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Do patients with chronic inflammatory skin disease affect the incidence of inflammatory bowel disease?
Time of Update: 2022-08-16
. Methods : In this cohort study, we used nationwide longitudinal commercial insurance claims data in the United States to identify adults and children who were seen by a dermatologist with a diagnosis of psoriasis, atopic Dermatitis, alopecia areata, vitiligo, or purulent dermatitis .
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The 2022 Spondyloarthritis International Symposium is about to open, we look forward to your participation
Time of Update: 2022-08-16
Integrated therapies in spondyloarthritisleave a message here Spondyloarthritis (SpA) is a chronic inflammatory disease affecting the spine and surrounding joints and some internal organs, and is related to congenital genetic genes and acquired environmental factors .
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A&R: The role of lysine-specific demethylase 1 in integrating osteoclast differentiation and inflammatory bone resorption through hypoxia-inducible factor 1α and E2F1 metabolism
Time of Update: 2022-08-16
This study aimed to assess whether the protein lysine-specific demethylase 1 (LSD1) metabolically integrates inflammatory osteoclastogenesis and bone resorption in inflammatory arthritis states .
This study aimed to assess whether the protein lysine-specific demethylase 1 (LSD1) metabolically integrates inflammatory osteoclastogenesis and bone resorption in inflammatory arthritis states .
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A study of 70,000 Chinese people revealed that eating beans is related to increased uric acid, but eating meat has no effect!
Time of Update: 2022-08-16
. Not only that, the researchers also specifically analyzed the association between each food group in the Deshu diet and hyperuricemia, the results showed: more vegetables, fruits, whole grains, less fat, sugar-sweetened beverages, Soy and dairy products are associated with a reduced risk of hyperuricemia .
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Dermatology: Skin disease worse in patients with psoriatic arthritis than in patients with psoriasis alone?
Time of Update: 2022-08-16
Recently, a systematic review published in Dermatology discussed the relationship between psoriatic skin severity and the presence and development of PsA .
Recently, a systematic review published in Dermatology discussed the relationship between psoriatic skin severity and the presence and development of PsA .
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Rheumatol Ther: Long-Term Study of Secukinumab in Patients with Psoriatic Arthritis or Ankylosing Spondylitis
Time of Update: 2022-08-16
Both PsA and AS are interrelated disorders with various common clinical, genetic, and immune featuresPsoriatic arthritis presents with variability in disease activity and clinical presentation, and is characterized by articular and extra-articular manifestations, including peripheral arthritis, axial involvement, tendinitis, dactylitis, and skin or nail disease .
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Freshly organized!
Time of Update: 2022-08-16
Click on the image to see a larger image and save it Note: The specific usage is listed in a column, and the gray font is for the editor to check the FDA official website information and instructions .
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ARD: IL-12/23 pathway inhibitors ustekinumab or TNFi have comparable persistence and efficacy in patients with psoriatic arthritis
Time of Update: 2022-08-16
Safety was similar in both groups Conclusions : In the real-world PsABio study, after 1 year of treatment, while unadjusted ustekinumab persistence was numerically slightly higher than TNFi , unadjusted efficacy was numerically slightly higher than TNFi ustekinumab , but a propensity-score-adjusted comparison showed comparable overall persistence, efficacy, and safety for ustekinumab and TNFi for both modes of action in PsA .
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How should rheumatoid patients choose biologics?
Time of Update: 2022-08-16
After receiving adalimumab treatment to meet the standard, the disease recurrence rate within 1 year of drug withdrawal is low, and it can significantly and long-term improve the symptoms and signs of all kinds of RA patients, and improve the quality of life of patients .
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A&R: Identification of Mitofusin 1 and complement component 1q subcomponent binding proteins as mitochondrial targets in systemic lupus erythematosus
Time of Update: 2022-08-16
Leave a comment here Purpose : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes .
Leave a comment here Purpose : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes .
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A&R: Epigenetic regulation of nutrient transporters in fibroblast-like synoviocytes in rheumatoid arthritis
Time of Update: 2022-08-16
Purpose : Since previous studies have demonstrated altered metabolism in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) , this study aimed to identify genome-wide chromatin in genes associated with nutrient transporters and whether changes in DNA status help identify metabolic pathways in activated RA FLS .
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A&R: Rheumatoid factor and anti-modified protein antibody reactivity converge on IgG epitopes
Time of Update: 2022-08-16
Methods Methods : Using sera from patients with RA , systemic lupus erythematosus, Sjogren's disease (SjD), or spondyloarthropathy, IgG versus native, citrulline- and homocitrulline-containing IgG constant region linear epitopes were assessed by peptide array Binding to highly bound epitopes was further assessed by enzyme-linked immunosorbent assay ( ELISA ) .
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More than lupus erythematosus!
Time of Update: 2022-08-16
2020 "China Systemic Lupus Erythematosus Guidelines": Long-term use of hydroxychloroquine as a basic treatment drug is recommended for patients without contraindications .
In a retrospective study in Europe, adding HCQ to routine care in pregnant women with lupus erythematosus significantly improved refractory obstetric APS effectively reduce the risk of thrombosis .
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Prof. Zhang Wei: Interpretation of systemic lupus erythematosus classification criteria
Time of Update: 2022-08-16
outline: What progress in the diagnosis and treatment of systemic lupus erythematosus (SLE) at the 2021 ACR Congress deserves the attention of clinicians?
What progress in the diagnosis and treatment of systemic lupus erythematosus (SLE) at the 2021 ACR Congress deserves the attention of clinicians?
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Professor Wang Yanyan: What should I do if methotrexate is not effective for rheumatoid patients?
Time of Update: 2022-08-16
01What are the challenges for rheumatologists in the context of the new crown epidemic?The patient was unable to return to the clinic in time due to the epidemicThe patient was unable to return to the clinic in time due to the epidemicThe vast majority of rheumatology patients are chronic diseases that require regular follow-up to adjust the medication regimen .
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Case sharing: What should I do if I encounter atypical gout?
Time of Update: 2022-08-16
Chen Jian Attending Physician, Master of Medicine Introduction: Attending physician in the Department of Rheumatology and Immunology, The Third Affiliated Hospital of Guangzhou Medical University, graduated from Guangdong Provincial People's Hospital of Southern Medical University with a master's degree .
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Professor Li Jing: Why is methotrexate so classic & how is methotrexate safe to use?
Time of Update: 2022-08-16
Methotrexate, a classic antirheumatic drug in rheumatology, is also the gold standard for rheumatoid arthritis treatment research . Why does methotrexate have such a "state of the rivers and lakes"?Me
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Invest Dermatol: The golden age of statin therapy for psoriasis is coming?
Time of Update: 2022-08-16
Given the accumulation of evidence that psoriasis accelerates vascular disease, in 2018, the American College of Cardiology/American Heart Association issued landmark guidelines identifying psoriasis as an increased cardiovascular risk factor and recommending that in patients with psoriasis Early statin use (ie, in patients with a 5% 10-year risk of atherosclerotic disease) .
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ARD: What is the success rate of discontinuation of glucocorticoids after initial therapy in RA patients?
Time of Update: 2022-08-16
. Methods : A systematic literature search was performed to identify observational cohorts and clinical trials of RA patients receiving initial GC bridging therapy (defined as discontinuation of GC therapy within 1 year) .
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ARD: Development and Initial Validation of the Sjogren's Response Assessment Tool (STAR): A Consensus Composite Score for Evaluating Treatment Effects in Primary Sjögren's Syndrome
Time of Update: 2022-08-16
Method :methodTo develop STAR , the NECESSITY (New Clinical Endpoint in Primary Sjögren's Syndrome: Interventional Trial Based on Patient Stratification) consortium used a data-driven approach based on nine randomised controlled trials (RCTs) and involving 78 specialists and 20 patients consensus technology .
