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Imfinzi in combination with tremelimumab shows OS-prolonging benefit in liver cancer

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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AstraZeneca recently announced more results from the Phase III HIMALAYA study, saying the addition of tremelimumab to its PD-L1 blocker Imfinzi (durvalumab) reduced the risk of death by 22% in patients with unresectable liver cancer

ASCO

The HIMALAYA study evaluated Imfinzi monotherapy and the STRIDE regimen, which consists of adding a single priming dose of tremelimumab to Imfinzi followed by Imfinzi every four weeks

AstraZeneca said the median survival time for patients on the STRIDE regimen was 16.

Tremelimumab is a human immunoglobulin (Ig) G2 monoclonal antibody directed against the human T cell receptor protein cytotoxic T lymphocyte-associated protein 4 (CTLA4) , with potential immune checkpoint inhibition and antitumor activity

immunity

Following a string of clinical failures with tremelimumab, AstraZeneca finally demonstrated last year that adding tremelimumab to Imfinzi+ chemotherapy significantly extended overall survival in lung cancer

lung cancer

Original source:

https://firstwordpharma.

https://firstwordpharma.
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