Nature: Heavy! Scientists have successfully mapped the metastasis of human cancer cell lines!

December 11, 2020 // -- In a recent study published in the international journal Nature entitled "A metastasis map of human cancer cell lines", scientists from the Broad Institute and other institutions in the United States have successfully mapped the metastasis of human cancer cell lines, and the results may help clarify the metastasis mechanisms of cancer and develop new therapies that effectively prevent cancer metastasis and cancer treatment.
photo source.com Most deaths from medium .com cancer can be explained by cancer metastasis, but large-scale cancer metastasis studies have been impractical due to the complex nature of in vivo models.com In the
study, researchers introduced an in vivo bar code strategy that can determine the metastasis potential of human cancer cell lines in mouse foreign transplants on a large scale, confirming the stability, scalability and repeatability of the new method and applying it to 500 cell lines from 21 different types of solid tumors.
the study, researchers developed the first generation of a human cancer cell line metastasis map called MetMap, which reveals organ-specific patterns of cancer metastasis that can be associated with clinical and genomic characteristics.
researchers have confirmed the effectiveness of the MetMap map by investigating the molecular basis of breast cancer that can be transferred to the brain, where cancer brain metastasis is the main cause of death.
Finally, researchers say that breast cancer's ability to transfer to the brain reveals evidence of changes in lipid metabolism in cells, and that disturbances in breast cancer cell lipid metabolism may inhibit cancer brain metastasis, which may reveal a therapeutic strategy that promises to fight the disease, as well as the effectiveness of a map called MetMap that supports cancer metastasis research.
original source: Jin, X., Demere, Z., Nair, K. et al. A metastasis map of human cancer cell lines. Nature 588, 331–336 (2020). doi:10.1038/s41586-020-2969-2。