-
JCI Insight: New biomarkers may predict which pancreatic cancer patients will respond to CD40 immunotherapy
Time of Update: 2021-02-28
FEBRUARY 9, 2021 // -- In a recent study published in the international journal JCI Insight, scientists from the University of Pennsylvania and others found that inflammation in the blood may be used as a new biomarker to help identify patients with malignant pancreatic cancer who do not respond to the immunostimulation drug CD40 agonists.
-
The immune system is involved in stress-induced depression and anxiety
Time of Update: 2021-02-28
The entry of jaundice through the blood-brain barrier into the brain can cause the less protrusive glial cells in the amygdala region on the left side of the brain to activate, which in turn activates neurons, eventually leading to anxiety, depression and social disorders in mice, among other behavioral abnormalities.
-
JACI: Study reveals molecular mechanisms for severe allergic reactions
Time of Update: 2021-02-28
"This study combines clinical data from patients with carriers with severe allergic reactions and kars gene mutations with biogenic, functional and structural data showing abnormal function of the LysRS protein encoded by the gene," said margarita Martín, author of the study.
-
Mol Cell: Uncovering the special gene network of leukemia factors
Time of Update: 2021-02-28
'In this study, we designed a chemical genetic method that can shorten the analysis of transcription factors from the last few days to a few minutes,' said Dr. Kristy Stengel, a researcher at DOI:10.1016/j.molcel.2020.12.005.
-
Cell: Common fungi in the gut are like vaccines and can cause an immune response to prevent pathogenic fungal infections
Time of Update: 2021-02-28
Said Dr. Iliev, "There is no actual evidence of fungal infection in the healthy human body we are examining, so we started thinking about the potential function of these antibodies." " Iliev and his team have developed a platform that allows them to determine which intestinal fungi are targeted by antifellar antibodies in a patient's blood.
-
Sci Adv: Revealing new molecular mechanisms for reprogramming genes to improve the body's immune response is expected to help develop new antiviral and immunotherapy strategies
Time of Update: 2021-02-28
in paper, researchers revealed the molecular mechanisms by which deitycytes improve their antiviral and immune activation capabilities, noting that when interacted with the same source T cells, deduperate cells were able to reprogram gene expression by altering the genetic DNA markers on the surface.
-
Int J Mol Sci: Removing microRNAs from cancer cells may be expected to reverse the progression and spread of triple negative breast cancer
Time of Update: 2021-02-28
researcher Pinar Uysal-Onganer said: 'This is an important study that may help us gain a deeper understanding of the key role miRs play in malignant cancer types such as triple negative breast cancer; , breast cancer is the most common type of cancer among women in the UK, with one woman diagnosed every 10 minutes, according to available statistics.
-
JEM: Scientists have revealed for the first time the molecular mechanism by which intestinal corted cells regulate T-cell differentiation
Time of Update: 2021-02-28
February 9, 2021 // -- The intestinal immune cells contain a large number of immune cells, because they will continue to be exposed to a variety of antigens, such as bacteria and food, so the appropri
-
JEM: New drug helps treat breast and pancreatic cancer
Time of Update: 2021-02-27
Liu said: "All solid tumors have cancer-related fibroblasts, but in pancreatic and triple-negative breast cancers, the substate is so dense that there is usually no way for conventional drugs to penetrate it and treat cancer effectively." " substring can also help tumors hide from the body's immune system.
-
Nature: New crown patients become virus testing ground, constantly mutated to adapt to antibody pressure
Time of Update: 2021-02-27
, however, the virus samples left by the patient allowed the researchers to observe that during a prolonged period of chronic infection, the new coronavirus developed multiple mutations in the patient's body.
-
Nature: In the early stages of vertebrate embryos, endocysts devour to quickly remove defective cells
Time of Update: 2021-02-27
this is the first time that this biological process, called epithelial phagocytosis, has been shown to remove defective cells from newly formed vertebrate embryos.
Cooperative epithelial phagocytosis enables error correction in the early embryo.
-
EHJ: Reveals the molecular mechanisms by which air pollution increases the risk of cardiovascular disease in the population
Time of Update: 2021-02-27
In a recent study published in the international journal European Heart Journal, scientists from Massachusetts General Hospital and other institutions found that fine particulate matter may have harmful effects on the body's cardiovascular health by activating the production of inflammatory cells in the bone marrow, leading to inflammation of arteries.
-
Cell Rep: Uncover the molecular pathogenes of inhibited T-cells that promote the development of chronic immune diseases in the body
Time of Update: 2021-02-27
Photo Source: CC0 Public Domain Many years ago, researcher Reinhard Obst developed an animal model for research, focusing on T-assisted cells that express CD4 marker molecules and form the largest sub-group of T-cell cells, each of which recognizes a given protein fragment as an antigen.
-
Plos Genet: Ordinary people are naturally resistant to SARS-CoV-2
Time of Update: 2021-02-27
FEBRUARY 12, 2021 /--- According to a study published February 11 in the open-access journal PLOS Pathogen, in the majority of severe cases of COVID-19, most people can produce meso-antibodies against SARS-CoV-2.
-
Sick, old fast? eLife: This could be worms "making bad"
Time of Update: 2021-02-27
has been found that restorative worm therapy is not only effective in fighting allergic and autoimmune inflammatory diseases to some extent, but also in treating age-related inflammation later in life.
-
PNAS: How did the COVID-19 super-transmitter come about?
Time of Update: 2021-02-27
Dr. Chad Roy, author of the communication at the National Primate Research Center in Durham and director of infectious disease air biology, said the incidence of exhaled aerosols increased even in asymptomatic COVID-19 cases.
-
The first new bone marrow fibrosis drug in nearly a decade! Hundred-time Meishi Shiguibao JAK2 inhibitor Inrebic EU approved: will become a clinical new standard of care!
Time of Update: 2021-02-27
It is worth noting that Inrebic is the first new treatment for bone marrow fibrosis in Europe in nearly 10 years, and will also be the first daily oral therapy to significantly reduce spleen volume and symptom burden in patients with ruxolitinib treatment failure, inability to treat ruxolitinib or jak inhibitor primary treatment.
-
Npj Regen Med: Scientists may be developing new treatments for diabetes
Time of Update: 2021-02-27
FEBRUARY 16, 2021 // -- In a recent study published in the international journal npj Regenerative Medicine, scientists from Monash University and others uncovered barriers to cell regeneration in β, and the results may help scientists develop new treatments for diabetes and related diseases such as organ and tissue damage.
-
The study found that LIGHT plays an important role in critical viral pneumonia
Time of Update: 2021-02-27
tumor necrosis factor (TNF) is a common viral pneumonia causative factor, yet the role of LIGHT, another member of the family, in pneumonia caused by highly pathogenic influenza viruses has rarely been studied.
-
Cancer Res: The mechanism by which tumor-related macrophage activity is inhibited
Time of Update: 2021-02-27
once LXR is activated, the gene expression spectrum of tumor-related macrophages changes significantly, resulting in a decrease in their ability to produce immune-functioning molecules in the tumor micro environment," the study said.
