Sci Adv: Revealing new molecular mechanisms for reprogramming genes to improve the body's immune response is expected to help develop new antiviral and immunotherapy strategies

9, 2021 // -- In a recent study published in the international journal Science Advances, scientists from the National Centre for Cardiovascular Research in Madrid, Spain, and others found that dendritic cells or reprogram genes that initiate special immune responses in the body can improve the body's immune response.
Atrocytes are specialized antigen-presenting cells that can open up adaptive immune responses in the body, as well as capture and process possible pathogens at different tissue and body entry points and transport them to the lymph nodes; A special structure called immune synapse establishes communication mechanisms with T lymphocytes, which promote the processing of infectious factors by synapses and presents them to T cells so that T cells can effectively identify and turn on specific T-cell immune responses.
Photo Source: CNIC So far, the activation of T lymphocytes is considered to be the primary function of degenerative cells, but in this study, researcher Francisco Sánchez-Madrid et al. found that degenerative cells are able to receive information from T cells through immune synapses, which the researchers say can send instructions to induce changes in the gene expression process of degenerative cells and promote the expression of genes associated with movement, antiviral response, and secretion, thereby increasing the ability of degenerative cells to produce protective immune responses.
'In this study, we describe how changes in gene expression are accompanied by changes in DNA's appearance genetic markers, which can make brief changes in a particular gene to promote or hinder gene expression,' the researchers explained.
one of the genes that enhances its expression and accessability is the Ccr7 gene, which encodes cell migration bodies on synth cells so that it can target the lymph nodes.
The researchers also found that when immune synapses were added, synthesized cells were able to migrate more effectively to the lymph nodes, where a variety of processes involving specific or appropriate immune responses occurred. in
paper, researchers revealed the molecular mechanisms by which deitycytes improve their antiviral and immune activation capabilities, noting that when interacted with the same source T cells, deduperate cells were able to reprogram gene expression by altering the genetic DNA markers on the surface.
these changes can improve the cell's motion so that they can quickly reach the activation point of the immune response and represent a new mechanism for enhancing the immune response.
The researchers concluded that the findings of this paper are important for developing new vaccines and immunotherapy strategies, for example, the mechanisms described by the researchers could be used to produce super-migrating synhapus post-synth cells to induce a stronger and more effective immune response.
() Original source: Ana Alcaraz-Serna, Eugenio Bustos-Morán, Irene Fernández-Delgado, et al. Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells, Science Advances03 Feb 2021: Vol. 7, no. 6, eabb9965 DOI: 10.1126/sciadv.abb9965