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Front Oncol: The efficacy and safety of PD1 inhibitor penpulimab combined with Anlotinib in the first-line treatment of Chinese patients with unresectable hepatocellular carcinoma (uHCC)

 Last Update: 2021-12-04
 Source: Internet
 Author: User

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Primary liver cancer is the fourth leading cause of cancer death in the world, with a 5- year survival rate of only 12-20%

AK-105-203 (ClinicalTrials.

2019 Nian 1 Yue 24- to 12 Yue 13 the date, in China 8 centers screened the 41 patients finally included 31 patients, 29 were enrolled in the efficacy analysis queue

The median progression-free survival (PFS) estimated by the researchers was 8.

96.

In summary, studies have shown that Penpulimab + Anlotinib has good anti-tumor activity and safety as a first-line treatment for uHCC patients

Original source:

Han C, Ye S, Hu C, Shen L, Qin Q, Bai Y, Yang S, Bai C, Zang A, Jiao S and Bai L (2021) Clinical Activity and Safety of Penpulimab (Anti-PD-1) With Anlotinib as First-Line Therapy for Unresectable Hepatocellular Carcinoma: An Open-Label, Multicenter, Phase Ib/II Trial (AK105-203).

Han C, Ye S, Hu C, Shen L, Qin Q, Bai Y, Yang S, Bai C, Zang A, Jiao S and Bai L (2021) Clinical Activity and Safety of Penpulimab (Anti-PD-1) With Anlotinib as First-Line Therapy for unresectable Hepatocellular Carcinoma:.
.
An Open-Label, Multicenter, Phase Ib / II Trial (AK105-203) Front Oncol 11:.
684867 doi:.
10.
3389 / fonc.
2021.
684867

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