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J Urol: Does the time interval between biopsy and radical prostatectomy affect the outcome of treatment?

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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Prostate cancer (PC) has an inert process, and it is very important to determine the treatment schedule required for good long-term treatment results
.

For men with low-risk diseases, the safety of delayed treatment has been widely accepted

Prostate cancer (PC) has an inert process.

There are limited data on the impact of delayed treatment on the long-term outcome of patients with intermediate/high-risk prostate cancer (PC)
.

Recently, researchers from the United States published an article in "J Urol" magazine, investigating the effect of the time interval between biopsy and radical prostatectomy on the outcome of treatment

Researchers from the United States published an article in the journal "J Urol", investigating the impact of the time interval between biopsy and radical prostatectomy on the treatment outcome .

The researchers included 3962 middle/high-risk male patients treated with radical prostatectomy (RP) in the SEARCH cohort from 1988 to 2018
.

The Cox proportional hazards model assessed the association between the time from biopsy to RP (up to 1 year) and the time to castration-resistant PC (CRPC), metastasis, and all-cause death

Of the 3962 men, 167 developed CRPC, 248 had metastases, and 884 died after a median follow-up of 85 months
.

The longer delay between biopsy and RP is associated with a reduction in the risk of CRPC (adjusted HR=0.

The risk ratio of delay time to long-term clinical outcome

In summary, among the moderate and high-risk male PC patients , the adverse long-term outcomes, including the risks of CRPC, metastasis, and death, were not statistically significant among men who had been treated with RP for 1 year after the diagnosis of PC.

Among the moderate and high-risk male PC patients, there was no statistically significant increase in the adverse long-term results, including the risk of CRPC, metastasis, and death in men who had been treated for 1 year after the PC diagnosis .

Original source:

Maggie C Lee, Tyler R Erickson, Shannon Stock et al.

Association Between Delay to Radical Prostatectomy and Clinically Meaningful Outcomes Among Patients with Intermediate- and High-Risk Localized Prostate Cancer

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