J Clin Oncol: The treatment compliance of patients with early-onset colorectal cancer is better than that of late-onset patients, but the prognosis is worse!

The incidence of early-onset (EO) colorectal cancer (CRC, age <50 years) continues to increase

Colorectal cancer

The study analyzed individual patient data from six trials in the International Adjuvant Chemotherapy Duration Evaluation Database, and compared the characteristics, treatment compliance and adverse events of patients with stage II or stage III early-onset colorectal cancer and late-onset colorectal cancer.

Disease-free survival rate of patients with early-onset and late-onset colorectal cancer in different stages

Disease-free survival rate of patients with early-onset and late-onset colorectal cancer in different stages

Of the 16349 patients, 1564 (9.

Cancer-specific mortality in patients with early-onset and late-onset colorectal cancer in different stages

Cancer-specific mortality in patients with early-onset and late-onset colorectal cancer in different stages

Gastrointestinal toxicity is more common in patients with early-onset colorectal cancer; hematological toxicity is more common in patients with late-onset colorectal cancer

Compared with patients with late-onset colorectal cancer, the cancer-specific prognosis of patients with early-onset colorectal cancer is significantly worse, especially for high-risk stage III colorectal cancer patients: 3-year recurrence-free survival rate is lower and late-onset colorectal cancer Compared with patients, the cancer-specific prognosis of patients with early-onset colorectal cancer is significantly worse, especially for high-risk stage III colorectal cancer patients: 3-year recurrence-free survival rate is lower, 5-year cancer-specific mortality rate is higher, 5-year cancer Higher specific mortality

In summary, being young is a poor prognostic factor for high-risk stage III colorectal cancer, and is associated with a particularly high recurrence rate; even if patients have better treatment compliance and can tolerate higher-intensity treatments

Being young is a poor prognostic factor for high-risk stage III colorectal cancer, and is associated with a particularly high recurrence rate; even if patients have better treatment compliance and can tolerate higher-intensity treatment, young people are high-risk stage III colorectal cancer Poor prognostic factors are associated with a particularly high recurrence rate; even if patients have better treatment compliance and can tolerate higher-intensity treatments

Original source:

Original source:

Elisa Fontana, et al.

Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin

in this message