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NATURE: What does nerve and adipose tissue communicate?
Time of Update: 2020-07-30
Mutations in the !---- leptin gene (ob) can lead to metabolic disorders, including severe obesity, as well as heat-producing and fat-producing defects, both of which are regulated by the sympathetic nervous system.
the effects of leptin on nerve domination are mediated by agouti-related peptides and pro-piomelanocortin neurons in the thalamus archonuclear nucleus.
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Cells: Why do we have a bigger brain?
Time of Update: 2020-07-30
, a study published online by the leading academic journal Cell reveals an important mechanism for the human brain to expand in the white matter region during embryonic development.
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Sci Adv: ARID1A deficiency promotes epinephrine-interstitial transformation of neuroblastoma cells.
Time of Update: 2020-07-30
concluded that the absence of ARID1A led to changes in the distribution of BAF and PBAF complexes in enhancers, which in turn regulated the activity of the enhanced daughter and altered gene expression levels, further leading to the transformation of neuroblastoma cells from ADRN cells to MES cells, resulting in greater migration and resistance.
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Mol Brain: Excess prodonicacid in food additives can cause abnormal brain development!
Time of Update: 2020-07-30
27, 2020 /PRNewswire/ -- A team led by Dr. Mun Ji-young has revealed the mechanisms that cause autism caused by an imbalance in the human gut microbe, the Korean Institute of Brain Research (KBRI, led by Suh Pann-hill) announced.
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Cell: Identification of genetic networks induced by amyloid plaques in Alzheimer's disease.
Time of Update: 2020-07-30
"We focused on transcription changes near amyloid plaques (50 microns in circumotherum," " explained Wei-Ting Chen, co-author of the two gene co-expression network papers and a postdoctoral researcher on the De Strooper team.
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Counting: Shortest time! Chinese scholars have surpassed 100 CNS achievements in the field of life sciences; Gao Fu/Rao Zi and/Qinchuan have more than 4 articles; and Shanghai University of Science and Technology and Shandong Agricultural University have performed well.
Time of Update: 2020-07-30
, January 16, 2020, He Chuan, University of Chicago, Beijing Genomics Institute of the Chinese Academy of Sciences Han Kea and Tongji University Gao Yawei joint newsletter in Science online entitled "N6-methyladenosine of chromosome-type-regulatoryed RNA" Regulates chromatin state and ion" research paper, which showed that knocking out m6A catalytic protein Mettl3 or nuclear-identified protein Ythdc1 in mouse embryonic stem cells increased the accessibility of chromatin and activated transcription in m6A-dependent manners.
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Nat Commun : Zhang Jun group reveals the important role of the hypothalamus orexin nervous system in THE maintenance of REM sleep stability.
Time of Update: 2020-07-30
Zhang Jun, a research group in the Department of Physiology and Research at the Basic Medical College of the Army Military Medical University (formerly the Third Military Medical University), published a study in communications magazine entitled Orexin Signaling Modulates synced excitation in the sublaterodorsal tegmental quis to REM sleep, which was first clearly reported on the direct involvement of the hypothalamus orexin nervous system in rapid eye movement (REM) sleep regulation, and the resolution of the system's molecular and neuro-neuro-mechanism.
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Dudsy Muscular Dystrophy (DMD) Gene Therapy! FDA grants Sarepta/Roche SRP-9001 Fast Track qualification!
Time of Update: 2020-07-30
at the end of June, Sarepta announced that it had completed rolling applications for new drugs (NDA) to the FDA to seek accelerated approval of Casimersen (SRP-4045), a phosphoric acid diamide protomelobody (PMD) for dMD patients with genetically confirmed mutations that are suitable for skipping exon 45 treatment.
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The treatment of eclampto dementia has been welcomed! Experimental gene therapy PR006.
Time of Update: 2020-07-30
!----, a biotechnology company dedicated to gene therapy for neurodegenerative diseases, prevail today announced that the U.S. Patent and Trademark Office (USPTO) has issued a U.S. patent number 10689625 on June 23, 2020, involving PR0006's AAV vector.
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Cell: Myelin cell immune signaling hub - TREM2.
Time of Update: 2020-07-30
The physiological effects of the TREM2 signal and its regulatory strategy TREM2 in a specific environment, i.e. in the brain and bones, TREM2 plays a very important role in tissue development and functional maintenance, and TREM achieves this function by expressing small glial cells and bone-breaking cells in myelin cells.
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Nature: Revealing the brain's sensory gating system!
Time of Update: 2020-07-30
in the new study, researchers try to learn more about specific types of neurons found in TRN in the hope of finding new ways to treat ADHD and attention deficit.
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Different brain haemorrhage period MRI performance, do you have it?
Time of Update: 2020-07-30
Figure 5 Acute early MRI performance of cerebral hemorrhage subacute (pictured from the reference s1) at the late subacute stage, or subacute "maturation", the red blood cells at the hematoma site are dissolved, deoxygenated hemoglobin becomes high-iron hemoglobin, MRI is shown as a high T1 signal, T2 low signal.
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Cell: Chen Wei/Lu Yi, etc. reveals how the brain copes with Alzheimer's amyloid deposition plaques?
Time of Update: 2020-07-30
the study found no synergy in the brains of normal mice, however, with the accumulation of beta-amyloid, 57 PIGs gradually constructed a regulatory network dominated by astrocytes and nerve gum cells (see figure below).
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Eur Heart J: Eat vegetables, fruits and dairy products regularly to prevent stroke! Nearly 420,000 people in nine European countries studied it.
Time of Update: 2020-07-30
Recently published EPIC studies of nearly 420,000 people show that regular consumption of fruits and vegetables, dietary fiber, dairy products is associated with a reduced risk of cerebral infarction, while eating eggs regularly increases the risk of cerebral hemorrhage.
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July 17, 2020 Science Journal.
Time of Update: 2020-07-30
In a new study, , by focusing on cytokine milieu and immune cells near TGF-beta reactive TIC, the researchers determined how TIC sepulks produce a spatially unique niche microenvironment, which is necessary for SCC's leaching progression and resistance.
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Cell: Cd4 plus T cells are present in the brain and affect the maturation of the brain's immune "sentinel".
Time of Update: 2020-07-30
, July 22, in a study published in the journal Cell, Adrian Liston and others found that there are CD4-T cells in healthy brains that affect the maturation of small glial cells.
, or CD4-T, plays a role in the maturation of glial cells in the brain.
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Chest: Sleep disorders and cognitive changes after severe illness.
Time of Update: 2020-07-30
7 days after discharge from the ICU, no activity recorded estimated sleep estimate variables that predicted cognitive impairment or persistent sleep disorders in survivors at 6 and 12 months of follow-up.
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Fat burning is not active, nerve problem? The leptin finder team Nature has published its latest report.
Time of Update: 2020-07-30
However, the real magic change will not take until two weeks after the continued injection of leptin, the white fat stored in the mice begins to break down normally, and another type of fat tissue, brown fat, returns to fat-burning heat, and the animals begin to lose weight.
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Cell: Significant progress! Explain the real causes of chicken skin.
Time of Update: 2020-07-30
sympathetic nerve's response to the cold is to shrink the vertical hair muscle in a short period of time and cause goose bumps, and promote hair follicle stem cell activation and new hair growth in the long term.
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Cell: Heavyweight! For the first time, a small number of auxiliary T-cells have been found in the brain and their new role in brain development has been revealed.
Time of Update: 2020-07-30
In a ground-breaking study , researchers from the VIB Brain and Disease Research Centre in Belgium, the University of Leuven and the Babrahan Institute in the UK described a dedicated population of brain-resident immune cells found in the brains of mice and humans, and found that the presence of white blood cells was crucial to the normal development of the mouse brain.
