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March 26, 2021 // - Recently, a research report entitled "The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases" was published in the international journal Nature Communications , from the University of Turku Scientists from other institutions have solved a long-standing puzzle in the scientific community through research, that is, how organisms can effectively distinguish between RNA and DNA components in the process of gene expression, which may pave the way for the design of new antiviral drugs the way.
Nature Communications scientists from Turku University and other institutions have solved a long-standing puzzle in the scientific community through research, that is, how organisms can effectively distinguish between RNA and DNA components in the process of gene expression.
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All cell organisms can use two types of nucleic acids (ie RNA and DNA) to store, spread and use their genetic information.
DNA polymerase can avoid the construction of RNA by carrying a cavity structure called the active site.
DNA polymerase can avoid the construction of RNA by carrying a cavity structure called the active site.
The cavities in the active site of RNA polymerase deform DNA components
In order to understand how RNA polymerase avoids the use of DNA components, the researchers performed complex biochemical measurements using carefully designed RNA polymerases altered by engineered mutations.
Image source: Nature Communications (2021).
Nature Communications
Human and viral RNA polymerases have different ways of selecting RNA components.
By carefully comparing the newly discovered selective mechanism with the results of other research teams, the researchers concluded that viruses and human RNA polymerase can use different mechanisms to reject DNA components.
By carefully comparing the newly discovered selective mechanism with the results of other research teams, the researchers concluded that viruses and human RNA polymerase can use different mechanisms to reject DNA components.
Reference materials:
[1] Makinen, JJ, Shin, Y.
[1] Makinen, JJ, Shin, Y.
【2】org/news/2021-03-ancient-problem-nucleic-acid-synthesis.
by University of Turku
