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NEJM: Cardiovascular disease and cancer risk in tofacitinib-treated rheumatoid arthritis patients

 Last Update: 2022-02-20
 Source: Internet
 Author: User

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Compared with tumor necrosis factor (TNF) inhibitors, tofacitinib increases blood lipid levels and cancer risk

rheumatoid arthritis cardiovascular

In a study published today in the top medical journal NEJM, researchers conducted a randomized, open-label, non-inferiority, authorized, safety endpoint trial

The study's co-primary endpoints were adjudicated MACE and cancer, excluding non-melanoma skin cancer

A total of 1455 patients received tofacitinib 5 mg twice daily, 1456 patients received tofacitinib 10 mg twice daily, and 1451 patients received TNF inhibitor therapy

Infect

CONCLUSIONS: Combining doses of tofacitinib and a TNF inhibitor was compared in a population at cardiovascular risk, with a higher risk of MACE and cancer in the tofacitinib group, and some adverse events more frequently with tofacitinib

Combining doses of tofacitinib with a TNF inhibitor was compared in a population at cardiovascular risk, with a higher risk of MACE and cancer in the tofacitinib group and some adverse events more frequently with tofacitinib

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