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A&R: Identification of Mitofusin 1 and complement component 1q subcomponent binding proteins as mitochondrial targets in systemic lupus erythematosus

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Purpose : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membran.

Objective Objective : Mitochondria exhibit various bacterial characteristics, such as a double-stranded genome with hypomethylated CpG islands, formylated proteins, and cardiolipin-containing membran.

Methods : Using shotgun proteomic analysis, the research team identified 1345 proteins, 431 of which were associated with the mitochondrial proteo.

Methods Using shotgun proteomic analysis, the research team identified 1,345 proteins, 431 of which were associated with the mitochondrial proteo.

Results This study identified significantly elevated IgG antibodies to complement component C1q -binding protein in SLE patients ( P=049 ) and was also associated with lupus anticoagulant positivity ( P=049 .

Conclusions This study describes the mitochondrial pool targeted by AMA in the SLE settin.

Source: Becker YLC, Gagné JP, Julien AS, Lévesque T, Allaeys I, Gougeard N, Rubio V, Boisvert FM, Jean D, Wagner E, Poirier GG, Fortin PR, Boilard.
Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematos.
Arthritis Rheumat.
2022 Jul;74(7):1193-120 doi: 11002/a.
4208 Epub 2022 JunPMID: 3512884 Leave a comment here

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