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FASEB J: A common oral bacteria may promote metabolic syndrome by altering the body's gut microbiome
Time of Update: 2020-12-28
Photo Source: Dr. Kazuki Watanabe, lead author of the Tokyo Medical and Dental University article, said metabolic syndrome is increasingly a widespread health problem in people in developed countries, and our goal is to investigate how periodontial bacterial infections cause changes in skeletal muscle metabolism that in turn induce metabolic syndrome.
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The Lancet: Scientists Release Results of Human Phase 3 Interim Clinical Trials of COVID-19 Vaccine: ChAdOx1 Vaccine May Show Acceptable Safety and Efficacy!
Time of Update: 2020-12-28
December 11, 2020 // -- A recent article published in the international magazine The Lancet entitled "Safety and efficacy of the chAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: anterim analysis
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Science Sub-Journal: A new longitudinal study documented COVID-19 antibody responses five months after symptoms appeared
Time of Update: 2020-12-28
11, 2020 /----- In a new study, researchers from Stanford University and other research institutions in the United States conducted a five-month longitudinal analysis of 254 patients with COVID-19 showing varying severity from asymptomatic to fatal diseases, showing that IGA and IgM antibodies for SARS-CoV-2 coronavirus disappeared rapidly during recovery.
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AJKD: New therapy helps protect the kidneys of diabetics
Time of Update: 2020-12-28
researchers at the University of Limerick School of Medicine and Limerick University Hospital, in collaboration with researchers at the University of California, San Diego, and AstraZeneta, found that a combination of Verinurad and Febuxostat reduced proteinuria in the urine of type 2 patients by 39.4 percent compared to placebo, and treated diabetes after 12 weeks.
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Nat Commun: New potential anti-cancer therapies may effectively enhance the immune response of host bodies to target cancer treatments
Time of Update: 2020-12-28
11, 2020 // -- In a recent study published in the international journal Nature Communications, scientists from Siddasenai Medical Center and others developed a new approach to cancer therapy by studyi
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Sci Adv: A drug used to treat rare enzyme deficiency, benzoic acid, or to treat human herpes simplex virus infection
Time of Update: 2020-12-28
researchers say that when used with axiovir, a commonly used HSV-1 therapy, the antiviral activity of a drug called PBA (PBA, phenylbutyrate) may perform better; researcher Deepak Shukla says there are very few drugs to treat herpes simplex viruses, so when new drugs appear, especially those that reduce side effects, it may be a study that scientists are interested in.
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Breakthrough drug for bile siltation! Powerful back-to-bowel bile acid transporter inhibitor odevixibat applied for listing in the United States and the European Union!
Time of Update: 2020-12-28
results showed that the study reached the main endpoint of regulatory requirements in the United States and the European Union: odevixibat significantly reduced bile acid response (SBA, p-0.003), significantly improved skin itching (p-0.004), and had a single-digit diarrhea rate compared to placebos.
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First FcRH5xCD3 dual-specific antibodies! Roche cevostamab treatment of high-risk multiple myeloma: total remission rate of 53%!
Time of Update: 2020-12-28
December 11, 2020 // -- Roche recently released for the first time clinical safety and ability data for the third dual-specific antibody cevostamab (BFCR4350A) in the malignant hematology pipeline.
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ACS Sensors: Scientists have developed a new way to effectively assess vaccine safety
Time of Update: 2020-12-28
December 11, 2020 // -- In a recent study published in the international journal ACS Sensors entitled "iGIST-A Kinetic Bioassay for PertusSis Toxin On Its Effect on Analytics GPCR Signaling", scientists from the University of Turku and others developed a new method for evaluating vaccine safety, which could significantly reduce the use and number of animal trials in vaccine industry.
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Nature: Heavy! Scientists have successfully mapped the metastasis of human cancer cell lines!
Time of Update: 2020-12-28
December 11, 2020 // -- In a recent study published in the international journal Nature entitled "A metastasis map of human cancer cell lines", scientists from the Broad Institute and other institutio
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JPR: Heavy! Scientists hope to treat breast cancer with the circadian rhythm hormone melatonin!
Time of Update: 2020-12-28
Looking for targeted genes to identify molecular markers that could serve as guidelines for cancer therapy, the researchers first conducted a comprehensive analysis of how melatonin regulates the expression of microRNA molecules in a variety of regulated, including breast, head and neck, liver, stomach, prostate, central nervous system and colorectal cancers.
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PNAS: TRNA fragments are involved in the post-stroke immune response
Time of Update: 2020-12-28
, explains Lobentanzer: "TRNA fragments, which until now have been thought of as transport RNA fragments, have recently been shown to have biological functions; (Photo: www.pixabay.com) The project was initiated and led by Hermona Soreq (Hebrew University of Israel) and Andreas Meisel (Berlin Charté), who jointly studied the contributions of small RNA regulators that signal choline in blood cells in stroke patients funded by the Einstein Foundation.
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Two Cell papers reveal that powerful human-medium antibodies are expected to fight attacks from eastern horse encephalitis, Hendra and Nipah viruses
Time of Update: 2020-12-28
results were published in the December 10, 2020 issue of cell, under the title "Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Protein Binding." from Cell, 2020, doi:10.1016/j.cell.2020.11.023.
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Innovative drug for optic neurospinal corditis spectrum disorder (NMOSD)! Chinese and foreign drug IL-6R single anti-Enspryng approved in Taiwan, China!
Time of Update: 2020-12-28
data from two randomized controlled Phase III studies (SakuraStar, SAkuraSky) confirmed that enspryng was treated as a monotherapy and baseline in adult patients with AQP4 antibody-positive NMOSD Immunosuppressant (IST, commonly used to manage relapse-related NMOSD symptoms) combined treatment has strong and long-lasting efficacy and good safety: Enspryng significantly reduces the risk of recurrence compared to placebos and lasts up to 96 weeks.
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Cell paper interpretation! The new findings upend traditional perceptions of killer T-cells and help develop CAR-T cells that better target solid tumors
Time of Update: 2020-12-28
The discovery may help solve many of the challenges of immunology, including medical mysteries such as why recently developed cancer treatments using genetically modified lethal T-cells do not work well against solid tumors, and why HIV, the AIDS-related virus that is thought to be very vulnerable to killer T-cells, seems to be able to escape these immune cells indefinitely by hiding out of the blood.
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Two Science sub-journals have shown that IgA antibodies dominate early response to SARS-CoV-2 coronavirus and are more effective in mediating the virus
Time of Update: 2020-12-28
results were published online December 7, 2020 in the journal Translational Medicine under the title "IgA dominates the early neutralizing antibody response to SARS-CoV-2".
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Sci Immunol: Scientists are expected to successfully manipulate bone marrow stem cells to convert them into congenital lymphocytes and natural killer cells
Time of Update: 2020-12-28
12, 2020 /PRY/ -- Scientists from institutions such as Colorado Children's Hospital successfully manipulated bone marrow stem cells to transform them into congenital lymphocytes and natural killer cel
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Nat Commun: Scientists have developed a special "framework" that may help determine when cancer mutates
Time of Update: 2020-12-28
11, 2020 // -- In a recent study published in the international journal Nature Communications, scientists from the University of California and others have developed a special framework to help determine which combination of tools is best suited to pinpoint the exact time of DNA mutations in the cancer genome.
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Plos One: High body temperature affects the recovery of rheumatoid arthritis patients
Time of Update: 2020-12-28
study, published in PLOSONE and conducted by the University of Malta and the University of Staffordshire, compared thermal imaging patterns during remission in patients with rheumatoid arthritis (RA) with healthy individuals.
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The results of two clinical trials in NEJM show that new gene therapy may be available to treat sickle cell anemia
Time of Update: 2020-12-27
the first study, researchers used crispr-Cas9 gene editing systems to enhance fetal hemoglobin production in the body of patients with sickle cell anemia.
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia, New England Journal of Medicine (2020).
