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PNAS: Scientists are expected to use the blistering oral disease virus to reveal the molecular mechanisms by which SARS-CoV-2 blocks the immune response of host bodies
Time of Update: 2020-11-29
Ren said that while SARS-CoV-2 is a completely new virus that the world is working on, it uses a strategy similar to VSV to target the same host factors, which may give researchers a deeper understanding of the virus, and after years of research on influenza A viruses and VSVsV, finding such small differences at cellular levels may give scientists a more comprehensive understanding of the disease epidemic caused by COVID-19.
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Science Sub-Journal: Total survival rate up to 80%! CRIS...
Time of Update: 2020-11-29
studies have shown that a single intra-brain injection of CRISPR LNP (sgPLK1-cLNP) in invasive in-place glioblastoma in mice can increase the gene editing rate in the body by about 70%, significantly reduce tumor growth, extend the medium survival by about 50%, and increase the overall survival rate to 30% (figure H below).
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Sci Adv: Diabetics are more susceptible to glucobacteria
Time of Update: 2020-11-29
recent study, Richardson, Thurlow and other team members experimented with diabetic and non-diabetic mice and staphylococcus strains with or without additional transport proteins.
in diabetic mice, Staphylococcus acobacteria strains with four glucose transport proteins rapidly form biofilms and activate molecular pathways that make them more toxic.
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The first new treatment in 60 years! GSK returning bile acid transporter inhibitor linerixibat treats bile depressive itching with remarkable efficacy!
Time of Update: 2020-11-29
GSK has plans to launch Phase 3 clinical studies in 2021, and linerixibat has the potential to become the first new treatment for PBC bile itching in 60 years.
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Nat Cancer: There's hope for treating many types of cancer! A new type of immunotherapy has entered early clinical trials!
Time of Update: 2020-11-29
In the study, researchers revealed why previous attempts by scientists have failed, and they have developed a special antibody with no excess activity that produces a powerful anti-tumor response in mouse bodies, and are currently conducting clinical trials to test its potential and effectiveness against multiple types of cancer.
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Mol Cell: Reveals the molecular mechanisms by which cells collect and discard damaged proteins
Time of Update: 2020-11-29
16, 2020 // -- In a recent study published in the international journal Molecular Cell, scientists from the University of Massachusetts, Amster, and others revealed the molecular mechanisms of UCH37 e
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Cell Rep: Scientists have found potential targets that could help develop new treatments for endometriosis
Time of Update: 2020-11-29
November 16, 2020 // -- In a recent study published in the international journal Cell Reports, scientists from Michigan State University and others identified a potential genetic target, or promising
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Nat Med: Scientists have successfully used macro genome sequencing technology to quickly identify pathogens in human body fluids
Time of Update: 2020-11-29
16, 2020 // -- In a recent study published in the international journal Nature Medicine, scientists from the University of California and others found that macrogenome sequencing techniques could be u
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TCR therapy welcomed the first positive Phase 3 results and significantly improved the overall survival rate
Time of Update: 2020-11-29
Today, Immunocore announced that its innovative T-cell-to-patient (TCR) therapy achieved positive mid-term results in Phase 3 clinical trials, significantly increasing the total survival rate (OS) of cancer patients treated.
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Nat Med: How immune memory is formed during the recovery phase of new coronavirus infection
Time of Update: 2020-11-28
In this way, we believe that most people who survive SARS-CoV-2 infection have a protective effect on re-infection," explains Dr. Hoffman of the Second Department of Medicine at Freiburg University Medical Center.
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eLife interpretation! Oxidants may help slow down the aging process in cells!
Time of Update: 2020-11-28
Photo Source: Mikael Molin/Chalmers University of Technology In fact, researchers are now taking another step forward in understanding how oxidants really slow down the molecular mechanisms behind the body's aging process, which may help them with new research, such as finding drugs that stimulate antioxidant proteins or detecting whether other drugs that boost the body's oxidants can slow age-related diseases.
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PNAS: Research reveals new mechanisms for promoting tissue repair
Time of Update: 2020-11-28
"This study provides a basic understanding of how macroph.com ages regulate their response to pathogens to provide an effective but controlled inflammatory response and avoid damage to host tissue," said lead author Ricardo Irizarry-Caro of the Cincinnati Department of Child Immunobiology and senior author Dr. Chandrashekhar Pasare.
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Science sub-journal interpretation! Does air pollution really make the COVID-19 epidemic even more deadly?
Time of Update: 2020-11-28
Air pollution and COVID-19 mortality in The United States: Strengths and lys of an ecological regression analysis, Science Advances 04 Nov 2020, doi:10.1126/sciadv.abd4049(2) Jeremy Jackson, Kip Hodges.
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Ebiomedicine: New research helps treat inflammation
Time of Update: 2020-11-28
NOVEMBER 19, 2020 // -- In a recent study, a team of researchers from WEHI found a new compound that blocks key inflammatory pathways, potentially paving the way for new treatments for a variety of diseases, including COVID-19.
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Is honey really good for your body's health?
Time of Update: 2020-11-28
Photo Source: CC0 Public Domain A tablespoon of honey contains 64 calories, contains no fiber, few vitamins, and has less protein; although daily consumption of honey is not ideal, researchers have now found that honey has some special medicinal properties, and studies have shown that honey may be a good choice for treating a child's nighttime cough (although it is not considered safe for children under one year of age).
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Structure: Crystallological studies have revealed that HCV drugs can help treat COVID-19
Time of Update: 2020-11-28
November 17, 2020 // -- A recent experiment led by researchers at the U.S. Department of Energy's Oak Ridge National Laboratory has determined that several hepatitis C drugs can inhibit the main protease of SARS-CoV-2, which is critical to the toxic reproduction of new coronary diseases.
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The first condensate-collecting disease (CAD) hemolytic therapy drug! Sanofi supplement C1s inhibitor sutimlimab was rejected by the FDA!
Time of Update: 2020-11-28
November 18, 2020 // -- Sanofi recently announced that the U.S. Food and Drug Administration (FDA) has issued a full response letter (CRL) to Suttimlimab's Biological Products Licensing Application (BLA), a monoclonal antibody used to treat hemolysis in adult patients with primary coagulation disease (CAD).
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New medicine for rare diseases! C3 inhibitor pegcetacoplan received FDA priority review: Phase 3 efficacy beats heavyweight C5 inhibitor Soliris
Time of Update: 2020-11-28
Recently, the company announced that the U.S. Food and Drug Administration (FDA) has accepted and granted priority review to a new drug application (NDA) for Pgcetacoplan (APL-2), a drug used to treat cystic sleep hemoglobinuria (PNH), which has been shown in clinical trials to raise PNH standards and hopefully redefine PNH treatment.
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STM: The intrinsic mechanism of immune rejection of stem cell transplantation
Time of Update: 2020-11-28
November 19, 2020 // -- In the treatment of leukemia, stem cell transplants after chemotherapy and radiotherapy often cause severe adverse inflammatory reactions, especially in the skin or intestines, as these so-called "barrier" organs are more susceptible.
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JCI interpretation! In-depth understanding of the pathogenesis of rare diabetes may help clarify the mysteries of insulin production in the body!
Time of Update: 2020-11-28
18, 2020 // -- In a recent study published in the international journal Journal of Clinical Investigation, scientists from the University of Exeter and others revealed the molecular mechanisms of insu