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Highlights of Science Journal on March 12, 2021
Time of Update: 2021-04-28
The relevant research results were published in the Science Journal on March 12, 2021, with the title of the paper "Type III secretion system effectors form robust and flexible intracellular virulence networks".
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PNAS: Studying donkeys helps understand the mechanism of HBV infection
Time of Update: 2021-04-28
"With the discovery of a new type of hepatitis B virus that can cause long-term infections in donkeys and zebras, we now have the opportunity to better understand the chronic course of the disease, thereby reducing or preventing serious clinical consequences," Charité-Berlin Said Professor Jan Felix Drexler, DZIF researcher at the University Medical Department.
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How to understand the low blood sodium content of the elderly?
Time of Update: 2021-04-28
07400717Researchers have found that over time, slightly lower blood sodium levels are related to cognitive impairment and cognitive decline.
07400717Researchers have found that over time, slightly lower blood sodium levels are related to cognitive impairment and cognitive decline.
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never expected! Science: The relationship between the intestinal immune system and nutrition is so close!
Time of Update: 2021-04-28
In addition, studies have shown that the remodeling of intestinal epithelial cells occurs during the reaction to certain infections, which may also be the basis for their adaptation to different nutrients.
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The body is numb and weak, be careful of rheumatism!
Time of Update: 2021-04-27
Figure 3: Pathological examination of sensory neuron neuropathy The pathological feature of chronic inflammatory demyelinating multiple radiculopathy (CIPD) is chronic demyelination, which is mainly manifested by numbness and weakness of the limbs; electromyography indicates sensory motor neuropathy.
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Professor Chunfu Zheng was invited to publish a review: the latest research progress of DDR protein family in innate immune signaling pathways
Time of Update: 2021-04-27
Recently, Professor Chunfu Zheng was invited to publish a review in International Reviews of Immunology: The Crosstalk between DNA Damage Response Components and DNA-sensing Innate Immune Signaling Pathways.
This article systematically reviews the latest research progress of DDR protein family in innate immune signaling pathways.
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Chen Xuewei's team from Sichuan Agricultural University published a review on the important regulatory role of non-coding RNA in the process of plant immunity
Time of Update: 2021-04-27
On March 20, 2021, Chen Xuewei’s team from the State Key Laboratory of Crop Gene Resources Discovery and Utilization of Sichuan Agricultural University was invited to write a review article titled Role of non-coding RNAs in plant immunity in the journal Plant Communications.
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Ann Rheum Dis: Efficacy and safety of tanalizumab in the treatment of hip or knee osteoarthritis
Time of Update: 2021-04-23
In the 24th week, compared with the placebo group, tanizumab 5 mg in WOMAC pain (least squares mean difference ± SE -0.
feeling abnormalIn summary, the results of the study show that tanalizumab 5 mg can significantly improve the pain, body function and PGA-OA of patients with osteoarthritis, but tanalizumab 2.
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Immunity | Connecting stem cell fate and gene expression through the "time machine"
Time of Update: 2021-04-23
In order to solve this problem, on April 15, 2021, the Australian Shalin Naik team published Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development in Immunity, by isolating and differentiated early sister cells and performing sequencing and Functional tests link the cell fate and stem cell gene expression, which occur at different times.
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Immunity | Jiang Zhengfan's team reveals that mucopolysaccharides (sulfated glycosaminoglycans) are the cause of STING co-ligand and STING translocation to Golgi activation
Time of Update: 2021-04-23
Fang Run and Jiang Qifei from the laboratory of Jiang Zhengfan cleverly used the self-activating mutant of STING to induce cell death, and performed a CRISPR-Cas9-mediated genome-wide screening in diploid cells HT1080 , Found that a number of key genes involved in the synthesis of sulfated glycosaminoglycans (mucopolysaccharides) are highly enriched (Figure 1).
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Ann Intern Med: The effect of zedoary turmeric extract on knee arthritis symptoms and effusion synovitis
Time of Update: 2021-04-23
gov/32926799/" target="_blank" rel="noopener">Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis: A Randomized Trial .
gov/32926799/" target="_blank" rel="noopener">Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis: A Randomized Trial in this message
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Ann Rheum Dis: Large-scale meta-analysis identified 11 new susceptibility loci for rheumatoid arthritis
Time of Update: 2021-04-23
8% of the heritability of SNPs in East Asian and European races respectively, and confirmed 71 known non-human leukocytes Antigen (HLA) susceptibility locus immunity Newly discovered RA susceptibility locusNewly discovered RA susceptibility locusIt can be seen that this study provides useful insights into the genetic etiology of RA and the pathogenesis of RA caused by mutations.
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Lupus patients got cancer after taking this medicine
Time of Update: 2021-04-23
Another possibility in this case is that the patient already had renal cell carcinoma during the active stage of lupus nephritis, but the latter was not detected by ultrasound, and subsequent cyclophosphamide treatment may accelerate the growth of the cancer.
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"Refractory gout in the elderly" is complicated and tricky.
Time of Update: 2021-04-23
This article is published by Yimaitong authorized by the author, please do not reprint without permission. Introduction: "Refractory gout in the elderly" is complicated and tricky? The main points
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Immunity: The team of Academician Dong Chen of Tsinghua University discovered IL-17D receptor for the first time and revealed its function
Time of Update: 2021-04-23
On April 13, 2021, the team of Academician Dong Chen from the Institute of Immunology of Tsinghua University published a research paper titled: Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93 in the top immunology journal Immunity.
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JAHA: Patients with rheumatoid arthritis who do not respond well to disease-altering antirheumatic drugs are at increased risk of acute coronary syndrome
Time of Update: 2021-04-23
Patients With Rheumatoid Arthritis With an Inadequate Response to Disease‐Modifying Antirheumatic Drugs at a Higher Risk of Acute Coronary Syndrome .
018290Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs at a Higher Risk of Acute Coronary Syndrome in this message
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Neurology: Vitamin D, smoking and EBV can predict long-term cognitive function in patients with multiple sclerosis
Time of Update: 2021-04-23
In the new study, the researchers extended the follow-up period to 11 years, and examined whether vitamin D, smoking, and anti-EBNA-1 antibodies can help predict long-term cognitive function and axons early after the first manifestation of relapsing-remitting MS For completeness, the research results have been published in Neurology.
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Anticardiolipin antibody is "positive", beware of these three situations!
Time of Update: 2021-04-23
In the detection of aPLs-related antibodies, the three simultaneous positives of LA, ACA, and anti-β2-GPI antibodies are more likely to form thrombosis than one or two of them [3].
APS is an autoimmune disease mediated by aPLs, with recurrent thrombosis and miscarriage as the main clinical features.
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Sign up for the Metz applet, 100 Metz points will be given for free, and there will be warm guns, phone bills and other gifts to be given-Sunflower Primary Doctor Platform
Time of Update: 2021-04-23
cn/ipsen/sporty/show-details/3074/2">digestive , respiratory medicine, neurology, dermatology, department of Otolaryngology, Rhinology, department of pediatrics, Division of allergy doctors, registered, Janssen public attention 72 hours review and correct information is available after in-kind incentives, non Metz users of primary doctors will get Metz points for medsci.
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Ann Rheum Dis: The use of vitamin K antagonists is associated with an increased risk of the onset and progression of osteoarthritis
Time of Update: 2021-04-23
Among new anticoagulant users, patients with high VKORC1 (BB) expressing haplotypes and MGP OA risk alleles (rs1800801-T) have an increased risk of OA development and progression (OR=4.
Thus, these findings support the importance of vitamin K and vitamin K-dependent proteins (such as MGP) in the pathogenesis of OA.
