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How to treat osteoarthritis, which is common to 200 million people?
Time of Update: 2021-03-25
Osteoarthritis (OA) is a group of heterogeneous diseases characterized by articular cartilage damage and bone hyperplasia at the edges of joints caused by a variety of factors.
Senescent cells can be widely distributed in joint tissues (including articular cartilage, subchondral bone, subpatellar fat pad), secrete SASP-related inflammatory factors, and induce inflammation.
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Eur Arch Otorhinolaryngol: The relationship between nasal cavity patency and changes in orofacial muscle function in patients with asthma and rhinitis
Time of Update: 2021-03-25
Finally, the researchers pointed out that children and adolescents with asthma and rhinitis have reduced nasal patency, but also changes in orofacial muscle function, such as insufficient positioning of the mandible and facial muscle tension when swallowing fluid.
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Paper Interpretation | Nature: How does the human body "remember" the new coronavirus
Time of Update: 2021-03-25
The authors concluded that the continued existence and evolution of memory B cells indicate that when SARS-CoV-2 reinfection occurs, the human body may quickly produce powerful virus-neutralizing antibodies.
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Lupus combined with "this symptom" has a case fatality rate of up to 50%!
Time of Update: 2021-03-25
Table 1 The main test indicators are summarized as follows: In summary, consider the patient's acute abdomen as systemic lupus erythematosus (SLE) mesenteric vasculitis and small bowel obstruction, combined with lupus nephritis and multiple serous effusions.
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A review of the research progress of new antiviral drugs for chronic hepatitis B
Time of Update: 2021-03-25
73 log10 IU/mL, respectively; the combined treatment group and the entecavir single-agent group, the mean values of HBsAg decline were 0.
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JAMA: Intravenous infusion of immunoglobulin + methylprednisolone vs. The effect of simple infusion of immunoglobulin on the course of fever in children with multiple system inflammatory syndrome
Time of Update: 2021-03-25
Many children with MIS-C received empirical treatment based on Kawasaki disease guidelines, using intravenous immunoglobulin (IVIG) alone or in combination with corticosteroids.
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What is the different risk of infection in patients with RA using different biological agents?
Time of Update: 2021-03-25
Risk of Hospitalized Infection and Initiation of Abatacept Versus Tumor Necrosis Factor Inhibitors Among Patients With Rheumatoid Arthritis:A Propensity Score-Matched Cohort Study[J].
Overall infection risk in rheumatoid arthritis during treatment with abatacept, rituximab and tocilizumab;an observational cohort study[J].
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Immunity | Central South University's Lu Ben team reveals the unique role of heparin in sepsis
Time of Update: 2021-03-25
Heparin or a chemically modified form of heparin without anticoagulant function inhibits the alarm protein HMGB1-lipopolysaccharide (LPS) interaction and prevents heparanase from degrading macrophage glycocalyxes.
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Plant Cell | Li Jianfeng's Research Group at Sun Yat-Sen University Reveals New Mechanism of Negative Regulation of Plant Immune
Time of Update: 2021-03-25
On February 2, 2021, Li Jianfeng's research group at Sun Yat-sen University published a research paper entitled The receptor-like cytoplasmic kinase CDG1 negatively regulates Arabidopsis pattern-triggered immunity and is involved in AvrRpm1-induced RIN4 Phosphorylation in The Plant Cell, revealing the The Arabidopsis receptor cytoplasmic kinase CDG1 is a negative regulator of PTI, and AvrRpm1 can induce CDG1 to phosphorylate the Thr166 site of RIN4, resulting in plant ETS.
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Nat Immunol | Gasdermin D-dependent lectin release can trigger inflammation
Time of Update: 2021-03-25
In order to study this problem, the author took the bone marrow-derived macrophages of wild-type and caspase-11-deficient mice as the research object, and took the caspase-11 specific activator Escherichia coli as the stimulant to release the components outside the cell.
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The earliest immune response appears during embryonic development | Nature
Time of Update: 2021-03-25
Here we show that the surface epithelium of zebrafish and mouse embryos, which is the first tissue formed during vertebrate development,performs efficient phagocytic clearance of apoptotic cells through phosphatidylserine-mediated target recognition.
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"Nature" is heavyweight: adjusting immune cell metabolism may reverse brain aging!
Time of Update: 2021-03-25
This study found that immune cells such as macrophages and microglia in the brain and other parts of the body will undergo changes in their metabolic state with aging, converting more glucose into glycogen storage, resulting in their own energy supply something is wrong.
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The New Role of Raf-like Protein Kinases in Rice Immune Response in Mol Plant
Time of Update: 2021-03-25
2-OsMPK6 cascade phosphorylates the Raf-like kinase OsEDR1 and inhibits its The research paper "scaffold function to promote rice disease resistance" reveals the mutual regulation mechanism between a Raf-like protein kinase and mitogen-activated protein kinase (MAPK) signal cascade in rice immune response.
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Shanghai Normal University Meng Xiangzong's research group discovered new plant immunity-inducing small peptides and their receptors
Time of Update: 2021-03-25
Recently, Meng Xiangzong’s research group at Shanghai Normal University published a research paper entitled Perception of the pathogen-induced peptide RGF7 by the receptor-like kinases RGI4 and RGI5 triggers innate immunity in Arabidopsis thaliana on New Phytologist, revealing the secretion of Arabidopsis thaliana.
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How to use "gamma globulin" for these diseases in rheumatology?
Time of Update: 2021-03-25
In the field of rheumatism and dermatology, IVIg has been used to treat diseases such as autoimmune diseases and toxic epidermal necrolysis (Table 1).
The figure below shows the decision to use IVIg to treat severe autoimmune diseases.
The use of IVIg in the treatment of severe autoimmune diseases in dermatology.
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Lilly, GSK, Vir co-develop neutral and antibody combination therapies; FDA approves the first innovative oral lupus nephritis therapy
Time of Update: 2021-03-25
Recently, Amgen announced its research KRAS G12C inhibitor sotorasib (AMG 510), which contains 126 cases The latest results from a pivotal Phase 2 clinical trial in patients with advanced non-small cell lung cancer (NSCLC) with KRAS G12C mutations.
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How do you look at the "Rheumatism" report form?
Time of Update: 2021-03-25
Anti-streptolysin O (ASO), rheumatoid factor (RF), and C-reactive protein (CRP) are common test items in hospitals that combine the "three rheumatism" tests.
In patients with rheumatic diseases, an increase in CRP can be detected in the active stage of the disease, and it can be reduced to normal after the disease is effectively controlled.
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Plant Cell | Highly variable NLR immunoreceptor and prediction of its binding site with effector
Time of Update: 2021-03-25
In conclusion, this article found that the method of using evolutionary tree and Shannon entropy can be used to analyze the evolutionary relationship of NLR within species, and predict whether NLR can directly bind to effectors and the sites where they bind.
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Collect during the epidemic!
Time of Update: 2021-03-25
Conclusion: It is safer for people with low immune function to receive inactivated vaccines; there is no contraindication to vaccination for patients receiving immunosuppressive therapy; there is no clinically significant interaction between vaccines and biological agents for the time being.
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British scientists build a "portrait" of rheumatoid arthritis molecules, further research on chronic diseases
Time of Update: 2021-03-25
Scientists from Queen Mary University of London, University of Cambridge reported their work in this area: Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes.
Lewis et al, Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes,, Cell Reports 28, 2455–2470