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Scientists decode the kinetic changes of p53 in different tissues, or hope to help develop new anti-cancer therapies!
Time of Update: 2021-04-29
Scientists from Harvard Medical School and other institutions Through research, we show that revealing the dynamic properties of tumor suppressor proteins may help determine whether tissues will survive radiation.
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In cooperation with Xi’an Jiaotong University and other institutions, Jin Yan/Chen Xin and others have developed new materials to promote immune tolerance in mouse autoimmune models
Time of Update: 2021-04-28
Specifically, in the experimental model of colitis, IHM rapidly releases monocyte chemoattractant protein-1 after intravenous administration, which recruits activated T cells and then induces their apoptosis through Fas ligand on the surface of IHM.
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New drugs for rare diseases!
Time of Update: 2021-04-28
com" target="_blank">Recently, Apellis and Swedish Orphan Biovitrum AB (SOBI) jointly announced the evaluation of pegcetacoplan (APL-2, a C3 inhibitor) in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) head-to-head Phase 3 PEGASUS study ( NCT03500549) results have been published in the international medical journal "New England Journal of Medicine" (NEJM).
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Professor Zhao Futao: From the outside to the inside, let you have a more comprehensive understanding of Sjogren’s syndrome
Time of Update: 2021-04-28
"Benefiting from a large number of basic research and clinical research data support (Table 2), the 2020 "Primary Sjogren’s Syndrome Guidelines" will include IGU in the recommended list of immunomodulators, and indicated that SS patients with systemic involvement can use it.
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JEM | Yang Shuo/Zhou Jiawei/Hu Gang collaborate to reveal the immunological mechanism of inflammasome AIM2 protein-mediated multiple sclerosis
Time of Update: 2021-04-28
Ting research group of the University of North Carolina at Chapel Hill also reported in Nature that AIM2 inhibits the occurrence of multiple sclerosis and other autoimmune diseases through non-inflammatory body function.
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A 29-year-old girl who took "herbal supplements" for half a year had rheumatism? | Wind list finalized
Time of Update: 2021-04-28
Seeing this, you may have some questions: Since drug-induced lupus (DIL) is considered, why the patient's kidney condition has not improved after stopping this herbal supplement?
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Bioelectricity: Electromagnetic fields can affect the spread of breast cancer cells
Time of Update: 2021-04-28
0048Original Source: Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity, Bioelectricity
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Science: Heavy!
Time of Update: 2021-04-28
March 9th, 2021 // - Recently, in a research report published in the international journal Science , scientists from Yale University and other institutions have combined the liver with humanized growth factors to improve The production and survival rate of human red blood cells circulating in the host body of immunodeficiency mice.
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What changes will the introduction of IL-17A inhibitors into medical insurance bring to the AS "ecological circle"?
Time of Update: 2021-04-28
Picture: The scene of the 2nd Novartis Rheumatism and Immunity Summit Forum (Opening Session) 1 Extract from the conference: Innovative drugs are included in medical insurance to promote the clinical diagnosis and treatment of AS.
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Blood Adv: Blood test can identify severely ill patients with COVID-19
Time of Update: 2021-04-28
2020003568For this new study, researchers at Yale University used proteomic analysis (a screening of multiple proteins in the blood) to analyze samples from 100 patients who will continue to experience varying levels of COVID-19 severity.
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Eli Lilly's IL-23p19 inhibitor mirikizumab in the treatment of ulcerative colitis (UC) phase 3 clinical study was successful!
Time of Update: 2021-04-28
com/tags/%E7%A4%BC%E6%9D%A5/">Eli Lilly (Eli Lilly) recently announced that the new anti-inflammatory drugs mirikizumab assess the treatment of moderate to severe ulcerative colitis (UC) in three LUCENT-1 study (NCT03518086) reached the primary endpoint and key secondary endpoints of all.
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Classic Hodgkin's Lymphoma (cHL) new drug!
Time of Update: 2021-04-28
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">Adult and pediatric patients with relapsed or refractory classic Hodgkin’s lymphoma (r/r cHL) who have failed the treatment of bioon.
In October 2020, the US FDA approved Keytruda as a single-drug therapy for second-line treatment of relapsed or refractory classic Hodgkin lymphoma (r/r cHL) adult patients.
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Sci Immunol: Identify special genes that play a key role in the differentiation of natural killer cells!
Time of Update: 2021-04-28
March 19, 2021 // --Recently, a research report titled "transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation" was published in the international journal Science Immunology , from multiple research institutions in Europe and the United States Through research, scientists have discovered a special gene that plays a key role in the differentiation of natural killer cells.
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Nat Commun: Gene therapy can be effective for decades
Time of Update: 2021-04-28
html">Cellular benefits of gene therapy seen decades after treatmentOriginal source: Natalia Izotova et al, Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans, Nature Communications (2021).
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Rongchang Bio-Tetacept was approved, the second new drug for systemic lupus erythematosus in 60 years
Time of Update: 2021-04-28
Overexpression of these factors is an important cause of systemic lupus erythematosus (SLE) and other autoimmune diseases related to B lymphocytes.
According to the key clinical research results published by Rongchang Biological, the systemic lupus erythematosus response index (SRI) of the high-dose Taltazep group for 48 weeks was significantly higher than that of the placebo control group (79.
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Gilead and Merck team up to develop a new long-acting HIV drug
Time of Update: 2021-04-28
The two companies said in a statement that they aim to combine two current drug therapies to provide a new and meaningful treatment option for HIV patients (HIV is the virus that causes AIDS).
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"Nature" Sub-Journal: The mechanism of anti-inflammation when hungry is found! Scientists have found that fasting can inhibit the function of helper T cells and inhibit the production of cytokines. It is effective if you are hungry for a long time | Clinical Discovery
Time of Update: 2021-04-28
This suggests that a longer period of fasting may have a sustained effect on the expression of genes involved in T cell immune regulation.
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Latest research progress of CRISPR/Cas in February 2021
Time of Update: 2021-04-28
Mol Cell: New gene editing technology allows CRISPR-Cas9 to edit DNA sequentially doi:10.
A new CRISPR technology may revolutionize gene therapy to treat human genetic diseasesRecently, in a research report titled "In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice" published in the international journal Nature, scientists from the United States MIT and the Broad Institute reported a landmark gene therapy Milestone research results.
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Interpretation of Cell papers! Reveal the metabolic mechanism that controls the production of memory T cells
Time of Update: 2021-04-28
Jude Children’s Research Hospital in the United States revealed a previously unknown biological mechanism through which the immune system produces memory T cells to kill bioon.
html">bacterialIn this new study, the authors tried to map the metabolic mechanisms that control how the immune system decides to produce memory T cells.
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Highlights of Science Journal on March 12, 2021
Time of Update: 2021-04-28
The relevant research results were published in the Science Journal on March 12, 2021, with the title of the paper "Type III secretion system effectors form robust and flexible intracellular virulence networks".