In addition to thrombolysis and lowering blood pressure to treat dementia, can ta also make oral ulcer patients eat it?

Oral mucositis is also one of the adverse reactions related to upper body radiotherapy or radiotherapy and chemotherapy

Oral mucositis is also one of the adverse reactions related to upper body radiotherapy or radiotherapy and chemotherapy

In 1987, Sumi et al.

In 1987, Sumi et al.

The purpose of this study is to study the changes in mouse body weight, information and epithelial cell regeneration to determine the role of crude nattokinase extract NCE in the treatment of oral mucositis

The supernatant separated from the Bacillus subtilis culture medium (BSCM) is the crude nattokinase extract (NCE), and the particles are named Bacillus subtilis mass (BSM)

The supernatant separated from the Bacillus subtilis culture medium (BSCM) is the crude nattokinase extract (NCE), and the particles are named Bacillus subtilis mass (BSM)

1,

The results showed that the fibrotic activity of NCE was about 8,069 U/ml, BSCM was about 10,800 U/ml, and the BSM activity was only 80 U/ml (Figure 1)

The results showed that the fibrotic activity of NCE was about 8,069 U/ml, BSCM was about 10,800 U/ml, and the BSM activity was only 80 U/ml (Figure 1)

2.

2.

A mouse oral mucositis model was established, and the relative body weight of the mice after administration was used to evaluate the healing degree of oral mucositis

3.

NCE accelerates the healing of oral mucositis

On the third day after treatment, the area of ​​oral mucositis in the NCE group was reduced, and the exudate was less than the other three groups

On the third day after treatment, the area of ​​oral mucositis in the NCE group was reduced, and the exudate was less than the other three groups

4.

NCE can promote mucosal epithelial regeneration in oral mucositis

H&E staining results showed that the epithelial cells of mice in each group were destroyed 72 h after acetic acid treatment, accompanied by severe inflammatory cell infiltration
.
After 3 days of treatment, compared with the other three groups, the NCE group had smaller lesions and reduced inflammatory cell infiltration
.
On the 6th day after treatment, the epithelium in the NCE group was completely recovered without inflammatory cell infiltration, and the epithelium in the other three groups was not repaired and there was still inflammatory cell infiltration (Figure 4a)
.
As shown in Figure 4b, the difference in histopathological scores between the NCE group and the PBS group was statistically significant (p < 0.
01)
.

H&E staining results showed that the epithelial cells of mice in each group were destroyed 72 h after acetic acid treatment, accompanied by severe inflammatory cell infiltration
.
After 3 days of treatment, compared with the other three groups, the NCE group had smaller lesions and reduced inflammatory cell infiltration
.
On the 6th day after treatment, the epithelium in the NCE group was completely recovered without inflammatory cell infiltration, and the epithelium in the other three groups was not repaired and there was still inflammatory cell infiltration (Figure 4a)
.
As shown in Figure 4b, the difference in histopathological scores between the NCE group and the PBS group was statistically significant (p < 0.
01)
.
<

In summary, this study confirmed the role of NCE in the healing of oral mucositis
.
The results show that in the murine oral mucositis model, NCE is closely related to weight change, information control and epithelial regeneration
.
The clinical manifestations of oral mucositis are diffuse mucosal erythema and ulcers, accompanied by oropharyngeal pain, which interferes with eating and swallowing
.
Especially eating cold, hot, sour and irritating foods often causes severe pain, which seriously affects the quality of life
.
The current treatment of oral mucositis includes oral zinc sulfate, chlorhexidine, honey and laser treatment, but these measures will bring additional pain to the patient
.
NCE has significant potential in reducing pain and promoting the healing of oral mucositis, and it has high safety
.
This study is also the first report that NCE extracted from the supernatant of Bacillus subtilis can promote the healing of oral mucositis and may become an effective alternative to existing treatments in the future
.

In summary, this study confirmed the role of NCE in the healing of oral mucositis
.
The results show that in the murine oral mucositis model, NCE is closely related to weight change, information control and epithelial regeneration
.
The clinical manifestations of oral mucositis are diffuse mucosal erythema and ulcers, accompanied by oropharyngeal pain, which interferes with eating and swallowing
.
Especially eating cold, hot, sour and irritating foods often causes severe pain, which seriously affects the quality of life
.
The current treatment of oral mucositis includes oral zinc sulfate, chlorhexidine, honey and laser treatment, but these measures will bring additional pain to the patient
.
NCE has significant potential in reducing pain and promoting the healing of oral mucositis, and it has high safety
.
This study is also the first report that NCE extracted from the supernatant of Bacillus subtilis can promote the healing of oral mucositis and may become an effective alternative to existing treatments in the future
.

Original source:

Original source:

Zhang et al.
Nattokinase crude extract enhances oral mucositis healing.
BMC Oral Health (2021) 21:555
https://doi.
org/10.
1186/s12903-021-01914-4

.
Zhang et Al Nattokinase Oral mucositis Healing crude Extract enhances the BMC Oral Health (2021) 21 is:.
555
https://doi.
org/10.
1186/s12903-021-01914-4


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