JACI: Study reveals molecular mechanisms for severe allergic reactions

February 10, 2021 /---Anaphylaxis is a systemic allergic reaction that may affect the skin, gastrointestinal, respiratory and cardiovascular systems.
most severe form of Anaphylaxis is anaphylaxis, which manifests it as hypotension and can lead to death.
reactions can be caused by a variety of causes, such as allergic reactions to food, drugs, or insect venom.
molecular mechanisms that cause such reactions to be severe are still unknown.
study, led by researchers at the University of Barcelona and IDIGBAPS, researchers analyzed mutations in a gene detected in patients with Polistes dominula allergies and recurrent anaphylactic shock.
the results, published in journal Of Allergy and Clinical Immunology, reveal a new molecular mechanism that controls the severity of allergic reactions.
(Photo Source: www.pixabay.com) researchers performed bio-chemical, functional and structural features of kars gene mutations detected in patients.
"This study combines clinical data from patients with carriers with severe allergic reactions and kars gene mutations with biogenic, functional and structural data showing abnormal function of the LysRS protein encoded by the gene," said margarita Martín, author of the study.
"LysRS protein is a double-functioning enzyme.
It plays a key role in protein synthesis and is regulated by phosphorylation in the high affinity of immunoglobulin E (IgE) high affinity, and activates the MITF transcription factor, which is involved in transcription of an inflammatory medium in fat cells.
the inflammatory processes in the immune system caused by allergic reactions.
from a bio-chemical point of view, the results show that the replacement of arginine in the LysRS protein amino acid 542 causes structural changes.
these changes affect the protein, which moves toward the nucleus and stops its function in protein synthesis, activating MITF transcription factors in the absence of stimulation.
" this leads to an increase in the synthesis of inflammatory media when allergens are present and the activity of fat cells, leading to anaphynactic shock.
mechanism identified in this study involves signaling basis IgE-LysRWS-MITF, which will control the severity of allergic reactions.
will enable us to identify patients at risk of severe allergic reactions and develop appropriate precautions," said.com Margarita Martín, "Source: Researchers identify a new molecular mechanism related to severe anaphylaxis Original source: Pau Rib?et al, Mutation In Kars: A Novel Mechanism For Severe Anaphylaxis, of Allergy and Clinical. DOI: 10.1016/j.jaci.2020.12.637