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JAMA Oncology: All-trans retinoic acid combined with arsenic trioxide has a significant effect on childhood leukemia

 Last Update: 2021-12-04
 Source: Internet
 Author: User

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A phase III clinical trial conducted by the Childhood Oncology Group showed that a combination of drugs is very effective for children with standard and high-risk acute promyelocytic leukemia (also known as APL)

child

Acute promyelocytic leukemia is a subtype of acute myeloid leukemia

APL is an acute leukemia, which means it develops rapidly and requires immediate treatment

diagnosis

The results of the trial were published in JAMA Oncology on November 11.

JAMA

In the trial, 154 children between the ages of 1 and 22 with a new diagnosis of standard or high-risk APL received oral all-trans retinoic acid and intravenous arsenic trioxide for at least 28 days

The two-year overall survival rates for children with standard and high-risk APL are 99% and 100%, respectively, and the event-free survival rates are 98% and 96%, respectively

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