most relevant aspects of prostate cancer staging is the determination of whether the tumor extends beyond the prostate (ie, TNM classification T3), which has a major impact not only on the patient's prognosis, but also on the choice of surgical approach .
For prostate cancer patients, accurate clinical staging of local tumor extent is necessary for accurate prognosis, patient counseling, and management decisions
Microscopically assessing tumor spread outside the prostate is challenging clinically , and MRI may provide complementary information about local tumor extent .
Recently, a study published in the journal Radiology compared rates of biochemical recurrence (BCR), metastatic disease, and prostate cancer-specific mortality in patients with consistent and discordant local tumor extent in MRI and prostatectomy specimens .
Risk assessment and treatment prognosis provide valuable auxiliary tools .
Extraprostatic progression and seminal vesicle invasion were assessed using a five-point Likert scale, with a score of 4 or greater being classified as positive
.
Biochemical recurrence (BCR), metastasis, and prostate cancer-specific mortality were estimated using Kaplan-Meier and Cox models
Extraprostatic progression and seminal vesicle invasion were assessed using a five-point Likert scale, with a score of 4 or greater being classified as positive
A total of 2160 patients were evaluated (median age, 60 years; interquartile range, 55-64 years)
Multivariate outcome analysis including interaction terms between MRI parameters and MRI tumor stage
Multivariate outcome analysis, includinginteraction terms between MRI parameters and MRI tumor stageIn conclusion , local tumor staging of prostate cancer on MRI is predictive of long-term oncologic outcomes when benchmarked against histopathologic assessment after prostatectomy .
Although these results need to be validated at other institutions and on different MRIs, the results could inform discussions on how best to integrate MRI into accurate clinical staging algorithms for prostate cancer .
In conclusion , local tumor staging of prostate cancer on MRI is predictive of long-term oncologic outcomes when benchmarked against histopathologic assessment after prostatectomy .
Although these results need to be validated at other institutions and on different MRIs, the results could inform discussions on how best to integrate MRI into accurate clinical staging algorithms for prostate cancer .
Original source :
Original source :Andreas G Wibmer , Ines Nikolovski , Joshua Chaim , et al .
Local Extent of Prostate Cancer at MRI versus Prostatectomy Histopathology: Associations with Long-term Oncologic Outcomes .
DOI: 10.
Andreas G Wibmer Ines Nikolovski Joshua Chaim ,et al Local Extent of Prostate Cancer at MRI versus Prostatectomy Histopathology: Associations with Long-term Oncologic Outcomes 10.
1148/radiol.
210875 10.
1148/radiol.
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