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Background : Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) , but the balance of benefits and harms remains uncle.
Background Background : Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) , but the balance of benefits and harms remains uncle.
Methods : The GLORIA (low-dose glucocorticoid in rheumatoid arthritis) practical double-blind randomized trial compared 2 years of prednisolone ( 5 mg / day) with placebo in patients over 65 years of age with active R.
Methods The GLORIA (low-dose glucocorticoid in rheumatoid arthritis) practical double-blind randomized trial compared 2 years of prednisolone ( 5 mg / day) with placebo in patients over 65 years of age with active R.
RESULTS: A total of 451 patients with established RA with an average of 1 comorbidities, a mean age of 72 years, a disease duration of 11 years, and a DAS28 of 5 were randomly assigne.
CONCLUSIONS: Additional low-dose prednisolone has long-term beneficial effects in older patients with established RA , with increased benefit in most patients with non-severe AEs ; this suggests a good balance of benefits and harm.
Boers M, Hartman L, Opris-Belinski D For the GLORIA Trial consortium , et a.
Boers M, Hartman L, Opris-Belinski D For the GLORIA Trial consortium , et a.
Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA tri.
Annals of the Rheumatic Diseases2022; 81: 925-93 , et al Annals of the Rheumatic Diseases81: Leave a comment here