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Eur Urol: Prostate-specific membrane antigen radiation-guided surgery for detection of lymph node metastases in patients with prostate cancer

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Extended pelvic nodule dissection (ePLND) is the gold standard for staging of prostate cancer (PCa) nodules

Recently, researchers from Italy published an article in "Eur Urol" describing the interim analysis results of a phase 2 prospective study (NCT04832958) of PSMA-RGS during RARP

The study was a phase 2 trial designed to enroll 100 patients with intermediate- or high-risk cN0cM0 PCa diagnosed on routine imaging with >5% risk of LNI

All patients underwent 68Ga-PSMA positron emission tomography (PET)/magnetic resonance imaging; 99mTc-PSMA-I&S was synthesized and injected intravenously the day before surgery, followed by single photon emission computed tomography/computed tomography

Four (33%), six (50%), and two (17%) patients in the study had intermediate-risk, high-risk, and locally advanced PCa, respectively

Diagnostic accuracy of individual patients

In conclusion, robotic-assisted PSMA-RGS is a safe and feasible method in primary staging with good specificity but poor sensitivity and may miss micrometastatic nodular disease

Original source:

Giorgio Gandaglia, Elio Mazzone, Armando Stabile et al.

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