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It is necessary to look for sensitive, widely used, blood-based screening methods to identify patients with AD in the early stages of symptoms.
David Mengel of Harvard University, among others, recently developed an ultra-sensitive immunoanalytation technique, NT1 tau, to detect tau proteins captured by mid-region antibody BT2 (194-198) and to test with n-end antibody taut12.
the name NT1 is not a trademark, but is used to distinguish between their detection methods and other N-side tau detection methods, not all N-side tau detection methods detect the same tau molecular form.
, the molecular heterogeneity of tau proteins makes the comparison between test results based on different anti-tau protein combinations challenging.
In a previous study, NT1 analysis was better able to distinguish AD and AD-MCI (mild cognitive impairment) from the control group than indoor analysis, which used monoclonal antibodies the same as Quanterix analysis, and effectively distinguished between AD and control groups in two separate coding regions, NT1 tau.
addition, the nerve fiber light chain (NfL) is a particularly rich cytostebrae component of neurons in axons.
NfL levels increased in many neurodegenerative diseases, and several studies have found elevated levels of NfL in simple AD or preclinical AD, serum and plasma.
, the baseline NfL was also higher in patients with AD and non-AD dementia than in the control group.
tested NT1 tau and NfL levels in plasma in THEI, AD dementia, non-AD dementia, and control groups.
showed a significant increase in NT1 tau levels in AD compared to the control group, but not in non-AD.
but NfL increased significantly in both AD and non-AD dementia.
NT1 tau levels were higher in patients who developed AD dementia from MCI.
the significance of this study is that plasma NT1 tau was found to be a more specific marker of AD (as opposed to NfL), elevated in the early stages of the disease, and can be used as a first round of screening to identify individuals at risk of AD.
origins: Mengel, D., Janelidze, S., Glynn, R.J., Liu, W., Hansson, O., and Walsh, D.M. (2020). Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease. Annals of Neurology, 88(5), 878-892.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjE4NjEtMTYxMDMxODczMDYwMyIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IkEiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxN。 iwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoibiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJuIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImEiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoibCIsInN0eWxlcyI6eyJmb250LX。 NpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJzIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IiAiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoibyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJmIiwic3R5bGVzIjp。 7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IiAiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiICIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJOIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImUiLCJz。 dHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoidSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJyIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Im8iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyI。 joibCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJvIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImciLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNiwiY29sb3IiOiIjMWMxZDFlIiwiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoieSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fS。 x7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Iu+。 8miIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2LCJjb2xvciI6IiMxYzFkMWUiLCJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTYsImNvbG9yIjoiIzFjMWQxZSIsImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Ik4iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiVCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiIxIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IiAiLCJzdHlsZXMi。 OnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiVCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJhIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6InUiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5Y+。 vIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuS9nCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLkuLoiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6Zi/ Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuWwlCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLlhbkiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5rW3Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Ium7mCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnl4UiLCJzdHlsZXMiOnsiYmFjay1j。
