Sci Adv: Diabetics are more susceptible to glucobacteria

November 16, 2020 // -- A new study by scientists at the University of Pittsburgh School of Medicine shows that people with diabetes appear to be more susceptible to Staphylococcus ausptional infection.
results were published recently in the journal Science Advance.
researchers report that Staphylococcus acobacteria, a bacteria that is often resistant to antibiotics, thrives in diabetics rich in glucose, activating some of the most toxic functions.
, a lack of insulin prevents the immune system from responding to infections.
, associate professor of microbiology and molecular genetics at www.pixabay.com), said: "This explains why it is really necessary to actively treat wounds in people with diabetes.
the immune system needs help to identify and remove infections.
as much as one-third of people with diabetes develop diabetic foot ulcers, the most common cause of foot infections and amputations, according to the American Diabetes Association.
Staphylococcus acuity are most commonly associated with these types of invasive infections, especially in people with poor diabetes control.
the past three decades, the incidence of Staphylococcus acolyte infection and diabetes has increased simultaneously.
recent study, Richardson, Thurlow and other team members experimented with diabetic and non-diabetic mice and staphylococcus strains with or without additional transport proteins.
in diabetic mice, Staphylococcus acobacteria strains with four glucose transport proteins rapidly form biofilms and activate molecular pathways that make them more toxic.
, those with diabetes had a particularly slow immune response, leading to uncontrolled infections and severe diabetic ulcers.
in non-diabetic mice, the immune system was able to control and fight infection.
, when diabetic mice were given blood sugar-lowering drugs, their levels of infection were significantly reduced, becoming almost the same as in normal mice.
() Source: Scientists discover secret to superbug's virulence in diabetics Source: L.R. Thurlow el al., "Lack of the physic immunity in diabetic skin skins promotes Staphylococcus aureus virulence," Advances (2020). advances.sciencemag.org/lookup ... 1126 / sciadv.abc5569