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A&R: Identification of Mitofusin 1 and complement component 1q subcomponent binding proteins as mitochondrial targets in systemic lupus erythematosus
Time of Update: 2022-08-16
Leave a comment here Purpose : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes .
Leave a comment here Purpose : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membranes .
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Daily broadcast of routine blood tests for rheumatoid arthritis
Time of Update: 2022-08-16
Anemia of chronic disease, increased platelet counts, and elevated acute-phase reactants such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are common in patients with active RA Anemia of chronic disease, increased platelet counts, and elevated acute-phase reactants such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are common in patients with active RA .
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Professor Li Jing: Why is methotrexate so classic & how is methotrexate safe to use?
Time of Update: 2022-08-16
Methotrexate, a classic antirheumatic drug in rheumatology, is also the gold standard for rheumatoid arthritis treatment research . Why does methotrexate have such a "state of the rivers and lakes"?Me
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The 2022 Spondyloarthritis International Symposium is about to open, we look forward to your participation
Time of Update: 2022-08-16
Integrated therapies in spondyloarthritisleave a message here Spondyloarthritis (SpA) is a chronic inflammatory disease affecting the spine and surrounding joints and some internal organs, and is related to congenital genetic genes and acquired environmental factors .
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A&R: Endothelial Activation Antibodies in COVID-19 Patients
Time of Update: 2022-08-16
42094 leave a comment here OBJECTIVE : Endothelial dysfunction is associated with widespread thrombo-inflammatory complications of COVID-19 , with venous thromboembolism being particularly pronounced ( 10-35% ) in severe COVID-19 , and autopsy specimen findings suggest it affects up to 60% of patients , and is associated with COVID-19- related mortality .
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More than lupus erythematosus!
Time of Update: 2022-08-16
2020 "China Systemic Lupus Erythematosus Guidelines": Long-term use of hydroxychloroquine as a basic treatment drug is recommended for patients without contraindications .
In a retrospective study in Europe, adding HCQ to routine care in pregnant women with lupus erythematosus significantly improved refractory obstetric APS effectively reduce the risk of thrombosis .
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A&R: Epigenetic regulation of nutrient transporters in fibroblast-like synoviocytes in rheumatoid arthritis
Time of Update: 2022-08-16
Purpose : Since previous studies have demonstrated altered metabolism in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) , this study aimed to identify genome-wide chromatin in genes associated with nutrient transporters and whether changes in DNA status help identify metabolic pathways in activated RA FLS .
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A&R: Haploinsufficiency of PSMD12 leads to proteasome dysfunction and subclinical autoinflammation
Time of Update: 2022-08-16
42070 Leave a comment here OBJECTIVE : Proteasome-associated autoinflammatory syndrome (PRAAS) is clinically characterized by recurrent fever, neutrophilic skin disease, lipodystrophy, joint contractures, and developmental delay .
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Non-steroidal anti-inflammatory drugs, rational use 7 remember
Time of Update: 2022-08-16
The summary of its medication instructions is now shared with the majority of physicians and pharmacists for reference: Non-steroidal anti-inflammatory drugs (NSAIDs) are non-hormonal anti-inflammatory and analgesic drugs that play an important role in pain treatment .
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A&R: Rheumatoid factor and anti-modified protein antibody reactivity converge on IgG epitopes
Time of Update: 2022-08-16
Methods Methods : Using sera from patients with RA , systemic lupus erythematosus, Sjogren's disease (SjD), or spondyloarthropathy, IgG versus native, citrulline- and homocitrulline-containing IgG constant region linear epitopes were assessed by peptide array Binding to highly bound epitopes was further assessed by enzyme-linked immunosorbent assay ( ELISA ) .
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A&R: The role of lysine-specific demethylase 1 in integrating osteoclast differentiation and inflammatory bone resorption through hypoxia-inducible factor 1α and E2F1 metabolism
Time of Update: 2022-08-16
This study aimed to assess whether the protein lysine-specific demethylase 1 (LSD1) metabolically integrates inflammatory osteoclastogenesis and bone resorption in inflammatory arthritis states .
This study aimed to assess whether the protein lysine-specific demethylase 1 (LSD1) metabolically integrates inflammatory osteoclastogenesis and bone resorption in inflammatory arthritis states .
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Exciting!
Time of Update: 2022-08-16
. This year 's publication of the document " Expert Consensus on Allogeneic Mesenchymal Stem Cell Therapy for Systemic Lupus Erythematosus " means that lupus treatment has a new method for clinical reference.
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Dermatology: Skin disease worse in patients with psoriatic arthritis than in patients with psoriasis alone?
Time of Update: 2022-08-16
Recently, a systematic review published in Dermatology discussed the relationship between psoriatic skin severity and the presence and development of PsA .
Recently, a systematic review published in Dermatology discussed the relationship between psoriatic skin severity and the presence and development of PsA .
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ARD: Good long-term benefits of low-dose corticosteroids in rheumatoid arthritis patients over 65 years
Time of Update: 2022-08-16
. Methods : The GLORIA (low-dose glucocorticoid in rheumatoid arthritis) practical double-blind randomized trial compared 2 years of prednisolone ( 5 mg / day) with placebo in patients over 65 years of age with active RA .
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A&R: Nintedanib slows lung function decline in patients with systemic sclerosis-related interstitial lung disease (ILD)
Time of Update: 2022-08-16
CONCLUSIONS: In the INBUILD trial, nintedanib slowed the rate of FVC decline in patients with progressive fibrotic autoimmune disease-related ILD , and adverse events were manageable in most patients .
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Freshly organized!
Time of Update: 2022-08-16
Click on the image to see a larger image and save it Note: The specific usage is listed in a column, and the gray font is for the editor to check the FDA official website information and instructions .
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Invest Dermatol: The golden age of statin therapy for psoriasis is coming?
Time of Update: 2022-08-16
Given the accumulation of evidence that psoriasis accelerates vascular disease, in 2018, the American College of Cardiology/American Heart Association issued landmark guidelines identifying psoriasis as an increased cardiovascular risk factor and recommending that in patients with psoriasis Early statin use (ie, in patients with a 5% 10-year risk of atherosclerotic disease) .
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Professor Wang Yanyan: What should I do if methotrexate is not effective for rheumatoid patients?
Time of Update: 2022-08-16
01What are the challenges for rheumatologists in the context of the new crown epidemic?The patient was unable to return to the clinic in time due to the epidemicThe patient was unable to return to the clinic in time due to the epidemicThe vast majority of rheumatology patients are chronic diseases that require regular follow-up to adjust the medication regimen .
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Prof. Zhang Wei: Interpretation of systemic lupus erythematosus classification criteria
Time of Update: 2022-08-16
outline: What progress in the diagnosis and treatment of systemic lupus erythematosus (SLE) at the 2021 ACR Congress deserves the attention of clinicians?
What progress in the diagnosis and treatment of systemic lupus erythematosus (SLE) at the 2021 ACR Congress deserves the attention of clinicians?
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ARD: What is the success rate of discontinuation of glucocorticoids after initial therapy in RA patients?
Time of Update: 2022-08-16
. Methods : A systematic literature search was performed to identify observational cohorts and clinical trials of RA patients receiving initial GC bridging therapy (defined as discontinuation of GC therapy within 1 year) .