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J Immunother Cancer: Efficacy and safety of Nivolumab combined with ipilimumab in the treatment of rare advanced gynecological tumors: from the CA209-538 clinical study
Time of Update: 2021-12-03
In summary, studies have shown that the combined treatment of Ipilimumab and nivolumab has significant clinical activity and good safety in advanced rare gynecological malignancies, and it is worthy of further study .
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Prostate: What is the prognostic value of 11C-choline PET/CT in patients with metastatic castration-resistant prostate cancer?
Time of Update: 2021-12-03
174650 31260 Recently, American researchers published an article in "Prostate", evaluating 11C-choline positron emission tomography/computed tomography (PET/CT) in metastatic castration-resistant prostate cancer undergoing docetaxel chemotherapy ( mCRPC) prognostic utility in patients .
Prognostic role of 11C-choline PET/CT scan in patients with metastatic castrate resistant prostate cancer undergoing primary docetaxel chemotherapy.
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Radiology: Do you know this scoring system in predicting the progression of chronic hepatitis B HCC?
Time of Update: 2021-12-03
And the Chinese University HCC prediction score (hereinafter referred to as CU-HCC) model constructed by age, albumin level, bilirubin level, HBV DNA level and liver cirrhosis predicts the development of HCC during the 3-year and 5-year follow-up , showing that the subjects The area under the operating characteristic curve (AUC) is about 0.
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BMJ: Effects of postoperative exercise on upper limb function in breast cancer patients
Time of Update: 2021-12-03
Recently, researchers investigated the impact of exercise on the quality of life and exercise capacity of people at high risk of upper limb disability after breast cancer surgery .
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Cell Chemical Biology: "Miracle Drug" Rapamycin, "One Arrow and Three Eagles" Anti-tumor
Time of Update: 2021-12-03
Cell Chemical BiologyThe study found that in addition to inhibiting the known target of mTOR, rapamycin can also directly target the "un-druggable" STAT3 and affect another "un-druggable" c-Myc.
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The official draft of "Guiding Principles for Clinical Research and Development of Anti-tumor Drugs Oriented by Clinical Value" is released
Time of Update: 2021-12-03
Announcement of the Center for Drug Evaluation of the State Food and Drug Administration on Issuing the Guiding Principles for Clinical Research and Development of Anti-tumor Drugs Oriented by Clinical Value (No.
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Int J Urol: Investigation of predictors of contralateral upper urinary tract recurrence after radical resection of upper urothelial carcinoma
Time of Update: 2021-12-03
According to published literature, the postoperative recurrence rate of these two operations is very high, mainly including bladder recurrence, Local recurrence and CUTRRecently, an article was published in the journal Int J Urol, which explored the key predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer .
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J Ebdovasc Ther: Results of a multicenter study of CH-EVAR in the treatment of asymptomatic dPAA patients
Time of Update: 2021-12-03
evaluated the efficacy of elective CH-EVAR in the treatment of asymptomatic dPAA patients, and the results were published in J Endovasc Ther .
Kaplan-Meier curves of the patency rates in the first and second phasesSummarizeSummarizeFor the treatment of dPAA, elective CH-EVAR surgery is long-lasting and effective .
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Thorac Cancer: Retrospective analysis of the efficacy of docetaxel combined with ramucirumab in second-line treatment of advanced NSCLC patients with advanced chemotherapy combined with immunotherapy
Time of Update: 2021-12-03
This retrospective study showed that in the second-line treatment of advanced NSCLC patients, patients with longer progression-free survival who received chemotherapy combined with immunotherapy are expected to benefit from docetaxel plus ramucirumab treatment .
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J Immunother Cancer: Efficacy and safety of infliximab ((infliximab) and vedolizumab (vedolizumab)) in the treatment of immune-mediated diarrhea and colitis (IMDC)
Time of Update: 2021-12-03
immune Journal for ImmunoTherapy of cancer magazine published a related study result, The study is a two-center retrospective observational cohort study that collected and analyzed IMDC patients treated with SIT from 2016 to 2020 after the progress of steroid therapy .
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ECLIPSE study: the efficacy of cryoablation in the treatment of metastatic lung tumors
Time of Update: 2021-12-03
The ECLIPSE study published by the Journal of Thoracic Oncology evaluated the feasibility and effectiveness of CA for local tumor control in patients with metastatic lung disease during a 5-year follow-up .
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Science Sub-Journal: First discovery that insomnia is a potential risk factor for fatal cerebral aneurysm rupture
Time of Update: 2021-12-03
A recent study in the Journal of the American Heart Association entitled "Modifiable Risk Factors for Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study" shows that insomnia may be a potential risk of fatal cerebral aneurysm rupture and bleeding Factors .
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Medicine & Science in Sports & Exercise: Large-scale studies have shown that exercise can indeed prevent cancer, but it requires more than 5 hours of exercise per week
Time of Update: 2021-12-03
The research team classified and evaluated the number of cancer cases caused by lack of exercise based on the location of the cancer (breast cancer, endometrial cancer, colon cancer, stomach cancer, kidney cancer, esophageal cancer and bladder cancer) .
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European Radiology: Seeing is not necessarily true: CT images of patients with severe emphysema may underestimate the true size of the tumor!
Time of Update: 2021-12-03
Pathological specimens tumor size measured with two independent radiologists in the axial position compares the measured diameter of the tumor on the CT images and multi-planar reconstruction (the MPR) CT images; also subgroup analysis based on tumor size .
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Clin Cancer Res: Application of OX40 agonist Ivuxolimab in patients with locally advanced or metastatic cancer
Time of Update: 2021-12-03
A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers .
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European Radiology: Multi-parameter MRI to evaluate the depth of tumor invasion of oral tongue squamous cell carcinoma
Time of Update: 2021-12-03
consensusRecently, published in the E uropean a journal Radiology study to evaluate and compare various MRI sequences DOI accuracy in terms of estimated OTSCC to define the optimal sequence DOI clinical evaluation , at the same time to determine the optimal cut -off value , based on MRI The T staging standard established the clinically applicable T staging of OTSCC .
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J Urol: Does the time interval between biopsy and radical prostatectomy affect the outcome of treatment?
Time of Update: 2021-12-03
Among the moderate and high-risk male PC patients, there was no statistically significant increase in the adverse long-term results, including the risk of CRPC, metastasis, and death in men who had been treated for 1 year after the PC diagnosis .
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Radiology: Breast MRI during neoadjuvant chemotherapy must pay attention to this sign!
Time of Update: 2021-12-03
In addition, it can also be vascularRecently, a study published in the journal Radiology explored the relationship between the lack of BPE inhibition and NAC treatment response in HR-positive and HR-negative cohorts, providing a reference for accurate disease identification and further evaluation of treatment effects .
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Nature: New CAR-T therapy is expected to target various types of cancer
Time of Update: 2021-12-03
The study used large data sets and advanced algorithms to identify that the neuroblastoma immune peptide group is rich in protein peptides that are essential for tumorigenesis, and focuses on human leukocyte antigen ( HLA ) -A*24:02 The unmutated peptide found on QYNPIRTTF , which is derived from neuroblastoma-dependent genes and the core transcription regulator PHOX2B , and can be carried by the " peptide-centric " chimeric antigen receptor ( PC-CAR ) Targeted therapy .
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European Radiolog: Have you seen primary renal sarcoma?
Time of Update: 2021-12-03
The random forest algorithm trained based on standardized imaging features and patient demographics shows that the use of cross-validation to distinguish renal sarcoma from non-sarcoma renal tumors has good diagnostic accuracy .
