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Clin Cancer Res: Cabozantinib Monotherapy for Advanced Soft Tissue Sarcoma

 Last Update: 2022-02-20
 Source: Internet
 Author: User

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1 2 dibromopropane

cancer cell differentiation

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Soft tissue sarcoma (STS) is a rare and heterogeneous stromal tumor

We conducted an open-label, multi-institution, single-arm, phase II clinical trial of single cabozantinib in patients with aggressive advanced STS who had received at least one standard systemic therapy

The primary endpoints were overall response rate and 6-month progression-free survival (PFS)

Assess the patient's best response

The median treatment course was 4 (range 1-99)

Objective responses (all partial responses) were achieved in 6 (11.

progression-free survival

The most common grade 3-4 adverse reactions were hypertension (7.

side effects

In conclusion, cabozantinib alone has demonstrated modest resistance in STS patients with specific histologic subtypes (alveolar soft sarcoma, undifferentiated pleomorphic sarcoma, extraskeletal myxoid chondrosarcoma, and leiomyosarcoma).

Cabozantinib showed certain antitumor activity as a single drug Cabozantinib showed certain antitumor activity

Original source:

Geraldine O'Sullivan Coyne, et al.

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