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Eur Urol Oncol: Intravesical VPM1002BC for non-muscle-invasive bladder cancer (NMIBC) recurrence after conventional BCG therapy

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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Over time, Bacille Calmette-Guérin (BCG) has evolved into different types and is used in intravesical immunotherapy for non-muscle-invasive bladder cancer (NMIBC)

Some comparative clinical studies have shown differences in therapeutic effect between selected strains

VPM1002BC is a transgenic M.

To investigate the efficacy, safety, tolerability and quality of life of recurrent non-muscle invasive bladder cancer (NMIBC) after intravesical injection of VPM1002BC in the treatment of conventional BCG therapy.

The researchers designed a phase 1/2 single-arm trial (NCT02371447)

After excluding 2 ineligible patients, 40 patients were included in the full analysis group

Relapse-free rate at 60 weeks of treatment

In conclusion, almost half of the patients did not relapse after treatment with VPM100BC 1 year after the start of treatment

Almost half of the patients did not relapse after treatment with VPM100BC 1 year after the start of treatment Almost half of the patients did not relapse after treatment with VPM100BC 1 year after the start of treatment

Original source:

Cyrill A Rentsch, George N Thalmann, Ilaria Lucca et al.

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