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Dean Qi Hai of Tsinghua Medical College re-published Nature, reporting a new mechanism for high-affinity antibody screening
Time of Update: 2021-03-25
The research team speculated that there may be a mechanism that selectively promotes the collision of T cells and high-affinity B cells, thereby increasing the efficiency of antibody affinity maturation.
Based on this, the research team revealed a new mechanism that promotes the maturation of germinal center antibody affinity mediated by the chemokine CCL22.
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The story that must be told between Sjogren's syndrome and B cells
Time of Update: 2021-03-25
The 2020 "Primary Sjogren's Syndrome Diagnosis and Treatment Specifications" pointed out that B-cell targeted therapy can be used for patients with severe and refractory systemic diseases [10].
In September 2020, the National Medical Products Administration approved a new drug clinical trial application for Iramod (IGU) for the treatment of pSS.
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Lupus combined with "this symptom" has a case fatality rate of up to 50%!
Time of Update: 2021-03-25
Table 1 The main test indicators are summarized as follows: In summary, consider the patient's acute abdomen as systemic lupus erythematosus (SLE) mesenteric vasculitis and small bowel obstruction, combined with lupus nephritis and multiple serous effusions.
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Paper Interpretation | Nature: How does the human body "remember" the new coronavirus
Time of Update: 2021-03-25
The authors concluded that the continued existence and evolution of memory B cells indicate that when SARS-CoV-2 reinfection occurs, the human body may quickly produce powerful virus-neutralizing antibodies.
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Lilly, GSK, Vir co-develop neutral and antibody combination therapies; FDA approves the first innovative oral lupus nephritis therapy
Time of Update: 2021-03-25
Recently, Amgen announced its research KRAS G12C inhibitor sotorasib (AMG 510), which contains 126 cases The latest results from a pivotal Phase 2 clinical trial in patients with advanced non-small cell lung cancer (NSCLC) with KRAS G12C mutations.
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Immunity | Central South University's Lu Ben team reveals the unique role of heparin in sepsis
Time of Update: 2021-03-25
Heparin or a chemically modified form of heparin without anticoagulant function inhibits the alarm protein HMGB1-lipopolysaccharide (LPS) interaction and prevents heparanase from degrading macrophage glycocalyxes.
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How do you look at the "Rheumatism" report form?
Time of Update: 2021-03-25
Anti-streptolysin O (ASO), rheumatoid factor (RF), and C-reactive protein (CRP) are common test items in hospitals that combine the "three rheumatism" tests.
In patients with rheumatic diseases, an increase in CRP can be detected in the active stage of the disease, and it can be reduced to normal after the disease is effectively controlled.
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The earliest immune response appears during embryonic development | Nature
Time of Update: 2021-03-25
Here we show that the surface epithelium of zebrafish and mouse embryos, which is the first tissue formed during vertebrate development,performs efficient phagocytic clearance of apoptotic cells through phosphatidylserine-mediated target recognition.
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New Crown Annual Summary Special Issue (2) | Research Progress on the Adaptive Immune Response Induced by SARS-CoV-2
Time of Update: 2021-03-25
Written by Tang Xiaotang | Xixinguan Anniversary Summary Special Issue (1) | SARS-CoV-2's ADE (antibody-dependent enhancement) research progress and inflammatory mechanisms The adaptive immune system
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Plant Cell | Li Jianfeng's Research Group at Sun Yat-Sen University Reveals New Mechanism of Negative Regulation of Plant Immune
Time of Update: 2021-03-25
On February 2, 2021, Li Jianfeng's research group at Sun Yat-sen University published a research paper entitled The receptor-like cytoplasmic kinase CDG1 negatively regulates Arabidopsis pattern-triggered immunity and is involved in AvrRpm1-induced RIN4 Phosphorylation in The Plant Cell, revealing the The Arabidopsis receptor cytoplasmic kinase CDG1 is a negative regulator of PTI, and AvrRpm1 can induce CDG1 to phosphorylate the Thr166 site of RIN4, resulting in plant ETS.
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"Nature" is heavyweight: adjusting immune cell metabolism may reverse brain aging!
Time of Update: 2021-03-25
This study found that immune cells such as macrophages and microglia in the brain and other parts of the body will undergo changes in their metabolic state with aging, converting more glucose into glycogen storage, resulting in their own energy supply something is wrong.
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Nature Sub-Journal | Fujian Medical University and other multi-unit cooperation, Chen Yuanzhong and others discovered the underlying mechanism of acute rejection of xenotransplantation
Time of Update: 2021-03-25
The lack of IFN-γ in the donor CD8 + T cells also leads to the PD-1-dependent depletion of intestinal protective CX3CR1hi mononuclear phagocytes (MNPs), which also increases the expansion of Tc22 cells.
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What is the different risk of infection in patients with RA using different biological agents?
Time of Update: 2021-03-25
Risk of Hospitalized Infection and Initiation of Abatacept Versus Tumor Necrosis Factor Inhibitors Among Patients With Rheumatoid Arthritis:A Propensity Score-Matched Cohort Study[J].
Overall infection risk in rheumatoid arthritis during treatment with abatacept, rituximab and tocilizumab;an observational cohort study[J].
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HLA-B27 positive = ankylosing spondylitis?
Time of Update: 2021-03-25
HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis.
Research status of ankylosing spondylitis and its related gene HLA-B27 detection[J] .
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Nat Immunol | Gasdermin D-dependent lectin release can trigger inflammation
Time of Update: 2021-03-25
In order to study this problem, the author took the bone marrow-derived macrophages of wild-type and caspase-11-deficient mice as the research object, and took the caspase-11 specific activator Escherichia coli as the stimulant to release the components outside the cell.
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The New Role of Raf-like Protein Kinases in Rice Immune Response in Mol Plant
Time of Update: 2021-03-25
2-OsMPK6 cascade phosphorylates the Raf-like kinase OsEDR1 and inhibits its The research paper "scaffold function to promote rice disease resistance" reveals the mutual regulation mechanism between a Raf-like protein kinase and mitogen-activated protein kinase (MAPK) signal cascade in rice immune response.
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JAMA: Intravenous infusion of immunoglobulin + methylprednisolone vs. The effect of simple infusion of immunoglobulin on the course of fever in children with multiple system inflammatory syndrome
Time of Update: 2021-03-25
Many children with MIS-C received empirical treatment based on Kawasaki disease guidelines, using intravenous immunoglobulin (IVIG) alone or in combination with corticosteroids.
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Collect during the epidemic!
Time of Update: 2021-03-25
Conclusion: It is safer for people with low immune function to receive inactivated vaccines; there is no contraindication to vaccination for patients receiving immunosuppressive therapy; there is no clinically significant interaction between vaccines and biological agents for the time being.
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A new revolution in the field of SLE therapy in China: Taitasip
Time of Update: 2021-03-25
The following is an estimate of the market size of Tetasep by comparing it with the only biologic drug belyumumab currently on sale in the field of SLE treatment in China.
The Phase IIb clinical trial of Taltazep in China consisted of 249 patients with moderate to severe SLE.
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How to use "gamma globulin" for these diseases in rheumatology?
Time of Update: 2021-03-25
In the field of rheumatism and dermatology, IVIg has been used to treat diseases such as autoimmune diseases and toxic epidermal necrolysis (Table 1).
The figure below shows the decision to use IVIg to treat severe autoimmune diseases.
The use of IVIg in the treatment of severe autoimmune diseases in dermatology.
