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February 27, 2021 // - Recently, a research report entitled "Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial" was published in the international journal Nature Medicine In, scientists from the University of California and other institutions through research are expected to use bacteria to successfully resist bacteria that accelerate the occurrence of eczema.
Nature Medicine
In the article, the researchers conducted the first human phase 1 double-blind clinical trial to investigate the safety and mechanism of action of this specific bacteria, hoping to use it to help treat patients with eczema.
Image source: CC0 Public Domain
Researchers have screened more than 8,000 isolates of Staphylococcus on the skin of people who have never had eczema, and identified some strains that can inhibit the growth of Staphylococcus aureus.
Researcher Gallo said, this is how we found the universal strain, and this is one of more than 8,000 strains.
The success in the animal model prompted the scientists to launch a phase 1 clinical trial using bacterial therapy to treat 54 patients with eczema; the results showed that two-thirds of the participants had levels of Staphylococcus aureus on their skin There has been a sharp drop, and eczema has improved.
Healthy human skin is full of bacteria.
Finally, the researcher Gallo said that according to our research, we have determined that this reasonable method of treating atopic dermatitis seems to be safe to treat patients with eczema; and it is relatively simple because it is just a kind of Ointment, and avoid the side effects of steroids and other drugs that target the host's immune system.
Reference materials:
Reference materials:[1] Nakatsuji, T.
[1] Nakatsuji, T.
【2】com/news/2021-02-bacteria-exacerbate-eczema.
by University of California-San Diego