-
Front Immunol: Innate immune system will aggravate COVID19 symptoms
Time of Update: 2021-03-27
627579Information source: com/news/2021-02-innate-immune-worsens-situation-severe.
627579Information source: com/news/2021-02-innate-immune-worsens-situation-severe.
html">Innate immune system worsens the situation in severe COVID-19Original source: Miklós Lipcsey et al.
html">Innate immune system worsens the situation in severe COVID-19Original source: Miklós Lipcsey et al.
627579Original Source: com/news/2021-02-innate-immune-worsens-situation-severe.
-
Scientists are expected to develop a bacterial therapy to treat human eczema!
Time of Update: 2021-03-27
February 27, 2021 // - Recently, a research report entitled "Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial" was published in the international journal Nature Medicine In, scientists from the University of California and other institutions through research are expected to use bacteria to successfully resist bacteria that accelerate the occurrence of eczema.
-
Professor Zhao Futao: From the outside to the inside, let you have a more comprehensive understanding of Sjogren’s syndrome
Time of Update: 2021-03-27
"Benefiting from a large number of basic research and clinical research data support (Table 2), the 2020 "Primary Sjogren’s Syndrome Guidelines" will include IGU in the recommended list of immunomodulators, and indicated that SS patients with systemic involvement can use it.
-
Professor Chunfu Zheng was invited to publish a review: the latest research progress of DDR protein family in innate immune signaling pathways
Time of Update: 2021-03-27
Recently, Professor Chunfu Zheng was invited to publish a review in International Reviews of Immunology: The Crosstalk between DNA Damage Response Components and DNA-sensing Innate Immune Signaling Pathways.
This article systematically reviews the latest research progress of DDR protein family in innate immune signaling pathways.
-
never expected! Science: The relationship between the intestinal immune system and nutrition is so close!
Time of Update: 2021-03-27
In addition, studies have shown that the remodeling of intestinal epithelial cells occurs during the reaction to certain infections, which may also be the basis for their adaptation to different nutrients.
-
The genes inherent in the body may affect the response to cancer immunotherapy!
Time of Update: 2021-03-27
February 27, 2021 // - Recently, in a research report entitled "Germline genetic contribution to the immune landscape of cancer" published in the international journal Immunity , scientists from the University of California and other institutions said through research , The body’s response to cancer immunotherapy may be affected by the genes carried by our body at birth.
-
Many articles focus on the mysterious connection between microRNA and cancer!
Time of Update: 2021-03-27
html">Oncotarget: A new type of microRNA may target the production of prostaglandin E2 in lung cancer cells, which is expected to help treat lung cancer!bioon.
html">Oncotarget: The new microRNA may target the production of prostaglandin E2 in lung cancer cells, which is expected to help treat lung cancer!doi: 10.
-
What to do if serum IgG4 increases? China's first expert consensus on diagnosis and treatment of IgG4-related diseases is here
Time of Update: 2021-03-27
Recommendation 01 is led by the Department of Rheumatology and Immunology, and the diagnosis, evaluation, treatment and follow-up of IgG4-RD can be completed by multidisciplinary joint IgG4-RD is a systemic disease that can involve multiple organs and tissues throughout the body, including salivary glands, pancreas, lacrimal glands, and orbits Peripheral and orbital tissues, lymph nodes, biliary system, kidney, thyroid, nervous system, retroperitoneum, mesenteric, skin, liver, lung, pleura, mediastinum, pericardium, artery, breast, prostate, etc.
-
Rongchang Bio-Tetacept was approved, the second new drug for systemic lupus erythematosus in 60 years
Time of Update: 2021-03-27
Overexpression of these factors is an important cause of systemic lupus erythematosus (SLE) and other autoimmune diseases related to B lymphocytes.
According to the key clinical research results published by Rongchang Biological, the systemic lupus erythematosus response index (SRI) of the high-dose Taltazep group for 48 weeks was significantly higher than that of the placebo control group (79.
-
JEM | Yang Shuo/Zhou Jiawei/Hu Gang collaborate to reveal the immunological mechanism of inflammasome AIM2 protein-mediated multiple sclerosis
Time of Update: 2021-03-27
Ting research group of the University of North Carolina at Chapel Hill also reported in Nature that AIM2 inhibits the occurrence of multiple sclerosis and other autoimmune diseases through non-inflammatory body function.
-
The body is numb and weak, be careful of rheumatism!
Time of Update: 2021-03-27
Figure 3: Pathological examination of sensory neuron neuropathy The pathological feature of chronic inflammatory demyelinating multiple radiculopathy (CIPD) is chronic demyelination, which is mainly manifested by numbness and weakness of the limbs; electromyography indicates sensory motor neuropathy.
-
Interpretation of Cell papers! Reveal the metabolic mechanism that controls the production of memory T cells
Time of Update: 2021-03-27
Jude Children’s Research Hospital in the United States revealed a previously unknown biological mechanism through which the immune system produces memory T cells to kill bioon.
html">bacterialIn this new study, the authors tried to map the metabolic mechanisms that control how the immune system decides to produce memory T cells.
-
"Nature" Sub-Journal: The mechanism of anti-inflammation when hungry is found! Scientists have found that fasting can inhibit the function of helper T cells and inhibit the production of cytokines. It is effective if you are hungry for a long time | Clinical Discovery
Time of Update: 2021-03-27
This suggests that a longer period of fasting may have a sustained effect on the expression of genes involved in T cell immune regulation.
-
Immunity | Viruses are diverse, immunity is similar
Time of Update: 2021-03-26
These four modules respectively show the similarities and differences of the immune response between severe and mild viral infections, regardless of whether they are infected with common influenza viruses or new coronaviruses.
-
The experimental drug ETC-159 may prevent certain tumors from becoming resistant to therapy by blocking key DNA repair mechanisms!
Time of Update: 2021-03-26
March 26, 2021 // - Recently, a research report entitled "WNT inhibition creates a BRCA-like state in Wnt-addicted cancer" published in the international journal EMBO Molecular Medicine , from Duke-Si
-
Analysis of Nature's Sub-Journal! Demystifying how organisms effectively distinguish the components of RNA and DNA? Or provide new ideas for the development of new antiviral drugs!
Time of Update: 2021-03-26
March 26, 2021 // - Recently, a research report entitled "The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases" was published in the international journal Nature Communications
-
Arthritis Rheumatol: DETECT algorithm can accurately predict the risk of pulmonary hypertension in patients with systemic sclerosis
Time of Update: 2021-03-26
Immune vascular pulmonary hypertension (PAH) is one of the main causes of death in SSc patientsThis study evaluated the prediction accuracy of the DETECT algorithm and the 2015 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines in the SSc cohort that received right heart catheterization (RHC) for pulmonary hypertension (PH) assessment .
-
NEJM: Oral JAK inhibitor abroctinib for moderate to severe atopic dermatitis
Time of Update: 2021-03-26
Recently, researchers compared the JAK1 inhibitor Abroctinib with the interleukin-4 receptor monoclonal antibody Dupilumab for the treatment of atopic dermatitis.
Compared with placebo, abrocitinib can significantly improve the signs and symptoms of moderate to severe atopic dermatitis.
-
Professor Li Zhanguo: Only by doing so can patients with osteoarthritis delay the progression of the disease!
Time of Update: 2021-03-26
Figure 1 The incidence of OA in various provinces in China A multi-center cross-sectional study involving 1066 patients summarized the current status of OA treatment in China.
Patients with joint pain often have indications for the use of disease-modifying osteoarthritis drugs (DMOADs), but currently only 37.
-
Cell: Engineered immune cells can target and inhibit cancer cell metastasis
Time of Update: 2021-03-26
048Furthermore, the authors found that mice treated with GEMys cells had fewer metastatic cancers in the lungs and smaller tumors in the muscles.
048Furthermore, the authors found that mice treated with GEMys cells had fewer metastatic cancers in the lungs and smaller tumors in the muscles.
