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Turning waste into treasure! Not effective against Alzheimer's disease, but may be used to treat cancer
Time of Update: 2021-12-04
BACE1 inhibitors used to be potential drugs for the treatment of Alzheimer's disease, and the scientific community has also expressed great expectations for it .
Therefore, researchers have speculated that inhibiting the function of BACE1 can reduce amyloid plaques, which can be used to treat Alzheimer's disease .
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Comparison of air pollution exposure between lung cancer patients who have never smoked and previously smoked
Time of Update: 2021-12-04
Journal of Thoracic OncologyThe study compared the gender, race, outdoor and indoor air pollution exposure of newly diagnosed lung cancer patients who had never smoked with those who had previously smoked .
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UK real-world research proves that HPV vaccine can reduce cervical cancer by 87%
Time of Update: 2021-12-04
Prevent Lancet DiagnosisIn England, the vaccine program started in 2008 when a bivalent vaccine-Cervarix-was used to protect women from the two most common types of HPV .
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J Clin Oncol: The treatment compliance of patients with early-onset colorectal cancer is better than that of late-onset patients, but the prognosis is worse!
Time of Update: 2021-12-04
Compared with patients with late-onset colorectal cancer, patients with early-onset colorectal cancer have a significantly worse cancer-specific prognosis, especially for high-risk stage III colorectal cancer patients: the 3-year recurrence-free survival rate is lower (54% vs 65%) ; Hazard ratio [HR] 1.
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JAMA Psychiatry: Clinical trials have confirmed that this "psychedelic mushroom" can actually treat depression with significant effects
Time of Update: 2021-12-04
This new clinical study shows that psilocybin, the effective chemical component of psychedelic mushrooms, can effectively improve the symptoms of patients with major depression (MDD), and has the advantages of rapid response, long-lasting efficacy and small side effects.
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Returning from Targeting-Victory in Wangji Targeted Therapy of Lung Cancer
Time of Update: 2021-12-04
Primary lung cancer (hereinafter referred to as lung cancer) is one of the most common malignant tumors in the world and in China . With the increase of smoking and environmental pollution, the inci
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J Urol: Are new urine storage dysfunction common after radical prostatectomy?
Time of Update: 2021-12-04
Similarly, non-white people were associated with an increased risk of new-onset urine storage dysfunction in both analyses, but did not reach a significant level in the sensitivity analysis (main analysis: OR 1.
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[Cell Journal] Yu Dihua’s team found that safe and low-cost antihistamines can improve the effect of cancer immunotherapy
Time of Update: 2021-12-04
https:// If it is indeed effective in prospective clinical trials, then targeting HRH1 may be used as a treatment and checkpoint blockade Combined to overcome immunotherapy resistance and improve treatment results, especially for patients with previous allergies or high plasma histamine levels .
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Front Oncol: The efficacy and safety of PD1 inhibitor penpulimab combined with Anlotinib in the first-line treatment of Chinese patients with unresectable hepatocellular carcinoma (uHCC)
Time of Update: 2021-12-04
The Chinese People's Liberation Army General Hospital team conducted a study to evaluate the efficacy and safety of humanized anti-PD-1 IgG1 antibody penpulimab combined with Anlotinib in the first-line treatment of unresectable hepatocellular carcinoma (uHCC) patients in China .
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【OC Archives】Combined with a variety of underlying diseases, Nirapali decisively started to provide sustained benefits for patients with advanced ovarian cancer and liver dysfunction
Time of Update: 2021-12-04
CT of the pelvis and abdomen: the abdominal cavity and pelvic effusion are reduced compared with the previous ones, and the left appendage is cystic and solid (92×85×70mm), considering the malignant ovarian tumor; multiple small lymph nodes on both sides of the pelvic wall and retroperitoneum; thickening of the greater omentum Shadow of nodules, consider metastasis (Figure 1) .
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Ann Oncol: Large-scale prospective GWAS identification of single nucleotide polymorphisms (SNPs) predicting oxaliplatin-mediated peripheral sensory neuropathy (PSN)
Time of Update: 2021-12-04
Recently, a team from Japan has carried out related research, trying to use genome-wide association studies ( GWAS ) methods to identify single nucleotide polymorphisms (SNPs) that can predict L-OHP-mediated PSN .
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JAMA Oncology: All-trans retinoic acid combined with arsenic trioxide has a significant effect on childhood leukemia
Time of Update: 2021-12-04
A phase III clinical trial conducted by the Childhood Oncology Group showed that a combination of drugs is very effective for children with standard and high-risk acute promyelocytic leukemia (also known as APL) .
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HER2 and ER are not expressed, and there are 8 popular targets for triple-negative breast cancer
Time of Update: 2021-12-04
← Swipe left and right to view, click [Read the original text] to learn more → Triple Negative Breast Cancer (TNBC) is a very aggressive and heterogeneous basal-like tumor, accounting for 15-20% of breast cancer cases, three classics Targets: estrogen receptor (ER), progesterone receptor (progesterone receptor) and human epidermal growth factor receptor 2 (HER2) lack expression .
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In addition to thrombolysis and lowering blood pressure to treat dementia, can ta also make oral ulcer patients eat it?
Time of Update: 2021-12-04
The purpose of this study is to study the changes in mouse body weight, information and epithelial cell regeneration to determine the role of crude nattokinase extract NCE in the treatment of oral mucositis .
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Nature Biomedical Engineering: Put a silica coat on cancer cells to make cancer vaccines, which can eradicate tumors and can be stored for a long time
Time of Update: 2021-12-04
Nature Biomedical Engineering Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patternsThe study demonstrated that cancer vaccines can be made by low-temperature silicification of tumor cells, storing tumor antigens in a nano-silica layer, and then modifying the silicified surface with pathogen-related molecular patterns .
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Merck and Dragonfly are working together again!
Time of Update: 2021-12-04
Li Fuying as Vice President & Head of the Pharmaceutical Affairs DepartmentMedClub broke the news on November 29, 2021/MedClub PR News/-- Dragonfly Therapeutics recently announced that Merck has obtained a license from Dragonfly for its second TriNKET™ immunotherapy drug candidate .
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Cancer Cell: Determinants of anti-PD-1 response and drug resistance in advanced renal cell carcinoma
Time of Update: 2021-12-03
Importantly, almost all of these genes are mainly expressed in non-responders before treatment, indicating that HERV and LTR elements that are highly specific to ccRCC are overexpressed before treatment in non-responders, and are related to anti-tumor immune responses and anti-PD- 1 Reaction defect is related .
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Thorac Cancer: Early application of EGFR-TKIs can improve the prognosis of unresectable stage III EGFR-mutant lung adenocarcinoma
Time of Update: 2021-12-03
PFS, PFS2 and OS between groups PFS, PFS2 and OS between groups PFS, PFS2 and OS between groupsAfter adjusting for possible confounding factors and using Cox proportional hazard regression analysis, the study found that in patients with EGFR-mutant adenocarcinoma, early EGFR-TKI treatment was an independent good prognostic factor compared with previous CCRT (HR 0.
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Nat Med: The efficacy and safety of PD-L1 inhibitor durvalumab combined with platinum + pemetrexed in the treatment of previously untreated and unresectable malignant pleural mesothelioma (MPM): Phase II clinical study PrE0505
Time of Update: 2021-12-03
Recently, Nature Medicine published a magazine II clinical study PrE0505 (NCT02899195) results, mainly to assess the anti- PD-L1 suppression agent durvalumab Plus Platinum + pemetrexed treatment of previously untreated, unresectable malignant pleural mesothelial Efficacy and safety of tumors (MPM) .
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Clin Cancer Res: Anti-CCR4 monoclonal antibody Mogamulizumab combined with nivolumab in the treatment of locally advanced or metastatic solid tumors
Time of Update: 2021-12-03
Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors .
CCR-21-2781Mogamulizumab in Combination with Nivolumab in a Phase I / II Study of Patients with Locally Advanced or Metastatic Solid Tumors in this message
