PNAS: Scientists are expected to use the blistering oral disease virus to reveal the molecular mechanisms by which SARS-CoV-2 blocks the immune response of host bodies

November 16, 2020 // -- In a recent study published in the international journal Proceedings of the National Academy of Sciences, scientists from Vanderburg University and other institutions revealed the molecular mechanisms of SARS-CoV-2 targeting and affecting its host factor protein.
researcher Yi Ren said: 'We looked at the basic molecular mechanisms of protein expression in cells and also revealed how different viruses target and block the function of key immune factors in cellular machines; Virus) for research, VSV is a rabies-like virus that mainly affects cattle, horses, and pigs, which is particularly sensitive to interferon, a special signaling protein produced by host cells when they perceive the virus, which is produced to induce nearby cells to enhance their antiviral defense mechanisms.
photo Source: NIAID After reviewing a study of coronavirus-related studies published in early 2020, researcher Ren says the protein of SARS-CoV-2 virus may have some similar characteristics to VSV, which inhibits interferon, otherwise interferon In the paper, the researchers revealed that the mechanism by which protein expression is blocked in VSV may have helped conduct COVID-related studies, and that the researchers were able to detect direct interactions between the host factors they studied and the specific proteins of the SARS-CoV-2 virus.
's findings suggest that SARS-CoV-2 can use a strategy similar to VSV to target the same susceptible proteins that act as host factors, but the difference is that SARS-CoV-2 has a mechanism that blocks proteins from sharing genetic information with the host cell nucleus, which can promote suppression of the body's immune system, which may come as a big surprise to researchers who spend a lot of time in the lab studying VSV.
Ren said that while SARS-CoV-2 is a completely new virus that the world is working on, it uses a strategy similar to VSV to target the same host factors, which may give researchers a deeper understanding of the virus, and after years of research on influenza A viruses and VSVsV, finding such small differences at cellular levels may give scientists a more comprehensive understanding of the disease epidemic caused by COVID-19. Later
researchers will continue to study the structural properties of virus-host interactions to discover the secrets, and they will reveal at the atomic level how viral proteins target the host's cellular machines and their consequences, a key step in designing new therapies to promote a suitable immune response from host bodies.
'We have a very strong team of structural biologists at Vanderburg University who share our findings and amazing resources, and many scientists are making their due contributions to COVID-19-related research, and we have moved quickly from the study of influenza A virus and VSV to the study of SARS-CoV-2 virus, believing that through further research, we will make a major breakthrough in the field of SARS-CoV-2 virus research,' said Ren, a researcher at Vanderburg University.
original source: Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, et al. SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.2016650117