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Chemical exchange saturation transfer (CEST) MRI, as an emerging imaging technique, can obtain images of endogenous cellular components or exogenous preparations containing exchangeable protons, and has attracted more and more attention
Given the high sensitivity of glucose at the molecular level and the known enhanced uptake of glucose by tumors, the use of glucose as a new molecular imaging method for tumor diagnosis has been proposed
A study published in the journal European Radiology investigates the feasibility of translating the GlcN CEST MRI method into a clinical MRI device to obtain a new class of breast cancer MRI contrast agents and compares it with conventional MRI methods
The study recruited 12 newly diagnosed breast cancer patients (median age, 53 years) from August 2019 to March 2020
GlcN CEST MRI showed higher signal intensity in tumor tissue compared to surrounding breast tissue (8.
This preliminary feasibility study demonstrates that GlcN CEST MRI has the potential to diagnose breast cancer in clinical practice
Original source:
Michal Rivlin, Debbie Anaby, Noam Nissan, et al.