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Eur Radiol: The magnetic resonance T1w/T2w ratio of the foot in the brain may be a sensitive biological indicator of multi-system atrophy!
Time of Update: 2021-01-16
Objective: This study used myelin-sensitive MRI formants and standardized T1 weighted/T2 weighted (sT1w/T2w) ratios to detect early changes in the mid-brain foot (MCP) in patients with multisyscopic atrophy cerebrocephalus (MSA-C).
in the early MSA-C group, the MCP sT1w/T2w ratio was associated with the ICARS score.
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Neurology: Transient hypotension is linked to falls and fainting in Parkinson's patients
Time of Update: 2021-01-16
addition to the classic OH (cOH), there is also transient OH (tOH), which shows a significant drop in blood pressure after OH standing, but recovers within 30 seconds.
first screened people who had systolic pressure drop ≥20mmhg or 20mmhg or 20mmhg≥) after standing, and returned to normal within 1 minute, i.e. tOH.
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Stroke: In stroke patients treated with anticoagulants, small hemorrhages in the brain can significantly increase cardiovascular disease
Time of Update: 2021-01-16
Kang-Ho Choi of All-South University Hospital in South Korea and others studied the presence, burden and location of micro-bleeding in patients with acute ishemia stroke and atrial fibrillation treated with OAC on the risk of major adverse cerebrovascular and cardiovascular events.
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Journal of Science: Relationship between natural A-beta antibodies and alzheimer's brain amyloid and cognitive function
Time of Update: 2021-01-16
Alzheimer's disease (AD), commonly known as Alzheimer's disease, is a de-detox. early stages, AD is characterized by aggregation and memory loss of amyloid β (A beta) and tau proteins in the brain.
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BRAIN: 18F-FLT PET Imaging of Meningoma: Predictive Indicators of Tumor Progress
Time of Update: 2021-01-16
study shows that 18F-FLT PET is a promising alternative to imaging biomarkers that can be used to predict the progression of subsequent tumors of un treated and asymptomatic residual meningomas.
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JAHA: Five-year risk of acute myocardial infarction after acute ischemic stroke
Time of Update: 2021-01-16
estimates of cumulative morbidity and annual risk over a five-year basis based on predefined demographic subgroups, stroke-type, coronary heart disease (CHD) disease histories, and known CHD risk factors.
, the AMI rate of AIS patients is relatively low and the highest in the first year after stroke.
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Sci Adv: A new nanoparticle delivery platform that breaks through the blood-brain barrier and brings hope to a wide range of neurological diseases
Time of Update: 2021-01-16
research team developed a nanoparticle delivery platform that breaks through the blood-brain barrier and successfully delivers therapeutic drugs to the brain, which in mouse models of traumatic brain injury (TBI) is three times more efficient than previous conventional delivery methods and has significant therapeutic effects, opening up new possibilities for treating a variety of neurological diseases.
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Cell Rep puzzle: Why does "shake" make you sleep better?
Time of Update: 2021-01-16
to understand this mystery, the researchers used fruit flies to build a model system to study vibration-induced sleep mechanisms.
In addition, fruit flies improve their sleep capacity when they are exposed to vibration multiple times, suggesting that habitualization is a simple, non-correlated way of learning that regulates sleep through monotonous stimuli.
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Acta Neuropathologica: A multifaith pathology model of heterogeneity at the age of onset of familial Alzheimer's disease
Time of Update: 2021-01-16
AD has a wide range of clinical characteristics, according to AD's amyloid hypothesis, the production and aggregation of β-amyloid peptides (A beta) are the initiators and main factors of a series of events, including oxidative stress, synaptic dysfunction, mitochondrial dysfunction and neurodegenerative changes caused by excessive phosphateization of Tau protein (pTau).
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Lancet Digit Health: Video games are approved as "prescription drugs" that can treat ADHD in children
Time of Update: 2021-01-12
FDA website screenshots This game, or drug, is called EndeavorRx, the first half of the word Endeavor means "endeavour, hard work", and the suffix Rx is a commonly used short form of the word prescription medicine, said to be from the Latin word Recipe.
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Annals of Neurology : NT1 Tau can be used as a specific, early marker of Alzheimer's disease
Time of Update: 2021-01-12
the significance of this study is that plasma NT1 tau was found to be a more specific marker of AD (as opposed to NfL), elevated in the early stages of the disease, and can be used as a first round of screening to identify individuals at risk of AD.
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Neurology: The relationship between cell phone use and headaches
Time of Update: 2021-01-12
cross-sectional study was conducted in India between June 2017 and December 2018 to assess the relationship between smartphone use and the occurrence and/or severity of new headaches.
the main purpose is to determine the association between the use of a smartphone and new headaches or increased severity.
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Neurology: Reliability of secondary progressive multiple sclerosis clinical trials
Time of Update: 2021-01-12
the results found that in both data set, EDSS had the highest improvement rate, the smallest difference between progress and improvement rate over time, followed by T25FW and 9HPT.
Reliability of Outcome Measures in Clinical Trials in Secondary Progressive Multiple Sclerosis.
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Annals of Neurology: Retina thickness predicts cognitive decline in Parkinson's patients
Time of Update: 2021-01-12
patients with iPD had a lower GCIPL and pRNFL thickness in the sub-central nest (RR s 3.49, p s 0.03) at a baseline state, and an increased risk of cognitive decline over a three-year term (RR s 3.28, p s 0.045).
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Fda releases mRNA-1273 data Rongchang Bio...
Time of Update: 2021-01-06
December 16, 2020 / Medical Information List: FDA releases detailed data on Moderna's new crown vaccine; Takeda's innovative glucoticoid formula is eligible for priority review; Rongchang BioADC New Drug Launch Phase 3 Clinical; and BioFFR Inhibitors Approved Clinically ...
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First vaccination has protective effect FDA releases Pfizer/BioNTech new...
Time of Update: 2021-01-06
On December 10, the FDA will hold a meeting of the Vaccines and Biologics Advisory Committee (VRBPAC) to review BNT162b2, a candidate new crown vaccine jointly developed by Pfizer/BioNTech.
Vaccines and Related Biological Products Advisory Committee Meeting, December 10, 2020, FDA Briefing Document, Pfizer-BioNTech COVID-19 Vaccine.
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218 drugs, a batch of hospitals not for sale (with list)
Time of Update: 2021-01-06
how many pharmaceutical companies in the future how many product regulations will be due to drug prices and other factors to actively scrap the bid, this we do not know.
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Ab Cellera submits NASDAQ IPO application to raise $3.57...
Time of Update: 2021-01-06
company's core technology is a high-flung microflow platform that uses miniaturized laboratory methods to screen antibodies from millions of immune cells from any species, including directly from human patients.
year, a number of AI-plus new drug companies have completed different rounds of financing, including multiple financings of more than $100 million.
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Focus on the clinical progression of drug target IDH target drugs and their accompanying diagnostic solutions
Time of Update: 2021-01-06
representative part of the project is listed below: Figure 3 On IDH Clinical Trial Distribution Chart 1 Representative IDH Gene Mutations U.S. Approved IDH Accompanying Diagnostic Kits August 1, 2017, FDA Approves Idhifa (enasidenib, Celgene Corp.) Used to treat adult patients with recurring or incurable acute myeloid leukemia (AML) with specific gene mutations.
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Gospel! New research has shown that perinatal tissue stem cells can significantly promote burn healing
Time of Update: 2021-01-06
Perinatal tissue-filled stem cells to save burn patients in China and the research team selected 82 cases of II.degree burns aged 15 to 65 years old as the subject of the study, divided all patients into two groups, respectively, to receive umbilical cord interstity charge stem cell transplantation and routine burn treatment.
