ACS Sensors: Scientists have developed a new way to effectively assess vaccine safety

December 11, 2020 // -- In a recent study published in the international journal ACS Sensors entitled "iGIST-A Kinetic Bioassay for PertusSis Toxin On Its Effect on Analytics GPCR Signaling", scientists from the University of Turku and others developed a new method for evaluating vaccine safety, which could significantly reduce the use and number of animal trials in vaccine industry.
Photo Source: Unsplash/CC0 Public Domain Vaccine is a safe and effective drug that prevents infectious diseases caused by viruses and bacteria and reduces the spread of pathogens in populations;
In general, vaccines are designed as part of a detoxifying pathogen or pathogen, and the vaccine development industry often uses effective methods to ensure vaccine safety, while developing new ways to ensure vaccine safety.
Pertussis vaccine is a vaccine in Finland's national vaccination programme, which includes the surface structure of Pertussis bacteria and the inactivated form of pertussis toxin produced by bacteria, which can be adsorbed to the surface of cells and penetrate key control systems in cells.
study, researchers developed a new method to ensure the safety of whooping cough toxins in the whooping cough vaccine, a new iGIST method that can help detect how whooping cough toxins disrupt key control systems in host cells.
iGIST, or signal transduction technology that interferes with G-alphai-mediated Signal Transduction.
Finally, researcher Dr. Arto Pulliainen said the iGIST method may be more effective than the methods currently used in the vaccine industry, detecting 100 times lower levels of whooping cough toxins;
() Original source: Valeriy M. Paramonov, Cecilia Sahlgren, Adolfo Rivero-Müller, et al. iGIST-A Kinetic Bioassay for Pertussis Toxin Toxin On Its Effect OnOry GPCR Signaling, ACS Sensors (2020). DOI: 10.1021/acssensors.0c01340。