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Int J Urol: Investigation of predictors of contralateral upper urinary tract recurrence after radical resection of upper urothelial carcinoma

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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Urethral cancer is a malignant tumor disease originating from the urethral epithelium, which may involve the lower urinary tract (bladder, prostate and urethra) and upper urinary tract (renal calyces, renal pelvis and ureter)
.
UTUC accounts for approximately 5% of all urothelial cancers

According to published literature, the postoperative recurrence rate of these two operations is very high, mainly including bladder recurrence, local recurrence and CUTR.

Recently, an article was published in the journal Int J Urol, which explored the key predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer
.

The key predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer were explored The key predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer

Between January 2001 and December 2015, researchers enrolled 548 patients with upper urothelial carcinoma who underwent radical nephrectomy at a single institution
.
They investigated some clinicopathological features and results

Among the 548 patients, the median age was 68 years (range 24-93 years), the median follow-up time after RNU was 41 months (range 8-191 months), and there were 237 male patients (43.
2%)
.
Among them, 328 patients (59.

9%) were older than 65 years old, and 389 patients (71%) never smoked

The median time interval between RNU and CUTR was 15.
4 months (range 3.
4-52.
4 months)
.
The overall survival rate and UTUC-specific survival rate are not affected by CUTR

Univariate and Multivariate Analysis for Predicting Clinicopathological Parameters of CUTR

In summary, preoperative estimated glomerular filtration rate <30 and tumor multifocality are important predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer

Preoperative estimated glomerular filtration rate <30 and tumor multifocality are important predictors of contralateral upper urinary tract recurrence after radical nephrectomy for upper urinary tract cancer.

Original source:

Chuan-Shu Chen, Jian-Ri Li, Cheng-Kuang Yang et al.

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