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Ann Oncol: Large-scale prospective GWAS identification of single nucleotide polymorphisms (SNPs) predicting oxaliplatin-mediated peripheral sensory neuropathy (PSN)

 Last Update: 2021-12-04
 Source: Internet
 Author: User

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Oxaliplatin (L-OHP) is a third-generation platinum compound and a commonly used chemotherapy drug for colorectal cancer

The prospective GWAS study included 1379 patients with stage II/III colon cancer who received L-OHP-based (mFOLFOX6/CAPOX) adjuvant chemotherapy in a phase II (JOIN/JFMC41) or phase III (ACHIVE/JFMC47) trial

Clinical features

Among the 1379 patients included in the GWAS analysis, the data of 1364 patients were analyzed

The researchers then explored related SNPs that can predict the recovery time of PSN

The researchers then explored related SNPs that can predict oxaliplatin-mediated allergic reactions (AR)

Finally, GWAS explores related SNPs that can predict disease recurrence

In summary, the study failed to find meaningful SNPs that can predict oxaliplatin-mediated PSN, and there are greater clinical challenges in follow-up

Original source:

Kanai M, Kawaguchi T, Kotaka M, Manaka D, Hasegawa J, Takagane A, Munemoto Y, Kato T, Eto T, Touyama T, Matsui T, Shinozaki K, Matsumoto S, Mizushima T, Mori M, Sakamoto J, Ohtsu A , Yoshino T, Saji S, Matsuda F.
Large-scale prospective genome-wide association study of oxaliplatin in stage II/III colon cancer and neuropathy.
Ann Oncol.
2021 Nov;32(11):1434-1441.
doi: 10.
1016/ j.
annonc.
2021.
08.
1745.
Epub 2021 Aug 12.
PMID: 34391895.

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