PNAS: TRNA fragments are involved in the post-stroke immune response

12, 2020 /--- -- Sebastian Lobentanzer of Goethe University has been using biometrics to study small RNA dynamics in a variety of environments.
recently, small RNAs have attracted more and more interest from researchers, mainly because they have a wide range of regulatory functions.
to examine these functions of stroke, Lobentanzer joined Katarzyna Winek of the Hebrew University of Jerusalem to study microRNAs and tRNA fragments from blood samples taken from ischemic stroke patients in Chaité, Berlin.
, explains Lobentanzer: "TRNA fragments, which until now have been thought of as transport RNA fragments, have recently been shown to have biological functions;
(Photo: www.pixabay.com) The project was initiated and led by Hermona Soreq (Hebrew University of Israel) and Andreas Meisel (Berlin Charté), who jointly studied the contributions of small RNA regulators that signal choline in blood cells in stroke patients funded by the Einstein Foundation.
this cooperative effort is the first to demonstrate that monocyte tRNA fragments are involved in the post-stroke immune response.
, it could be a 'protector change', in which tRNA fragments replace microRNAs in single-nuclei," explains Lobentanzer.
bio-information network analysis shows that these two small RNA species have very different functions in the immune response and may therefore play a synergy in regulating the balance of the body.
long term, researchers hope to find treatments that can change these processes.
, many complications can be avoided if the immunity status of each patient after stroke can be determined separately.
(Bioon.com) Source: tRNA fragments are involved in poststroke immune reactions Original source: Katarzyna Winek et al. Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.2013542117。