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British scientists build a "portrait" of rheumatoid arthritis molecules, further research on chronic diseases
Time of Update: 2021-03-25
Scientists from Queen Mary University of London, University of Cambridge reported their work in this area: Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes.
Lewis et al, Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes,, Cell Reports 28, 2455–2470
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A review of the research progress of new antiviral drugs for chronic hepatitis B
Time of Update: 2021-03-25
73 log10 IU/mL, respectively; the combined treatment group and the entecavir single-agent group, the mean values of HBsAg decline were 0.
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How to treat osteoarthritis, which is common to 200 million people?
Time of Update: 2021-03-25
Osteoarthritis (OA) is a group of heterogeneous diseases characterized by articular cartilage damage and bone hyperplasia at the edges of joints caused by a variety of factors.
Senescent cells can be widely distributed in joint tissues (including articular cartilage, subchondral bone, subpatellar fat pad), secrete SASP-related inflammatory factors, and induce inflammation.
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Plant Cell | Highly variable NLR immunoreceptor and prediction of its binding site with effector
Time of Update: 2021-03-25
In conclusion, this article found that the method of using evolutionary tree and Shannon entropy can be used to analyze the evolutionary relationship of NLR within species, and predict whether NLR can directly bind to effectors and the sites where they bind.
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What are the implications for new coronavirus adaptive immunity for vaccine development?
Time of Update: 2021-03-25
You can find the submission policy of COVID-19-related papers, as well as the papers on the epidemic and virus published in the journals of Cell Press on the resource center page.
The latest review published in the journal Cell of Cell Press, titled "Adaptive immunity to SARS-CoV-2 and COVID-19", was published online by the center.
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HLA-B27 positive = ankylosing spondylitis?
Time of Update: 2021-03-25
HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis.
Research status of ankylosing spondylitis and its related gene HLA-B27 detection[J] .
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Eur Arch Otorhinolaryngol: The relationship between nasal cavity patency and changes in orofacial muscle function in patients with asthma and rhinitis
Time of Update: 2021-03-25
Finally, the researchers pointed out that children and adolescents with asthma and rhinitis have reduced nasal patency, but also changes in orofacial muscle function, such as insufficient positioning of the mandible and facial muscle tension when swallowing fluid.
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Paper Interpretation | Nature: How does the human body "remember" the new coronavirus
Time of Update: 2021-03-25
The authors concluded that the continued existence and evolution of memory B cells indicate that when SARS-CoV-2 reinfection occurs, the human body may quickly produce powerful virus-neutralizing antibodies.
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Express | Approximately US$3 billion in autoimmune disease drug pipeline, Horizon plans to acquire Viela Bio
Time of Update: 2021-03-25
Horizon will harvest Viela Bio’s approved anti-CD19 monoclonal antibody Uplizna (inebilizumab-cdon) for the treatment of neuromyelitis optica spectrum disease (NMOSD), a variety of research therapies in the research and development pipeline, and Viela Bio’s autoimmune Scientific expertise in sexual diseases and profound experience in biological product development.
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[Nature] Stanford scientists revealed that the key to reversing cognitive decline is an immune cell related to inflammation
Time of Update: 2021-03-25
This article is converted Medicine original, reproduced please indicate the source Author: Yun Introduction: Recent "Nature" journal published a research paper from the Stanford University School of Medicine, the scientists pointed out that aging affects the brain, a key factor in cognitive decline It is a macrophage-a type of immune cell related to inflammation.
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Cell: "New Coronary Pneumonia Single Cell Research China Alliance" Reveals the Immunological Features of New Coronary Pneumonia
Time of Update: 2021-03-25
This study also lays the foundation for the analysis of the impact of the severity of new coronary pneumonia, the stage of disease, age, gender, and other technical factors on the composition of immune cells in the peripheral blood of the body.
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Rheumatism makes you diagnose, will you?
Time of Update: 2021-03-25
Figure 6 Liver biopsy results for this patient, Professor Liu Yanying emphasized that although the clinical manifestations resemble lupus erythematosus, but the symptoms of immune disease are not typical and there is no obvious improvement after treatment, it is necessary to consider whether it is other diseases Up.
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System inventory | In 2020, Cao Xuetao’s team published 6 research results/reviews, making significant progress in the field of immunology
Time of Update: 2021-03-25
On December 15, 2020, Xuetao Cao’s team published online research results titled Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation on Immunity.
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Promote the individualized chronic disease management of RA from four dimensions to achieve "long-term security"
Time of Update: 2021-03-25
prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis[J].
Introduction and prevalence of remission in Chinese patients with rheumatoid arthritis[J] .
Expert consensus on chronic disease management of patients with rheumatoid arthritis (2014 edition)[J].
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How difficult is it to diagnose rheumatism?
Time of Update: 2021-03-25
Case characteristics: The patient’s kidneys were large in appearance, right kidney hamartoma, suggesting occult renal insufficiency; elevated IgG4 and hypocomplementemia; multiple lymphadenopathy; bilateral inguinal masses without obvious cause, progressive increase Da et al; (For details, please click "The increase in blood creatinine, the inguinal lymph nodes are getting bigger and bigger, and it turned out to be.
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Can rheumatism patients who take hormones and immunosuppressants get the new crown vaccine?
Time of Update: 2021-03-25
Due to the imbalance of the autoimmune system and the use of glucocorticoids, immunosuppressants or other biological agents and targeted drugs to suppress immune and inflammatory reactions, patients with rheumatic immune diseases will have reduced defenses against pathogens and may be more susceptible to infection New coronavirus, and the risk of serious complications after infection is higher, so more attention should be paid to the issue of vaccination.
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"Nature": Tsinghua Professor Qi Hai's research group reported a new mechanism for high-affinity antibody screening
Time of Update: 2021-03-25
Researchers in the Qihai group speculated that there may be a mechanism that selectively promotes the collision of T cells and high-affinity B cells, thereby increasing the efficiency of antibody affinity maturation.
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【New Phytol】Shanghai Normal University reveals that peptides play an important role in plant immune response
Time of Update: 2021-03-25
Recently, Meng Xiangzong’s research group at Shanghai Normal University published a research paper entitled Perception of the pathogen-induced peptide RGF7 by the receptor-like kinases RGI4 and RGI5 triggers innate immunity in Arabidopsis thaliana on New Phytologist, revealing the secretion of Arabidopsis thaliana.
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NC | Significant discovery!
Time of Update: 2021-03-25
More importantly, the authors screened out the Fusarium proteome-encoding SCOOP-like sequence through comparison, and synthesized the corresponding small peptides for induction, and found that the pathogen produced a dependent immune response to MIK2.
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8+ T cell receptor diversity analysis
Time of Update: 2021-03-25
Figure 4 Calculate the diversity index on each TCR chain of the TCGA tumor sample and compare it with the modeled entropy measure 4.
