FASEB J: A common oral bacteria may promote metabolic syndrome by altering the body's gut microbiome

December 11, 2020 // -- Periodontology is known to be an important risk factor for the development of metabolic syndrome, a group of diseases that increase the risk of heart disease and diabetes in the body, according to a study published in the international journal THE FASEB Journal. Scientists from Tokyo Medical and Dental University and other institutions have found that an infection of periodontogenic bacteria, the gum monocytobacteria, may promote abnormal skeletal metabolism by altering the composition of the body's gut microbiome, which may be a precursor to metabolic syndrome.
periodont bacteria have long been thought to cause inflammation in the mouth, while also systematically increasing levels of inflammatory media.
, persistent infections of periodont bacteria may increase the body weight of the patient and lead to increased insulin tolerance (a sign of type 2 diabetes).
function of insulin is to help transport blood sugar through the tissues, the most important of which is the skeletal muscle, a quarter of all glucosaccharine in the body is stored in the skeletal muscle. insulin tolerance plays a key role in the development of metabolic syndrome, a group of diseases that include obesity, lipid metabolic changes, high blood pressure, high blood sugar and systemic inflammation, and while skeletal muscles play a key role in helping to lower blood sugar levels in the body, researchers do not yet know the direct link between periodontical bacterial infections and skeletal muscle metabolism,
researchers said.
Photo Source: Dr. Kazuki Watanabe, lead author of the Tokyo Medical and Dental University article, said metabolic syndrome is increasingly a widespread health problem in people in developed countries, and our goal is to investigate how periodontial bacterial infections cause changes in skeletal muscle metabolism that in turn induce metabolic syndrome.
To achieve this goal, the researchers first investigated antibody titers of gum monocytobacteria in the blood of patients with metabolic syndrome and found a positive association between antibody and increased insulin tolerance in patients.
results suggest that people with metabolic syndrome may be more likely to experience infection with the gum monocytobacteria, which induces an immune response to the bacteria in the body.
To understand the molecular mechanisms behind the clinical observations, the researchers then turned to animal models, where they showed increased insulin tolerance and increased fat immersion levels in their skeletal muscles and lower intake of glucose when they were given oral feeding of a high-fat diet containing gum monocytobacteria, a prerequisite for metabolic syndrome.
how can gum monocytobacteria promote systemic inflammation and metabolic syndrome in the host? To answer this question, the researchers focused on the gut microbiome, and found that when mice were injected with gum monocytobacteria, their gut microbiome changed significantly, while reducing the sensitivity of their body's insulin.
Finally, the researchers said that the results of this paper may provide an explanation for clarifying the link between periodontical bacterial gum monocytobacteria infection and body metabolic syndrome and skeletal muscle metabolic abnormalities, and later researchers will continue to conduct more in-depth research to clarify more details of the metabolic syndrome induced by gum monocytobacteria.
original source: Kazuki Watanabe, Sayaka Katagiri, Hirokazu Takahashi, et al. Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota, The FASEB Journal (2020). DOI:10.1096/fj.202001158R。